3E1R


Conserved Protein Domain Family
EABR
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pfam12180: EABR (this model, PSSM-Id:288991 is obsolete and has been replaced by 463486)
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TSG101 and ALIX binding domain of CEP55
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.
Links
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Statistics
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PSSM-Id: 288991
Aligned: 12 rows
Threshold Bit Score: 45.9431
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3E1R_A        12 EIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFE 45  human
Q99JG7       215 KQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKR 248 house mouse
Q502I3       164 QEQLRDALEKNQHWLVYDQQREAYVQGVLARIKD 197 zebrafish
XP_012729299 234 KQRVAYVQDLNSQWQKYDSSREEYIRALCQRLKE 267 mummichog
XP_007578615 230 KQRVSYVQDLNSQWQKYDSSREEYIRALGQKLKE 263 Amazon molly
XP_012667740 215 KQKVLHVEDLNAKWQRYDTSRDEYVREIHAQLRE 248 small-eared galago
XP_692717    230 KKRVAYVESLNSKWQKYDSSREEYVRGLCQKLKE 263 zebrafish
XP_008434921 165 D-QLKDALEKNQQWLVYDQQREVFVQSVVARTME 197 guppy
XP_011604519 165 D-QLRDALEKNQQWLTYDQQREAYVQSVLTRLME 197 torafugu
ETE66865     165 EIQLKDALEKNQQWIIYDQQREVYVQNLNIRIFD 198 king cobra
XP_005914051 146 QIHLRDALEKNKQWLEYDQQREAYVRAILARMlw 179 Burton's mouthbrooder
XP_006630145 234 KQQVAYVENLNAKWQKYDSSREEFVKGLCQKLKQ 267 spotted gar
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