Conserved Protein Domain Family
RNase_Zc3h12a
?
pfam11977: RNase_Zc3h12a (this model, PSSM-Id:288804 is obsolete and has been replaced by 403256)
Zc3h12a-like Ribonuclease NYN domain
This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.
Links
?
Statistics
?
PSSM-Id: 288804
Aligned: 28 rows
Threshold Bit Score: 103.931
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q01DT3        91 KDEFIVIDGANVAwglaq---klksK---FHT------------K-------SRVPMSSAVLMALNHepWRRRGIRTHAF 145  Ostreococcus t...
Q23342        69 VARTIVIDGANVM-----------------HCgsgypdrrenskS-------SHIPDVMPLLSLIRF--FVVRDFEVFVV 122  Caenorhabditis...
Q4Y011       111 KFRSIIIDGANVCakvinnknsqyyF---DNGe-----------I-------EIIYDCHILYEAYLF--FKKIHVEDIII 167  Plasmodium cha...
Q2CF09        54 KRRWVLVDGSNVM-----------------HW------------K-------GGIPDLATVREVTVR--LGGLGYTPRVI 95   Oceanicola gra...
O26281        15 GYLRVIIDASNVA-----------------HSrk---------nD-------EEKPCIENILSAAEE--LEKLGYEPVII 59   Methanothermob...
XP_001008737 813 SKQLIIIDGMNVA------------I---RYG--------------------QSTFCAKGLQIVVD---FWLNHQAEVLV 854  Tetrahymena th...
EAQ97746      54 HGRSFVLDGTNIA------------L---LHG--------------------PKYPELRYVLAIAVH--LRENGAALSCF 96   Congregibacter...
EDM70348      37 rvvpvvvDGSNVM-----------------HW------------R-------DETPSAETLREVVDH--LKQLGLSPDVV 78   Roseobacter sp...
XP_002633991  50 YLRPICIDGTDVSnklnliirkdmeL---FPM------------D-------KSIFNMRAISMTLWY--FISRGHSATVF 105  Caenorhabditis...
XP_002633081  67 VRRTIVIDGANVM------------HcgsPHT------------DhrkgaiqQNIPDVAALFSLIRY--FVVRDFDVLTV 120  Caenorhabditis...

Q01DT3       146 IPREYvigyvnsvcdggglatvnaECV-EyLGKGMWCNRRLMDEVDKGRLT-----LVSRAGDDGR-----GSRKADDLV 214  Ostreococcus t...
Q23342       123 ISRKY-------------------------AKQDATNFKSAIDRLIENHLCv----VVPSSNLD-------------DSV 160  Caenorhabditis...
Q4Y011       168 VLNPVmk----------------qGNE-YyLRTKKVFNYTYLEKLIKLNVIl----ISNEKYYHSNkgevvKRRTYDDVL 226  Plasmodium cha...
Q2CF09        96 FDANV-------------------GHK-VaGRYLNGRALAGPLGLAGAQVW-----VVPAGTPA-------------DPA 137  Oceanicola gra...
O26281        60 ADASL---------------------------RHEIDDKEQFRKLLEEGKFq----QVPSGTSA-------------DHF 95   Methanothermob...
XP_001008737 855 FLPDFcfsad----------qiekKRQ-K-FQKEKIPEKFKTLPDEVETLIk----LRDQGYATGI-----PNQSYDDSY 913  Tetrahymena th...
EAQ97746      97 FDANT-------------------LYL---FRDHRREQEACFERLISEQPWaacfrVVPGGTQA-------------DPW 141  Congregibacter...
EDM70348      79 FDANA-------------------GYLlA-GRYLRGDELGRMLGLPGAQVRv-----VPRGCPA-------------DPE 120  Roseobacter sp...
XP_002633991 106 LPTNL-------------------RDF-A----QKCSDPHELSLLAKLELIv----FDESNSQHPS-----STV-LLSKT 151  Caenorhabditis...
XP_002633081 121 ISRKY-------------------------AKPGATTFKRAIDELVENNLCi----VIPSSYL-------------DDTV 158  Caenorhabditis...

Q01DT3       215 ILQRAKEADAWICSNDKFRD-HRRErnigfaggkalkEf--ARLRRIDH----NFLIAPGLDDETLQaM-TNASDWSPrc 286  Ostreococcus t...
Q23342       161 ALQFASQINGVVITTDQYRD-HASD------------S---LRFNTIVR----ENRLGIKWENVKCK--------NTR-- 210  Caenorhabditis...
Q4Y011       227 ILELALHKKGCVISNDNYADiWMRTs-----------Nr--KEIQDIIS----YYVIKHSYDKNRGF---SLDLTKKP-- 284  Plasmodium cha...
Q2CF09       138 ILSDARDLGAQVVSNDRFRD-WAEA------------Y---PEIAGPG------FLVRGGYRQGRLR-L-DLDARAPG-- 191  Oceanicola gra...
O26281        96 ILKMAEEEDAKILSNDVFRD-YKDE------------------FQDINS-----RRIPYTFREDKILiG-TSGKPKKV-- 148  Methanothermob...
XP_001008737 914 MIDYARKKNAFIMTNDRYND-HIQN------------YkndPKQMEIVKqwirNNCMSFTFVKDELQ-PdPDFIQKRT-- 977  Tetrahymena th...
EAQ97746     142 ILEQAKKDGADVISNDRFKD-RAKA------------Hr--WIWKRRHG----LEVDRGALQIPSLH-L-SLEPLARP-- 198  Congregibacter...
EDM70348     121 ILDMALDKRARVVSNDRFRD-WAQD------------H---PELTRPG------HVIRGRYDGDKLV-L-DMHDSGLPsi 176  Roseobacter sp...
XP_002633991 152 IATWAEDNDGCIVGSRKKYA-LLGQ------------Ky--TELIDRVT----NSLISPTFTPDHEL---------RV-- 201  Caenorhabditis...
XP_002633081 159 ALEFAAQLNGVVLTSDLYRD-HSNM------------N---NRSRRVVE----KHRLNIGWEI-----I-NDESRNMR-- 210  Caenorhabditis...

Q01DT3       287 GASFFD 292  Ostreococcus tauri
Q23342       211 APNIEN 216  Caenorhabditis elegans
Q4Y011       285 LKYILN 290  Plasmodium chabaudi
Q2CF09       192 ERRRPA 197  Oceanicola granulosus HTCC2516
O26281       149 KNILQK 154  Methanothermobacter thermautotrophicus str. Delta H
XP_001008737 978 KISLEK 983  Tetrahymena thermophila SB210
EAQ97746     199 EDYLRA 204  Congregibacter litoralis KT71
EDM70348     177 GPHRDQ 182  Roseobacter sp. AzwK-3b
XP_002633991 202 GDCVRl 207  Caenorhabditis briggsae
XP_002633081 211 LKNpem 216  Caenorhabditis briggsae
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap