Conserved Protein Domain Family
NMDAR2_C

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pfam10565: NMDAR2_C (this model, PSSM-Id:287527 is obsolete and has been replaced by 463148)
N-methyl D-aspartate receptor 2B3 C-terminus
This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family pfam00060 further upstream as well as the ANF_receptor family pfam01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites.
Statistics
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PSSM-Id: 287527
Aligned: 14 rows
Threshold Bit Score: 718.481
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q12879        839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKK----SPDFNLTGSQSNMLKLLRSAKNISSMSNMNS-- 912  human
XP_006637219  835 HLFYWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHIEEKKK----SSDLDFSSPQANMLKLIKSAKNMTTMSNLNAsr 910  spotted gar
XP_006008257  732 HLFYWKLRFCFPGVCSGKPGFLFSISRGIYSCIHGVHIEEKKK----S-EFDFSN-QTNMLKLLRTAKTMTNMSNLNA-- 803  coelacanth
XP_691754     836 HLFYWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHIDMKKK----SSDLDF-SPQSNMLKLIKSAKQMTNMTNLSGsr 910  zebrafish
XP_002939231  831 HLFYWKLRYCFTGVCTGTPGLLFSISRGIYSCIHGVHIEEKKK----SPDFSFTASQTNMLKLLRASKNIANLSNLNQsq 906  western clawe...
CAG02690      729 HLFYWRLRYCFTGVCSGRPGLLFSISRGIWSCIHGVHIDMKKK-----TDLDF-SPQDKMLKLIKSAKHMTNMSNLGGsh 802  spotted green...
Q01097        840 HLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSvm-nSPTATMNNTHSNILRLLRTAKNMANLSGVNG-- 916  house mouse
XP_005460781  831 HLFYWRLRYCFTGVCSGRPGILFTISRGIWSCIHGVHIDMKKK----APELDF-SPQANMLHLLKSAKSIAL-------- 897  Nile tilapia
XP_003972389  832 HLFYWRLRYCFTGVCSGRPGLLFTISRGIWSCIHGVHIDMKKK----KPELNF-SPQANMLHLLRSAKSVAL-------- 898  torafugu
XP_005810957  929 HWFYWQLRFCFMGVCSGQPGFVFSVSRGIYSCIHGVQIEEKSSsalnSPSATMNNTHSNIMRLLRTAKNMASLSGVNG-- 1006 southern plat...
Q12879        913 -SrmdSPKRAADFIQ-RGSLIMDMVSDKGNLM-YSDNR-SF---QGKESIFGDNMNELQTF--VANRQKDNLNNYV-FQ- 981  human
XP_006637219  911 iN---SPKRATDYMH-GGPMMMDMVVDKGNFL-YADNR-SY---PPKEALYGETGSDLQTF--MGNRHKDNLNNYV-FQ- 977  spotted gar
XP_006008257  804 -SratSPKQTSDYVQ-RGSLLMDMVVDKGGLM-YSDNR-SF---QPKEAHYGDNISEMQTF--ASNHHKDNLNNYV-FQ- 872  coelacanth
XP_691754     911 iN---SPKRGGEFMHsASPMIMDMMAEKGNFI-YTDNR-SY---AQKD-IYGDS-SDLQSY--LTNRHKDHLNNYI-FQ- 976  zebrafish
XP_002939231  907 cN---SPKRTSDYIQ-RNSLLMDMVLDKGNLS-YSDNR-PF---QQKD-VYSENTYDLAML--SGNHPKDNLNNYV-FQ- 972  western clawe...
CAG02690      803 mN---SPKH--EFMHsAGPMIMDMMAEKGNFI-YADNR-SY---APKDMIYGDN-SDLQSY--IANRHKDHLNNYIfQG- 868  spotted green...
