Conserved Protein Domain Family
HEXIM
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pfam15313: HEXIM (this model, PSSM-Id:291959 is obsolete and has been replaced by 464638)
Hexamethylene bis-acetamide-inducible protein
HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Links
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Statistics
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PSSM-Id: 291959
Aligned: 32 rows
Threshold Bit Score: 83.157
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003111609  40 PYSPgnSDEETAKDFDKKQKNKRAEKPDRFG--------------MAPPNSTQFLLDDRearadaefeneqrfeaaerrr 105 Caenorhabditis ...
XP_003143400 113 PYRT--LSLKEKIVQEEKEERNAVEKRERLFsrg---------kpMAPYNTTQFLLEDHek------------------r 163 eye worm
XP_006567926 131 PYSKqqLSYQQQLR---------YRSRGRLAktg--------rqpPALYNTTQFLMDDHsdlpdl----------dqkls 183 honey bee
XP_003385262  82 PYSK--MSLEERKQVDEWEEKHVAIREAEINars--------krpVAPFNSTQFLIDDRced---------------qyr 136 Amphimedon quee...
EGI69951     101 PYSKq-LSYQQQL---------RSKYIGRIAkts--------rqpPALYNTTQFLMADHsdlpdl----------eqkls 152 Panamanian leaf...
XP_003378268  96 PYFK--LSLEERQRLELREERRAERIRAQRFahg---------lpVAPYNTTQFLLDDRea------------------r 146 Trichinella spi...
XP_003729518 100 PYTQ--LSWEERQQRDEEESRRASLKRANR---------------PTPYNTTQFLMEDHkv------------------v 144 purple sea urchin
XP_002116554  87 NYQN--LSCQEKAELEEMAAEEATQLYNQRIqsg---------lpVTPFNTTQFIMDDYeka------------------ 137 Trichoplax adha...
XP_001628479   1 mnpeglpskamkrQKKTRRLKKRKRLDKEIFdfsvvpvkrakgrtAAPENTTQFLMDDHek------------------f 62  starlet sea ane...
EHJ77757       1 ------MSWQERRKVDN--TKRNNRFRKIVLtk-----------tQAPFNNNQFLMEIH--------------------- 40  monarch butterfly

XP_003111609 106 V---------R----TM----------------SgsydHMRPAY---------------W-CtiepattttYHDDDD--- 137 Caenorhabditis ...
XP_003143400 164 TmppdvgdslP----GM----------------TahqrQSTAGF---------------SpTher----cgTIGQSG--- 201 eye worm
XP_006567926 184 E---------A----AS----------------SelpaTFQKPSa--------------P-Srtr----dsSFSVDS--- 212 honey bee
XP_003385262 137 R---------P----SR----------------TlsfdSSSGVTgamgkwansssniitP-Spsp----gaSDGTNNkcf 182 Amphimedon quee...
EGI69951     153 E---------A----AS----------------LevpaLFPKPWa--------------P-Srtr----dsSFSVDS--- 181 Panamanian leaf...
XP_003378268 147 E---------S----EPicvdeivdtirhegavNdhhgHTKHVP---------------N-Hhhh----hhSDHMVG--- 190 Trichinella spi...
XP_003729518 145 T---------P----DL----------------Sn---MGAFDE---------------Nh----------DVNLSS--- 164 purple sea urchin
XP_002116554 138 --------------------------------------------------------------------rarSVNDNS--- 146 Trichoplax adha...
XP_001628479  63 E---------PfvlsSP----------------SlspnSSGCEF---------------SsSsvr----gsPVCERD--- 95  starlet sea ane...
EHJ77757      41 ---------------KP----------------EpennFLLYRT---------------PsArtr----dsSFSIDS--- 67  monarch butterfly

XP_003111609 138 -------RH------DVDSGSSSSGE-SEADREMEREFETDYLEVKRERIQSMTKSQLAAELLERDQDT 192 Caenorhabditis remanei
XP_003143400 202 -------SEmggnttDSASYSGGEDD-E-----MERQFDADYDYVNMERISNMTKDEVAREYMHLEKIN 257 eye worm
XP_006567926 213 -------DE------DYFYSSPEDEE-E----FLTKEFSTAYEDLHAERLSTLSKSELIQEYLQLEAKV 263 honey bee
XP_003385262 183 ffyplslGD------DVHYDLSDEDQ-EA---FLEADFNQVYLQLKLNRLEGMSKQDLISQCCNLEDKV 241 Amphimedon queenslandica
EGI69951     182 -------DE------DYFYSSPEDEE-E----FLTKEFSTAYEAVHEERLSTLTKTELIQEYRHLEAKM 232 Panamanian leafcutter ant
XP_003378268 191 -------DE------YSSDSVTTSEG-D--LCMLEREFDYEYETAHAERLEEMSKEQLVQEYIHLEKEL 243 Trichinella spiralis
XP_003729518 165 -------SD------EVLE---NENE-E----YLVRNFTAVYDEVQSERLQQMSKEQLVNEVLELSKKV 212 purple sea urchin
XP_002116554 147 -------DD------LLDEIQRMEDKsENGNYSGEDEFTAHLEEIRFDKYDRMSKGELVRYCYQLDKKI 202 Trichoplax adhaerens
XP_001628479  96 -------LQ------SVTELVGNFDE-L----YFEKDFNDVYDSIHAETLLGLSKQELIYKYMELEKKE 146 starlet sea anemone
EHJ77757      68 -------ED------NYFHSLPEDEE-E----YLTKEFSSVYEDAQCERLSNMSKNELIQEYLLLEAKY 118 monarch butterfly
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