Conserved Protein Domain Family
MscS_porin
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pfam12795: MscS_porin (this model, PSSM-Id:289559 is obsolete and has been replaced by 432790)
Mechanosensitive ion channel porin domain
The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.
Links
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Statistics
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PSSM-Id: 289559
Aligned: 82 rows
Threshold Bit Score: 87.7021
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3J985         50 KMRELEEVQgldEAQKKKLLDLYQLTKERLQTAQGYGDKARVYRQAIEAAPAKIEEINRHLASPgidkaMAALEQIPGET 129  Nitrosococcus...
Q8D2C7         28 dINNIQNNVd---LHKLDAIEYLKSALSFIEDSKLSEKKIKEYRKIIEEFPILSGKIQEEKKTK-----KFNYKNYNSNS 99   Wigglesworthi...
Q6LP65         36 KIGELNQLPn--TPEIVKELDDYLQAQNQIDKTKEFNIRTRQYQLVTETFPQEADKLKQQIAAY-----SSTEFPDFFEW 108  Photobacteriu...
WP_025423648   31 ELQQAQDDKt--aPNQAAMVEALQSALNALAESKASSAKIREYQKAIDDFPALTRQLRDEKDSE-----PDEPDPLSPKL 103  Sodalis sp. HS1
WP_002441588   31 ELEQAKAAKn--QPNQAEVIETLQNALNALEERKTSLERARQYQSVIDDFPALSQTLRQQLARLp----DEETRKAPEGL 104  Shimwellia bl...
ACQ67233       33 fLKKVKSNQk--lPHQKEIIQTLEASIDWLDATEISAKEAKKYQIVINNFESLIKNLQKQIEKE-----DEKPLSIEANL 105  Candidatus Ha...
AFP85455       38 ELQYIQENKn--IQSQEAIIKILQSVLKIIDKGKESIVKISEYHKAIDDFPALTQQLRDEKDIEl-----EKPILFGNKL 110  secondary end...
WP_011706981   29 eellqsvpKt-dTPENQKLRESYQQALQFAREAQRYREQGKAYQQILIDYPKESARLKESLHNYqp-----qPRPALSSL 102  Aeromonas hyd...
AEY00829       28 eallkeipEg-dKPELQKLRDSYNQALQLVREGERYQQQTDRLRQFMDDYPNALKKLEQEKAALkg-----tSTESIPLL 101  Oceanimonas s...
CCM81407       31 ELEQAKAAK----PAQPETVEVLQSALNALEERKSSLERARQYQDVIDNFPKLFQSLRAQLNNL-----SEEPRQVPTGL 101  Klebsiella pn...

Q3J985        130 PLSELEQQLAAEQAGLATLESSLAGLEKQWQEQQSRPRQARDQLTEAKQQQERIEN--DL--KALp-PGEt-sLISE--A 201  Nitrosococcus...
Q8D2C7        100 SSKEINQKLLQANNHLIILANQLNQEQDKAIMISDSISTITGLQEETKKELNDIEN--NIkiLPK--TNS---IEEK--S 170  Wigglesworthi...
Q6LP65        109 GKEELTIEIADQDSALVQLEVTRKNDKNLLLEIEHGIDEFSYQSEALRVKIKKVET--KL--AKTqhDSNdtaALNE--T 182  Photobacteriu...
WP_025423648  104 ASGELNQRLLQANSQLMDLAGQLQQEQDQARAISDSLGLLPQQQTEARRALSDVEQ--QL--QALptPGT---PLEQ--A 174  Sodalis sp. HS1
WP_002441588  105 TIDALNQEILQVSSQLLDKSRAAQQEQERTREIADSLSTLPQKQTETRRQLNELER--RA--GITpsTTT---PLSQ--A 175  Shimwellia bl...
ACQ67233      106 TIQELEQEVIKTNSQLIELTRQIQHEQEEFQQIFDLILKIPAEQSEIRRILSQITQ--QL--QLKsnPLT---PLEQ--A 176  Candidatus Ha...
AFP85455      111 NSNELNQQLLRTNSQLMDVSAQLKKQKDLVRSISNSLSLLPQKQTDARRSLNHVEKhlQL--LGTsmPSS---LLEQ--V 183  secondary end...
WP_011706981  103 KEEALRQAIGLSSNRQLNLRKERQGVMDSLNQLESTGQEYHLRVDELRKQLQQTRT--LL--DRLsfSSEs-dRLQD--A 175  Aeromonas hyd...
AEY00829      102 DGPDLEQALVDAQARRLELRRQREELANTFNLQELSNSGLHNQLDELRQQLRQTQQ--NL--DQLqfTEE---QGRQqnA 174  Oceanimonas s...
CCM81407      102 TADALNQEILQVSSQLLESSRQAQQEQDRAREIADSLNQLPQQQTDARRQLNEVER--RIg-TQT--GNN---ALAQ--A 171  Klebsiella pn...

