Conserved Protein Domain Family
Smac_DIABLO

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pfam09057: Smac_DIABLO (this model, PSSM-Id:286186 is obsolete and has been replaced by 462664)
Second Mitochondria-derived Activator of Caspases
Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.
Statistics
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PSSM-Id: 286186
Aligned: 13 rows
Threshold Bit Score: 307.118
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0IJ31         9 IWSFSYILRE-----------SFP----IVSrrncvs-----------llrasWRKVLSVGVGTSVCAIPVG-QRSEP-T 60  western clawed ...
Q5RBH2         9 SRSVTLLFRYrq-------clCVP----VVAnfkkrcf---------selirpWHKTVTVGFGVTLCAVPIA-QKSEPhS 67  Sumatran orangutan
NP_956640     43 khKTSVLCNSsvhq---rilqRLP----NVA----------------------RSNAVPFSVGTGLCAVPFT-QQVE--N 90  zebrafish
XP_008248773  42 SRSASAWLRRg---------rCVP----AAAggpkrcf---------selvrpWRRAAAVGLGVTLCAVPIA-QESEPhS 98  rabbit
XP_003761096  17 RQSVPVVTRLrrc------rlTDL----VGP----------------------WHKTVAVGFGVSLCAVPIA-QKTEThS 63  Tasmanian devil
XP_007237773  41 RGATTALCSNrksa---rqllRMP----ASS----------------------KTHAAGFSIASTLCSVPFI-QHNE--N 88  Mexican tetra
NP_001232563   8 LRSCCSVLRR-----------SFP----VLAgvrqrgl---------agrsgqWHQA--VGLGVALCAVPVVeQQSSG-S 60  zebra finch
XP_005028262   8 LRSCRSLLRRg-----------FP----VLAaarqqpxxxxpetaglsggsrrWQQALGVGLGAALCAVPVI-EKQNS-S 70  mallard
XP_006628326  32 fRLAGAVLRSei--------vRIP----LLL----------------------RSNFLSLGAGGGLCAVPFS-KQAE--N 74  spotted gar
XP_005989033  20 rraplvaersshrllgavssvSVP----RGT----------------------WSRLV-LGFGATLCAVPIS-QKTESvS 71  coelacanth
XP_003968615  15 RRAACVLLNYrnh------aiQNPgkwaNIL----------------------YTSLASFTIGAGFCAVPFK-QADQ--- 62  torafugu
XP_008118066  17 RQSRPLLAPLrtr------caSGL----RGP----------------------WSKAAALGLGATLAAIPIT-QKHDP-S 62  green anole
AAI50218      19 LSYAASLLSSggscqagrrlfLLP----GIF----------------------RKHWRTLSVTGAICAVPFL-QKPE--N 69  zebrafish
Q0IJ31        61 -LSSESLIKRAVSLVADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYTSLLDKMNSNEESAIWQVIIGARVQMKQL 139 western clawed ...
Q5RBH2        68 -LSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMTSK 146 Sumatran orangutan
NP_956640     91 -LSHESLIRRASCLVTDSANTYLSQTTLALVDALTQYAKALHTLISLQKRYIASIGKLSPVEEDSIWQVIIGQRVEVSDR 169 zebrafish
XP_008248773  99 -LSNDALMKRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRRYASLLGKMNSQEEDEVWQVIIGARVEMTSK 177 rabbit
XP_003761096  64 -LSNEALMRRAVSMVTDSTSTFLSQTTYALIEAITEYTRAVYTLVSLYRKYSSLLGKMNSQEEDAVWQVIIGARVEMSSK 142 Tasmanian devil
XP_007237773  89 -LSHESLIRRASCLLTDSANTYLSQTTLALSDALTLYTTALHTLIALQKRYLNSIGKLTPAEEDSIWQVIIGQRVEVSER 167 Mexican tetra
NP_001232563  61 -LSNDALIRRAVSLVTDSTATLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTTK 139 zebra finch
XP_005028262  71 sLSNDALIKRAVSLVTDSTSTLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTTK 150 mallard
XP_006628326  75 -LSHEALIRRASSLVTDSANTYLSQTTLALVDALAQYAKAVHTLIALQKRYMNSIGKLTPAEEDAIWQVIIGARVEMNDK 153 spotted gar
XP_005989033  72 -LSHGALIKRAVSLVTDSANTYLSQTTLALIDALTEYTKAVHILVSLQQQYANLVGKINPKEEEAIWQVIIGARVEMNEK 150 coelacanth
XP_003968615  63 -LSHDSLIKRAASLVTDSSTTLLSQTTLALIDAITDYSKAVHTLIALQKRYLDSLGKLSPAEEDRIWQVIIGQRAEVNDR 141 torafugu
XP_008118066  63 sLSNEALIRRAASLVTDSTGTLLSQTTYALIDALTEYTTAVYTLVSLYQKYAHLIGKMNSKEEDAVWQVIIGARVEMTEK 142 green anole
AAI50218      70 -LSHEDLVRRASSLVTDSANTFLSQTTLALIDSFTGYIKAVNILVELHKQYEASISKFTPEEENAIWKVILGQRQEVIGR 148 zebrafish
Q0IJ31       140 KEQYLKYESSWQRAVSLSEMAAEAAYQSGADQASVTVRNHIQIVQTQVQQARNQAHIAEVQLAASQTDEI-K-RtITE-- 215 western clawed ...
