Conserved Protein Domain Family
VIT

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pfam08487: VIT (this model, PSSM-Id:285661 is obsolete and has been replaced by 462492)
Vault protein inter-alpha-trypsin domain
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilization and tumour metastasis as well as in plasma protease inhibition. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (pfam00092) in ITI heavy chains (ITIHs) and their precursors.
Statistics
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PSSM-Id: 285661
Aligned: 348 rows
Threshold Bit Score: 51.7105
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54DU5        111 LKEFNIVSEMTDSCIVSVWTQKYSNLSL--TPVEAVYQIPLAPYATVSDFSVILKDKVLKGKIK-ENEKAKEKYNDA--- 184  Dictyostelium...
XP_005993946   70 VTEFMVKSTIISHYAFTAVSCTMINRMS--EAKEAVFQMQIPAAAFISNFTMIVGGRAHYGEVK-GKEEKQR---SA--- 140  coelacanth
AAI59125       93 vaEFSVQSTIMSRYAFTAVSCTMVNRAA--EAKEGVFQMLIPAAAFVSNFTMIVGGRTYHSEVT-WRKQMAKEGNEL--- 166  western clawe...
XP_011679304  698 igRFDVDSVIVLRYATTTIESEMFNEAS--TPGQAVFKQRVPSNAFITGLALRLNGRTYTSDVT-DPQDTAGLGLGI--- 771  purple sea ur...
XP_011668039  671 LRRYNVESDTTERYARTRVEAEYENVDY--EVHPIEFSQQIPSGAYVSDFFVDIDGERYRGVVQnIRDDDWRNVFAT--- 745  purple sea ur...
XP_011668038  133 tvlFNVMSLIILRYAMTTVEVEMQNEGR--QLGHAVFKHKLPEDAFISNLTITVNGEVYTSEVT-DPQDTAGLGLGN--- 206  purple sea ur...
XP_011679315   64 VTMFHVETRIAVRFASTTVRTNIRNVAT--TAQVMSFDLLLPFKAYISDFDIVVDGVTYTGQAV-D----RCILEENl-- 134  purple sea ur...
CBY23486      451 VKKMVVETNIDNRFGRTIVQSKVQNSHPtpR--DAVFSVFLPDSAFITSYKLYIRNHTYQGEII-DPVHADK-------- 519  Oikopleura di...
XP_007235091   69 IQELSVQTTIISRYAFTAVSCTMFNRHTaaT--QGVFQFQVPQAAYISNFTMIVGGRVFPSQIK-AKEKKVKKD-KEqng 144  Mexican tetra
XP_001331201   64 IQELSIQTTIISSYAFTAVSCSMLNRHSaaA--RGVFQFHIPTAAYISNFTMIVGGRVFPSQVK-AKEKKVKKEGGEnng 140  zebrafish
Q54DU5        185 --IA-----SG----------GQAFLAEKV----E-----G----FFKLQIGNLPPQEDVTVNI 218  Dictyostelium discoideum
XP_005993946  141 --KR-----NGs---------KTPGSAVST----DnggneVe---NFQIAV-SIPGKNRAIFLL 180  coelacanth
AAI59125      167 --GSdkilgNG----------DNG----DN----G-----Me---LFKAS-ASIPGRNKAVFLL 201  western clawed frog
XP_011679304  772 --LE-----IG----------PSGGILSPL----Dl---eNn---LLVVSV-PVDPSNSVTFTL 807  purple sea urchin
XP_011668039  746 --SS-----SG----------QVLAVLARR----D-----Ptk-dAFVMQVPDVRSNGRVTFVL 782  purple sea urchin
XP_011668038  207 --LE-----IG----------RSGGILSPL----G-----DlennLLVIAV-PVEPGERAYFRL 243  purple sea urchin
XP_011679315  135 --RS-----SGvaiatidkyqYTAG--GQY----T-----Rn---VFTVKV-TVPKKKSVKMTV 176  purple sea urchin
CBY23486      520 --KT-----DW----------LSPSTVVPDknddH-----E-----WKVK-VRMDSWDEALFEL 555  Oikopleura dioica
XP_007235091  145 ksKT-----KE----------AAE-----VsdgeM-----E----TFRMA-VTIPGRNRAVFLL 178  Mexican tetra
XP_001331201  141 -------kkKD----------TPE-----QsegeL-----E----VFRME-VTIPGRNRAVFLL 172  zebrafish
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