Conserved Protein Domain Family
DHC_N1
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pfam08385: DHC_N1 (this model, PSSM-Id:285571 is obsolete and has been replaced by 462457)
Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Links
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Statistics
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PSSM-Id: 285571
Aligned: 349 rows
Threshold Bit Score: 127.344
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4CPG2        189 EFIYCLESSIIAWTAQIRTAIDSTPEemtessagkGIRP-GPLDEIAFWKSKAENLANLEEQLYSVKAVKIIVILKKAES 267  Trypanosoma c...
XP_011276466  201 SFLNNIQTIVNEWVKTIQDVTKMEKA---------VLEG-SAADEINFWRSMESSLEAIQEQLDSQGVQLSLEVLKYAKR 270  Wickerhamomyc...
XP_002617671  206 AFLNELTKTVNAWLRQVQSVTLIERN---------NAEVlSIQEEVSFWNSMELALESIKEQVSQPSVRRAIEILNAAKR 276  Clavispora lu...
XP_006687954  139 HLLNEVTNIVNGWTKQIQSITSLSSD---------IANLaSISEEIQFWNSLDISLTSVEQQLSCPQVKNSINLLNKANR 209  Candida tenui...
XP_002548220  203 ALLNELTSIANNWIKQIQSITRLTHE---------PSDGaSITEDIQFWKSMDSVLASLNQQIASSEIKLTREILSKGKR 273  Candida tropi...
EMG45477      198 GFLNELTSIANNWIKQIQGVTRLNHE---------PSDGeSITEDIQFWKSMESALIALNQQIESPEVKLTRDILSKAKR 268  Candida malto...
CCE44726      195 AFINELTAVSNDWIHQISSITKISHS---------TMDSkSIRDEIQFWNTVEIALTSIGKQIKSPEVATTLDVLSKARK 265  Candida parap...
XP_007376164  223 TFLNEVTTIVNNWARQIQGLIRLNHD---------PMDSeSIMEEIQFWKSMEAALLSLNQQVSSFEIKKSVEILNKAKR 293  Spathaspora p...
XP_001386629  240 ILLNELTNIVNNWIKQIQSVTKLDHN---------PWDGdSIIEELSFWRSLEIALTSISQQIAAPEVTTTIDVLNKAKR 310  Scheffersomyc...
EDK40108      212 EILNQVNNTVISWVRQIKNVTTLDHS---------PQSSeSIIDHFHFWKSMDLALKALQHQLKSPEVRYSLQVLNLGKR 282  Meyerozyma gu...

Q4CPG2        268 syyssFFEL-----IN-ELKEASAEARDNYRFLKPIepEFEaiC-PSFp---gHlEFTQLASsgTFKRLFHYLYLLWTQS 337  Trypanosoma c...
XP_011276466  271 -----YHATvsffsDI-EIKEATARAADYNKLMKDI--PLN--E-LLVa-----eDLDKVEE--ALVLILSHL-KKIKLT 331  Wickerhamomyc...
XP_002617671  277 -----FQVTlafqnNI-GIVEKLDETKAYNVLLKDL--PIN--EiIYSkd--nElDLTKMES--GIMSLFNHL-KKWKNS 341  Clavispora lu...
XP_006687954  210 -----FHITlsftnDS-NISSKIIEAKTNLLIWKDF--PLT--E-MTNinpkdSdCLGKFND--SVSGIFNHLK-RLRTI 275  Candida tenui...
XP_002548220  274 -----FHITlgfenDT-GLNEKISETRLYNSFLKEL--PIN--D-LIIit--dDdDLEKFDI--VIASIFSHLKSKLNLL 338  Candida tropi...
EMG45477      269 -----FHITlsfenDI-GLNSKLNEARLYNSFLKEL--PIN--D-LVTit--eDeNFEKFDT--AFTNIFAHLKLKLTIL 333  Candida malto...
CCE44726      266 -----FHITlsfenDI-GLKEMTATASSYRAFFKDI--PLD--ElLVDev----aDYDSFNN--GVYDVLSYVNQKLSSL 329  Candida parap...
XP_007376164  294 -----FHITlgfqnDVsSISDKLTQARLYNSLLKEL--PMN--D-LITisgedEqDFSKFEL--AIVNIFNHLKLKLNSY 361  Spathaspora p...
XP_001386629  311 -----FHVTlsfqnDT-GLQSKINTTKVYNSLFKDF--PIE--D-FISd---sEnVLEKFEI--GLHSIFNHLKSRLKNL 374  Scheffersomyc...
EDK40108      283 -----QRVVtsfenDT-GLEEALARCKTINDVLKDI--PIE--E-VLSisgqdEmAFSKLES--AIQSVFTYL-RRLKNH 348  Meyerozyma gu...