Q3J985        202 RQLALQARLEVYLNEINMLDQELSSHNVRLQALKAQRDLTAQQVWQTQARVKFLEALIRQRRREEVGQAQEAAARAEWEA 281  Nitrosococcus...
Q8D2C7        171 KFTALKMKKVSKKLKIEELYLEQLSANYRQEIIRLRIDLLKKQYNDIDQDIQIIKNNLYFLRKQETEKALYNVEKIEKQI 250  Wigglesworthi...
Q6LP65        183 LLF--KIEQQFYISQVFMLEAEQLSSGNRRTLTKFKITYANLEIEARQAYRNNLQNMLNRVLRTSADTNIENSDELQENL 260  Photobacteriu...
WP_025423648  175 QATALQAEQAARRLKVEELDLAQLSANNRQELSRLRAELLKKRHDRVDQALQALRNQLNSLRQQEAEQAIEHTEMLAEQv 254  Sodalis sp. HS1
WP_002441588  176 QMFALQADSARLKALVSEQELAQLSASNRQELARLRAELAQKQAGQLDNWLQVLRNQLNTQRQQEAEYALESTELLAENS 255  Shimwellia bl...
ACQ67233      177 QLTLLKAEALAHRAKLNQLELAQLSSNNRQELSRMRIELYQKRHEHKDKLLEILQKNLNDQRYKNAEQALKRTELMAKEC 256  Candidatus Ha...
AFP85455      184 QSTALQAEEVACRLKVEELDLAQLSANNRQELSRLRAEVLKIKHNRVDKEQQLLRHRLNVLHKQEAEQAIEQTEIFVEQi 263  secondary end...
WP_011706981  176 QQLVTRLKEQSLSDRIQMLELEQLSAQQRNDLGKLRLQELNLAITDEDEWQTSLLNQQNQLRRDKTEQALAESERLRKQL 255  Aeromonas hyd...
AEY00829      175 NRILAMVREQSLQRRIQMLELEQLSSGNRDTLNKLRLEILQSRLTDLDQYIDALQNRQNELRRATTEAAIAESERLLDEV 254  Oceanimonas s...
CCM81407      172 QNLALQAESARLKALVDELDLAQLSANNRQELSRARSELAQKQSEQLDAYLQALRNLQNSQRQREAEKALESTELLAENS 251  Klebsiella pn...

Q3J985        282 aGKHPA 287  Nitrosococcus oceani ATCC 19707
Q8D2C7        251 -GSLPN 255  Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis
Q6LP65        261 iDQPPV 266  Photobacterium profundum
WP_025423648  255 -GELPK 259  Sodalis sp. HS1
WP_002441588  256 aNLPPs 261  Shimwellia blattae
ACQ67233      257 aDlpvs 262  Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)
AFP85455      264 -GKLPK 268  secondary endosymbiont of Heteropsylla cubana
WP_011706981  256 tSDMPl 261  Aeromonas hydrophila
AEY00829      255 qTDSPL 260  Oceanimonas sp. GK1
CCM81407      252 -ENLPP 256  Klebsiella pneumoniae subsp. pneumoniae ST258-K26BO
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