Q01097        917 -----SPQSALDFIR-RESSVYDISEHRRSFT-HSDCK-SYnnpPCEENLFSDYISEVERT--FGNLQLKDSNVYQd--- 983  house mouse
XP_005460781  898 -P---SPKRNTVVVQ---PSILDMMSGKGNSL-HTLPQ-KG---PG---LYS-NAVGPQGFlsLSGRHKNLLNNAApFP- 960  Nile tilapia
XP_003972389  899 -S---SPKRNTVLLQ---PSILDVMTGKGNSL-HSLPP-KG---PG---LYS-NAAGPQGFlsLSGRHKNLLNNAApFS- 961  torafugu
XP_005810957 1007 -----SPHSALDFIR-RDSSVYDISEHRRSLAgHSDCKpPY---MPEDNMFSDYISEVERT--FGNLHLKDSNLYQdHYl 1075 southern plat...
Q12879        982 GQHPLT-----LNESNPNTVEVAVSTEs--------------KANSR-P------RQLWKKSVDSIRQDSlsqnpVS--- 1032 human
XP_006637219  978 GQHPLT-----LNESNPNTVEVAVSADa-------------tPGTTK-P------RQLWKKSVETLRQSQ-----GS--- 1024 spotted gar
XP_006008257  873 GQHPLT-----LNETNPNTVEVAVSSEt--------------KVNSK-P------RQLWKKSVETLRQSQ-----GS--- 918  coelacanth
XP_691754     977 GQHPLT-----LNESNPNTVEVAVSADt-------------aQTNAK-P------RALWKKSVDTLRQTPq--------- 1022 zebrafish
XP_002939231  973 GQHPLT-----LNESNPNTVEVAVSAEp--------------KLNSR-P------RQLWKKSVETLRQNQ-----GS--- 1018 western clawe...
CAG02690      869 GHHPLT-----LNDANPNTVEVAVNANs-------------vQTNAKpP------RTLWKKSVDTLRSVPp---gPSp-- 919  spotted green...
Q01097        984 ----HY-----HHHHRPHSIGSTSSIDglyd-------cdnpPFTTQ-P------RSISKKPLDIGLPS-------S--- 1030 house mouse
XP_005460781  961 GQPKAP-----PHQTSPNKPQLSITNDngqtr-----ltgagLTASK-P------RALWKKSVETLKTQPs---vVSp-- 1018 Nile tilapia
XP_003972389  962 MQQKGP-----SLQTSPNKPQLAVTNDngksr-----laglaGDASK-P------RALWKKSVETLKTQPs---vISpgl 1021 torafugu
XP_005810957 1076 HHHGSTpgltgPPPNRPHSLGSASSLEggmfdcdslgggvapIFTTQ-PcsalthRNMSKFDLLSGQTPPs---gQS--- 1148 southern plat...
Q12879       1033 -QRDEATAENRtHSLK----------SPRYLP-----EE--MAHSDISETSNRATCHREPDNS----KNHKTKDNF-KRS 1089 human
XP_006637219 1025 -VQDTLPPDPR-MSMK----------SQRYLP-----EE--AAQSDISDCSSRAQSYKDPDNNq---KHHKPKDNLkKRS 1082 spotted gar
XP_006008257  919 -LKEKVPEEKR-HSVK----------NQRYIP-----EE--VVHSDVSDTSSRATSHKNADNNk---KHHKPKNNFkKRS 976  coelacanth
XP_691754    1023 -gPETLDPr---LSMK----------SQRYLP-----ED--TAHSDISDCSSRATSYKDPDNN----KHLKPKDNLkKRS 1077 zebrafish
XP_002939231 1019 -VNENGTEESk-PSTK----------NQRFLP-----ED--GHFSDVSEASSRATCHIDSENNn---KHHKSKDNLkKRS 1076 western clawe...
CAG02690      920 -MPDMLMPDPR-MSMK----------SQRYLP-----EE--TAHSDISDCSSRAASYKDPENN----KHMKPKDNLkKRT 976  spotted green...
Q01097       1031 -KHSQLSDLYGkFSFK----------SDRYSGh----DD--LIRSDVSDISTHTVTYGNIEGNaakrRKQQYKDSLkKRP 1093 house mouse
XP_005460781 1019 gHSPAPASGPGpPQMK----------SQRYLP-----ED--PQHSDLSECSSRPPSHKDSDSMaa-rGGFKPINQLrKRG 1080 Nile tilapia
XP_003972389 1022 gPSSTPTSGPGpPPMK----------SQRYLP-----EEppPPHSDISECSSRPASHKDSDSMga-rGGFKAINQLrKRG 1085 torafugu
XP_005810957 1149 -FKGGLPDVYGkFSFKggassstyipGPSYCGgrgddDG--NIRSDVSDISTHTVTYGNLEGNa--kKRKQYRDSLkKRP 1223 southern plat...
