pfam14784: ECIST_C (this model, PSSM-Id:291450 is obsolete and has been replaced by 464316)
C-terminal domain of the ECSIT protein
This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain
Jiyao W et al.(2023). "The conserved domain database in 2023.",