Q4CPG2        338 GFYntPTRLVVLLRFICNDLIGLAAEHVNIEE--FAkn-iEkkDALTRLGE-TLAVCGQFKAAY---F-HYKsylstmar 409  Trypanosoma c...
XP_011276466  332 -SYp-VSRALPFVEAISSDLETKLKPMLSt----IMskdfS--EFTNAITK-LKSLYDTWERHTkefTnIAR-------- 394  Wickerhamomyc...
XP_002617671  342 NTFp-LVRMIELIELLLKEIVSSLTRILLnm--nLMampfA--AFEIEYSGkITSIFHIIDVNVkfmVnIIR-------- 408  Clavispora lu...
XP_006687954  276 SNFp-LSKGLLLTELILKDLLAKFAHLIN--SlnLMnlefE--EFLRIYEGdISNILSTIDLNLkymVnLIR-------- 342  Candida tenui...
XP_002548220  339 p----LERAVKSVEVILNDITSKFQELLG--ThdVMslsqQ--KFEQLYDL-CQKELGIIEANIkyvInLLR-------- 401  Candida tropi...
EMG45477      334 p----LERAVKSVEILLNDVINKFQNLLG--GhdLMslssE--KFDQLYDL-CLKELVMIESNVkyvInLLR-------- 396  Candida malto...
CCE44726      330 p----IPAEIDIIQLLLKDVCRKLQDLISkh--eIMsleyT--SF-RKHQAiVTKSINAINDKLkatTtVLR-------- 392  Candida parap...
XP_007376164  362 p----LTRSVETIEVILNDIISKFQGLLTkk--sIMslsfS--KFSQLYDShINKLFDIIENNIkymInLLR-------- 425  Spathaspora p...
XP_001386629  375 NLYp-LGRSIQTIEVIIVDVTRKFSSILTty--sLTsipmS--EFNEVYNSdIMGIFNLIDQNLkylVnLLR-------- 441  Scheffersomyc...
EDK40108      349 ANFs-TSRSIDLVTGIANEIVSKILHTLRDKD--ILeldiT--AFDDLIQQ-GHSTLNVLEDNIksvVeLLR-------- 414  Meyerozyma gu...

Q4CPG2        410 pwKF-QNtAfffrlDVFL-------------ERCHDLLDVMETAVLFdkmenikvGgTKSQMLTKE------AEEIKAEf 469  Trypanosoma c...
XP_011276466  395 --ELlRKrG-----EKFLvvkins-kttqlkEYTEEIESFRISHNEL--------L-RTLQNd--------iIDETALD- 448  Wickerhamomyc...
XP_002617671  409 --ELmRKrQ-----EKFMivkidqhlltalhERIEHLRDLRRRHQEL----------LHLLSFIDDen--nlTEEITL-- 467  Clavispora lu...
XP_006687954  343 --ELlRKrQ-----EKFFivrvnqemfdqfkHRLEFLKTFRVKHENI--------L-FVIRNFLqdf---dqEPKLMD-- 401  Candida tenui...
XP_002548220  402 --ELlRKrQ-----EKFKiitidqskfeqirERLDHLKSFRINHQNL--------L-SSIDNILPIdekldsLTRLRD-- 463  Candida tropi...
EMG45477      397 --ELlRKrQ-----EKFKiikidqnkfesikERLQHLKEFRSNHSNI--------M-LIVESVLSGseqldsINRLND-- 458  Candida malto...
CCE44726      393 --EIaRKrQ-----EKIKsisidkseldsisFKLKLLTAFRTNHESL--------M-HSVENALSAdersrcVKDLIE-- 454  Candida parap...
XP_007376164  426 --ELlRRrQ-----EKFKiikinqtrfdqikSRLEHLYQFRLNHLDL--------L-QSIENVLSNsdkieaSMKLSD-- 487  Spathaspora p...
XP_001386629  442 --ETlRKrQ-----EKFIiiqinhdgydklrERLDNLKLLRSKHEDL--------L-VLLESILPDnn---sVKRLLE-- 500  Scheffersomyc...
EDK40108      415 --ELsRKrD-----ERFSaikvdqsssailkERLTELSSLRHQHEEL------------LQTFYIAhkesdnIHLLRQ-- 473  Meyerozyma gu...