Q12879       1090 VASKYPKDCSEVERTYLKTK--------SS-----Spr----------------------------------dKIYTIDG 1122 human
XP_006637219 1083 MTSKYPRDCSEVELSYLKSKq-------GG-----S-------------------------------------KIYTIDT 1113 spotted gar
XP_006008257  977 VTSKYPRDCSEVELSYLKSKq-------SS-----Tr-----------------------------------dKIYTIDT 1009 coelacanth
XP_691754    1078 MTSKYPRDCSEVELSYLKNKq-------GG-----Agr----------------------------------eKIYTIDS 1111 zebrafish
XP_002939231 1077 VSSKYPRDCSEVELSYLKLK--------HG-----Snr----------------------------------dKVYTIDG 1109 western clawe...
CAG02690      977 VTSKYPRDCSEVELSYLKSKqvssgtnqAG-----Rgg----------------------------------dKIYTIDS 1017 spotted green...
Q01097       1094 ASAKSRREFDEIELAYRRRPp-------RSpdhkrYfr----------------------------------dKEGLRD- 1131 house mouse
XP_005460781 1081 GG--------------GGGAg-------GG-----Gga----------------------------------sKIYSIDS 1100 Nile tilapia
XP_003972389 1086 ------------------SGa-------GG-----Ggs----------------------------------sKIYSIDS 1101 torafugu
XP_005810957 1224 ASAKSRRELDEIELGYRRKPy-------HI-----ShhhyhsqrsvsppllpserkrgggggnnngnsylfreKESVRD- 1290 southern plat...
Q12879       1123 EKe--PGFHLDPPQFVENV-TL-PENVDFPDPYQDPS----E----NFRKg-DSTLPM---NRNPLHNEEGLSN------ 1180 human
XP_006637219 1114 ERe--LGLHTDQHHFRENR-AL-PEDLEYSEMYQDHN----D----NYRKp-EPVIHL---NSSPLHADDITPN------ 1171 spotted gar
XP_006008257 1010 VTerePSFHIEPHYYREAV-AI-PEDIDFPEIYQDHN----E----NYRKp-EAVVHI---NRTPLHNEDSLPN------ 1069 coelacanth
XP_691754    1112 DRe--LSLHSDPQHYREGR-GLtTDDLDFGEIYSDHN----D----NYRKcdQPIIHL---NSSPMHQSESDLL------ 1171 zebrafish
XP_002939231 1110 DKe--PSFIMDQPKYSENS-P--DQDDDYPDVYQDHN----D----NYRKaeA--LQP---DRTPLHSEGRLPN------ 1165 western clawe...
CAG02690     1018 D----LSLHSDPIHYRESR-GPaADDLEYPEIFSDHS----D----NYRKceQPIIHL---NSSPLHHTDSDLV------ 1075 spotted green...
Q01097       1132 -------FYLDQFRTKENS-PH-WEHVDLTDIYKERS----D----DFKRdsVSGGGPc-tNRSHL-------------- 1179 house mouse
XP_005460781 1101 DQ---ASLQSAPPYQRDSQ-GGsDEHPYPPDLFPPDStyphT----HSHQsdAPILQL---SASLLHHSHSAEAdlhslk 1169 Nile tilapia
XP_003972389 1102 DQ---ASLQSAPPYQRDSQgGG-DDHTYPPDLFPPDS----TyshaHSHQgdTPILQL---NASLLHHSHSAEAdlhslk 1170 torafugu
XP_005810957 1291 -------FYLDQFRPKEGV-PQ-WEHVDLTEGPg-----------------nRDGGVPtctSLVPVEDFLKSKP------ 1338 southern plat...
Q12879       1181 N-D-QYKLYSKHFTLKDKG--S----PHSETSERYRQnsTH------------CRSCL-SNM-PTY-S----GHFT---- 1229 human
XP_006637219 1172 NeN-KYNLYSKHYSLKEKN--V----SPHETNDRYKQ--TH------------CRSCL-SKV-PNY-S----GHFA---- 1219 spotted gar
XP_006008257 1070 NeK-KYNLYSKHYSLKEKN--F----SPFEINDRLKQasTH------------CRSCL-SKM-PNY-T----GHFA---- 1119 coelacanth
XP_691754    1172 ----PDNVYNKHYSLKEKN--I----SPHESNDRFKQ--TH------------CRSCL-SKV-PNYnT----GPYA---- 1217 zebrafish
XP_002939231 1166 N-DiQYKLFSKHYSSKEKN--T----SMSESNDRHRQnsTH------------CRSCL-SNM-PNY-T----GHYT---- 1215 western clawe...
CAG02690     1076 ----PEPTYAKHYNMKEKNlsL----SPHESIDRYKQ--TH------------CRSCL-SKVtASY-Pp--gGSYT---- 1125 spotted green...
Q01097       1180 -----------KHGTGDKH--G----VVGGVP-APWEknLTnvdwedrsggnfCRSCP-SKL-HNY-SstvaGQNS---- 1234 house mouse
XP_005460781 1170 D-K-KYSTYT-HSSVKEKV--GgsfeAPSAGPGTQSVrpGH------------CRSCL-TKL-SGY-S----GLYT---- 1221 Nile tilapia
XP_003972389 1171 D-K-KYSTYT-HSSGKEKA--GgsfeAPSGGSGSQGVrpGH------------CRSCL-TKL-SGY-S----GLYT---- 1222 torafugu
XP_005810957 1339 K-K-SDSK--------------------GGPGSGLAGgeWE------------CRNCRaSGG-KQI-S----IHGGgggy 1378 southern plat...
Q12879       1230 ---------------M---------RSPF-KCDACLRMGNLYDIDEDQM-LQETGNPA-Tg--------EQVYQQDWAQN 1274 human
XP_006637219 1220 ---------------V---------RSPYnRCEACLHMGNLYDISEDQM-LQEAISPL-Nq--------DEMFSHYWPQT 1265 spotted gar
XP_006008257 1120 ---------------M---------RSPYnRCEACLHMGELYDISEDQM-LQEITGAIh---------pEEVYGHQWIQS 1165 coelacanth
XP_691754    1218 ---------------Ga--------RSPYnRCEACLHMGNLYDISEDQM-LQEAMISP-Smh------hDDMFSHYWPQT 1266 zebrafish
XP_002939231 1216 ---------------A---------RSPY-KCDDCLHIGKLYDIDEDQM-LHEAANSMh---------sEDFYEHNWLEN 1260 western clawe...
CAG02690     1126 ---------------SnvsasasatRSPYnRCEACLHTANLYDINEDQL-LTDPLGSP-TlhhqqqqqaDEMFGLYWPQT 1188 spotted green...
Q01097       1235 ---------------G---------RQACiRCEACKKAGNLYDISEDNS-LQELDQPA-ApvavssnasTTKYPQSPTNS 1288 house mouse
XP_005460781 1222 ---------------V---------RSPQaRCDACAHLGNLYDISEDHL-HSHYSHTHpHph------sADMFTHYLPQS 1270 Nile tilapia
XP_003972389 1223 ---------------V---------RSAQaRCDACTHLGNLYDISEDHL-HSHYSH-A-Hph------sGDMFTHYLPQS 1269 torafugu
XP_005810957 1379 ssgmgcgssaggsrpS---------SATCmRCEGCKKTGNLYDISEDNNhPLEQMGGG-Kgg------gGVGCMAAGPQA 1442 southern plat...