Q5RBH2       147 HQEYLKLETTWMTAVGLSEMAAEAAYQTGADQAPITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEEL-R-QkTQEeg 224 Sumatran orangutan
NP_956640    170 LEECKRFESNWMNAINICELSAEAAYNSGAEHACTATKTNLQVAQSKVEEIRKISKEAEKKLAETKAEEI-Q-R-MAEya 246 zebrafish
XP_008248773 178 QQEYLKLETTWMTALSLSEMAAEAAYHTGADQASVTARSHVQLVKSQVQEVRQLSQKAEIKLAEAQTQELrQ-K-TQErg 255 rabbit
XP_003761096 143 QEEYLKLETTWMTALSLSEMAAEAAYQSGADQASIMARNHVQLVKTQVQEVRQLSQTAETKLAEAQTEEL-RlR-RPEel 220 Tasmanian devil
XP_007237773 168 LDECTRFESSWVTAVGLCELAVEAAYNSGAEHASMALKNGLQVAQSKVQEMRELRAVAEKSLAEIKAEEI-Q-R-MAEya 244 Mexican tetra
NP_001232563 140 QQEYLRLESSWMTALRLSEMAAEAAYQSGADQASVTARSHIQVVKSQVQEVRLLSQKAETKLAEVQTDEL-----IKAtg 214 zebra finch
XP_005028262 151 QQEYLRLESSWMTALRLSEMAAEAAYQSGADQASVTARSHIQLVKSQVQEVRQLSQKAETKLAEAQTEEL-----IKAqg 225 mallard
XP_006628326 154 LDTCRHFESNWMNAINLSELAAEAAYNAGADQASVTARTNLNMAQTQVEEMKRLSSEAEKQLAEVKVEEI-Q-R-TAAqa 230 spotted gar
XP_005989033 151 QQEYLTFESNWVSAVNLSQVAAEAAYQAGADQASVTVHTCVQLAQKQVADMQQLALNAESKLAEVQVEEI-R-K-TSEre 227 coelacanth
XP_003968615 142 RDQWLRFESTWGSAVKLCETAAEAAYASGAEHASISVRTNMQVAQAQVDEARKLSAEAERKLAEAKVMEV-E-R-MSQrv 218 torafugu
XP_008118066 143 QQEYLKLESRWMTALRLSEMAAEAAYQSGADQASVGTHNHIQLVRTQIQEARQLSQKAESKLAEVQTEEL-M-K-LKEee 219 green anole
AAI50218     149 RKNCTHFESCWMTAVNLSQQAAEAAFNAGADQASVAAQSSLQVAQSQVEQVKQLMLEAEIQLKDSKAEYS-E-R-LQval 225 zebrafish
Q0IJ31       216 DKGNPpsggsprss-lseeeeipEAYLRED 244 western clawed frog
Q5RBH2       225 EERAEse---------------qEAYLRED 239 Sumatran orangutan
NP_956640    247 SSidihd-----------ledvpEAYLRED 265 zebrafish
XP_008248773 256 EGRPEpep-------------eqEAYLRED 272 rabbit
XP_003761096 221 EKGTMpqrpstgg--slmtdheeEAYLRED 248 Tasmanian devil
XP_007237773 245 SSikrqd-----------ledipEAYLRED 263 Mexican tetra
NP_001232563 215 EDSSLpqgvlg--------nadddPYLRED 236 zebra finch
XP_005028262 226 EESSLpqgvig------stdageDPYLRED 249 mallard
XP_006628326 231 AATRAfekagkgd--alseddvpEAYLRED 258 spotted gar
XP_005989033 228 RTASKntgtrkkteaeeteddipEQYLRED 257 coelacanth
XP_003968615 219 TSmenne-----------eeevpDAYLRED 237 torafugu
XP_008118066 220 ALAAArrqas--------veeaeEAYLRED 241 green anole
AAI50218     226 se----------------dedipDAYLRED 239 zebrafish
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