Q4CPG2        470 dEAYMNFFgvE-YDMLDVDDPR---FDTNYSQFRATIRELERRLGAILVTTIDDAkAISEvfKAVDTFD-G--F------ 536  Trypanosoma c...
XP_011276466  449 -FAYDAVK--Dv-DVF----SNhqsWKDAKKIYEKRIHDIENDIVDTMRNSLDKA-RNSN--EMFQVFEtYrn------- 510  Wickerhamomyc...
XP_002617671  468 --SFSKNI--AaVDAFDFSKQGtsvLQANEQMYLEASSRVSNAISTHVNYKLSYC-DVFS--DFIAYFMkFhen------ 534  Clavispora lu...
XP_006687954  402 --DYNR-L--SvLNLLDFSKHGvflWSSSERHYNNTYSQIQESITSQLNNLFIHC-SNFK--DFVTVAEkYkyLmientf 473  Candida tenui...
XP_002548220  464 --AYNKHI--IpINAVDITHQGklvWSMNEQAYLQVFHELNTLVIKRINTFFADA-TKFI--DVISIYKkFfqskg---- 532  Candida tropi...
EMG45477      459 --AYNKYI--LpINAVDISHQGkliWSMNEQKYQKIFHEVNTLAIKKMNNFFNSA-STFI--DVIAIYKeYfnskn---- 527  Candida malto...
CCE44726      455 --AYNKYI--IpIDVADISHEGksvWSMHEGAYKKVFNTIFTSVVTRINGFFNNA-EQFA--DYLSIYYqFfpNldssnd 527  Candida parap...
XP_007376164  488 --AYNKEI--IsINSVDISYQGslvWKMREESYLEVFNQLNTLIVKRINLFFAKA-STFV--DAMAIYTkFffths---- 556  Spathaspora p...
XP_001386629  501 --AYNKFI--IaSNALDISSQGtiiWQSNERGYLSVSQELSSLMTLQINALFDKC-HTFT--DFLSIIDqFqpLlnstse 573  Scheffersomyc...
EDK40108      474 --SWNHLK--SdTDPFDISKKGsafWDSNVKIYMESYNSALSDLQNLYSARFRDC-QDTS--QMAMILSeY--Sgkgide 544  Meyerozyma gu...