Q12879       1275 NALQL------------------------Q-KNK-----LRISRQHSYDN-----I-VDKPREL---------------- 1302 human
XP_006637219 1266 DGPHVq-----------------------K-RNR-----LRLSRQHSFDN-----I-LEKPKDI---------------- 1294 spotted gar
XP_006008257 1166 DVAQLq-----------------------K-RNK-----LKLTRQHSFDN-----I-LEKPKEA---------------- 1194 coelacanth
XP_691754    1267 DGPHV------------------------QrRNR-----LKLSRQHSFDN-----ImLEKPKEI---------------- 1296 zebrafish
XP_002939231 1261 NALHFq-----------------------K-KNK-----LRINRQHSCDN-----I--NKPREQ---------------- 1288 western clawe...
CAG02690     1189 DGPHVq-----------------------K-RNR-----LRLSRQHSFDN-----ImLEKPKDV---------------- 1218 spotted green...
Q01097       1289 KAQ--------------------------K-KNR-----NKLRRQHSYDT-----F-VDLQKEE---------------- 1314 house mouse
XP_005460781 1271 ELGLVgegdglvshfeptpsspsplptssS-AQH-----LQLSRQHSYENvlpdgI-PERQSQA---------------- 1327 Nile tilapia
XP_003972389 1270 ELGLVgegdglvspfetspsspsalptssS-AQH-----LQLSRQHSYEN-----V-IPDGVPE---------------- 1321 torafugu
XP_005810957 1443 QSQAQ------------------------Q-RRKsggfgKQLRRQHSYDT-----F-VDLQKEEsggmgslmgglgggmg 1491 southern plat...
Q12879       1303 -----DLSRPS----RSISLKDRER----L-LEG-NFYGSLFS------------------------------------- 1330 human
XP_006637219 1295 -----DLGRPA----RSVSLKEKDR----F-LED-SPYANMFS------------------------------------- 1322 spotted gar
XP_006008257 1195 -----DLGRPA----RSVSLKEKDR----F-LDE-SPYANMFN------------------------------------- 1222 coelacanth
XP_691754    1297 -----DLNRPA----RSVSLKEKDR----F-LED-SPYANMFN------------------------------------- 1324 zebrafish
XP_002939231 1289 -----DLGRPP----RSVSLKEKER----Y-IQD-SPFAKFLI------------------------------------- 1316 western clawe...
CAG02690     1219 -----DVGRPA----RSVSLKEKDR----FaTSD-SHYANLFN------------------------------------- 1247 spotted green...
Q01097       1315 -----AALAP-----RSVSLKDKGR----F-MDG-SPYAHMFE------------------------------------- 1341 house mouse
XP_005460781 1328 -----HPHM------RGLSLPDRDRerelT-LDE-GAYANVLT------------------------------------- 1357 Nile tilapia
XP_003972389 1322 -----RHSQPQhahmRGLSLPDRDRe--lT-LDE-GAYANVLT------------------------------------- 1355 torafugu
XP_005810957 1492 gpgmgGMLPPP----RSVSLKEKER----Y-MEEnSPFAHIFErhggserererdrdplfyggesqkgsgspfglfrgge 1562 southern plat...
Q12879       1331 ---VPS--SKLSGKKS---------SLFPQGLEDSKRSKSLLPDHTSDNPFL-HS-----HRDD--Q-----RLVIGRCP 1383 human
XP_006637219 1323 ---MKP--DKLFSSKS---------MLFNHNLEESKRSKSLYPDHTSENPFL-HS-----LRED--Q-----RLVHGRSS 1375 spotted gar
XP_006008257 1223 ---IKP--EKLLSSKA---------SIFNHNLEESKRSKSLYLDHSSENPFM-HS-----YHED--Q-----QLVHGRSS 1275 coelacanth
XP_691754    1325 ---IKA--DKLFGSRS---------MLFNRNLEESKRSKSLYPDHPSDNPFM-QS-----IRDD--T-----RLVHGRSS 1377 zebrafish
XP_002939231 1317 ---VPP--EKLLGNNt---------ALFTDSLKESKRSKSLYPDNSSDNPFL-HS-----YQET--Q-----KLSHGRSS 1369 western clawe...
CAG02690     1248 ---MRPysGRLFGTSSk-------sMMFNHNLEESKRSKSLYPTHGSENPFLsYS-----LRDDssS-----RLLHGRSS 1307 spotted green...
Q01097       1342 ---MPAg-ESSFANKSsvtta---ghhhNNPGSGYMLSKSLYPDRVTQNPFI-PT-----FGDD--Q-----CLLHGSKS 1401 house mouse
XP_005460781 1358 ---MRS--DRPLSSRSppspspshhHSLDTPMPLPRRSKSLFPDRPSHNPFL-QSapgtaQRDP--AsqattRMPQRNSA 1429 Nile tilapia
XP_003972389 1356 ---MRS--DRPFSSRSppslspshhHSLDTPMPLPRRSKSLFPDRPSHNPFL-QSapdmtQRDP--AsqavtRLPQRSSA 1427 torafugu
XP_005810957 1563 glhRRSigERDMRDRSlmeggggaaFSL---------SKSLYPDRVNQNPFI-PT-----FGDD--Q-----CLMHGAKQ 1620 southern plat...
Q12879       1384 SDPYK-----HSL---Ps--------QAVND-SYLRSSLRSTASYCSRD---------SRGHNDVYIS--EHVMPYAANK 1435 human
XP_006637219 1376 SDIYK-----QLV---Pv--------KSRND-NNLRSSVKSTASYCSRD---------GRVPNDMYIS--EHAMPYVANK 1427 spotted gar
XP_006008257 1276 SDIYK-----Qs--------------KARND-NNLRSSIKSTASYCSRD---------GRIPNDMYIS--EHVMPYVANK 1324 coelacanth
XP_691754    1378 SDIYK-----QLA---Pi--------KARNE-NNLRSSVKSTTSYCSRD---------GRIPNDMYIS--EHVMPYVANK 1429 zebrafish
XP_002939231 1370 SDIYK-----QSS---Lt--------KARND-NYLRSSIKSTSSYSSRD---------GRVPNDMCAS--EYALPYVTSN 1421 western clawe...
CAG02690     1308 SDIYK-----QLAvasPagiigvppnKTRNDaNNQRSSVKSTTSYCSRD---------GRIANDMYNK--EHVTPYSANK 1371 spotted green...
Q01097       1402 YFFRQ-----PTV---Aga------sKTRPD---FRALVTNKPVVSALHga-----vpGRFQKDICIG--NQSNPCVPNN 1457 house mouse
XP_005460781 1430 HELYK-----QRM---Pvslt--lgnHGNHHfNQHGGQVDQQAFYPPQE---------PPV------V--AYMVPPAASQ 1482 Nile tilapia
XP_003972389 1428 HELYK-----QRM---Plslt--lgnHGSHHsNQHGGHIDHQVFYPQQE---------PPV------V--SYMVPPAASQ 1480 torafugu
XP_005810957 1621 YYLTKqqqqqQQV---Aqn------sRG-----DFRSQLSATSYLPASAtagvmpnvpPRFPKELSLGgmNHHGSMLAVG 1686 southern plat...
Q12879       1436 NNMY-STPR-VLNSC--SNR-RVYKKMPSIESDV 1464 human
XP_006637219 1428 TSAY-SAPR-VLNSC--SNR-RVYKKMPSIESDV 1456 spotted gar
XP_006008257 1325 NSVY-SAPR-VLNSC--SNR-RVYKKMPSIESDV 1353 coelacanth
XP_691754    1430 TSAY-SAPR-VLNSSqfSNR-RVYKKIPSLESDV 1460 zebrafish
XP_002939231 1422 NSVY-SAPR-VVNSC--SNR-RVFKKMPSIESDV 1450 western clawed frog
CAG02690     1372 TSAY-PGQRgVLNSTqfNNR-RVYKKIPSLESDV 1403 spotted green pufferfish
Q01097       1458 KN-----PR-AFNGS--SNG-HVYEKLSSIESDV 1482 house mouse
XP_005460781 1483 PMSYvTAPR-ASSAG--GNRpRLYRRMPSIESDV 1513 Nile tilapia
XP_003972389 1481 PMSYvTAPR-VSSAG--GNRpRLYRRMPSIESDV 1511 torafugu
XP_005810957 1687 P------PR-PFNG---SNG-HVYEKLSSIESDV 1709 southern platyfish
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