Q4CPG2        537 ------TDHAVVQLEWSKKQKAVLEAFHEDLLAVQEVFYQGEAT----Gsy-----------pN-IPPLAAAVVRCNALL 594  Trypanosoma c...
XP_011276466  511 -----lvTRQRIRGATQEYQSQLLSIVKDEISQLQDAFTK-Kadeky------------ltklHdYPSVAFTLLWAKQVE 572  Wickerhamomyc...
XP_002617671  535 ---gllNSTLIVNFVNEKHKLRLLDIAYADIQSLFKt-----------SyythkesikipksvSlIDSGLSSLIWDMSIK 600  Clavispora lu...
XP_006687954  474 ---------disslMKEDLRLKILDIARTEIFNLIK-FDT-NYNdkleKslnlfv---nsyqtQvEDYTVTRFLRALERR 539  Candida tenui...
XP_002548220  533 -astllLS------ISDEHKLKILSLADKEIMQLVE-MNSs----------------------SgNKSTYEDIKWKIHAT 582  Candida tropi...
EMG45477      528 -stsllLS------MSDEHKLRILSLADREISELTE-INAe---------------------rTdEDLSYDEIEWKIQFN 578  Candida malto...
CCE44726      528 nnasfmTIKD-------NQKLKILDCAMSEIQSLKEDINTCTLNd------------------------YKKILYDKGLI 576  Candida parap...
XP_007376164  557 --ssllVSIND------EYKLKILSIADVEIQKLID-FNSd---------------------rKsSDDIVGQIMWNSSLV 606  Spathaspora p...
XP_001386629  574 sqnkimNLTSD------EYKLRLLTVANSEVEQFIE--SNLNNKtfmsSsisvmndiqamnvyNdEFLLVSEIILNNGLV 645  Scheffersomyc...
EDK40108      545 tlpsllLDADK---------IKILQVAQKEVERLQEIHSKlgls---------------mgrrSqESDIIPTLNMRRGLL 600  Meyerozyma gu...

Q4CPG2        595 DRINESHSRVSelshsllesE-Fg---------KETMELYEKLHNALRdaIRDKYEAWCADVGS----ISV--DK----- 653  Trypanosoma c...
XP_011276466  573 NKLAFLTDRLE---------LiLgkdwslfaegQKIFAEVSALKKKLN--TKPIFDNWLST-Vses------------el 628  Wickerhamomyc...
XP_002617671  601 NKLEFITRTLT---------SiLgenwnkystgADIEQEITSFSQKLR--INAIFEEWVTDVSNairtNMSatR------ 663  Clavispora lu...
XP_006687954  540 NKVSFYDDNLS---------SlVgkdwfkysigGKLKDQMSSFLIKFD--PEEIFKQFLSHLKe---------YTdnnkl 599  Candida tenui...
XP_002548220  583 NKLMFYREFLR---------SfLgdnwknysmgAKVDTTTSRLITSLD--TDAAVQSWIDTEVn---------HKm---p 639  Candida tropi...
EMG45477      579 CKLKFYREYLE---------LfLgynwksyslgAKIEATTNKLISSMD--PNIFIQNWVDAVQa---------QSpa--d 636  Candida malto...
CCE44726      577 SKLNFYRESLS---------KlLgvdwknfsvgSKIDTLTNNLITTLD--PKKAYADWVSNEKam--------------h 631  Candida parap...
XP_007376164  607 SKLSFYRNNLK---------TlLginwnnystgTKIDATTNKIIVSLN--PQLVYNRWIVAIGqkh------------am 663  Spathaspora p...
XP_001386629  646 SKLKFYLKNLE---------KsLgtnwnkysigTKLNVEVSNLLVKLD--TDQLFENWIKGAHni-------------ls 701  Scheffersomyc...
EDK40108      601 ARASFIMDVLRr----------AignwehystgSRLENDMRAFVTIID--PVIIFQNWLTVVKDevlpKIAacAQa---- 664  Meyerozyma gu...

Q4CPG2        654 LKLP--LLEVd-R---------NnN---LKVNFDPALVKTLREVYYLEVMnsfesrdrqkleVPVEVQAVFEKRET--YR 716  Trypanosoma c...
XP_011276466  629 KGN---VFKLikE---------Kdik--lqVTFDEGFIQLFKEVRALSWQgf---------qVPHKVVLSSRHIKK--LY 683  Wickerhamomyc...
XP_002617671  664 ------ILKVeetdvpgtdisstpK---VKVNFNQEMTTYITQAQDLMSLgf---------eIPMNLLVQLEKVCS--AH 723  Clavispora lu...
XP_006687954  600 E-LKgnVFKIsnNsd-------------llLNFNPEFLGLRDNLKFFRAIgf---------kIPVTILLEFQKLNR--LL 654  Candida tenui...
XP_002548220  640 TYNMgtIIKIneS---------SsglfdlsVNFSFNTFDIYSQLNQFHHLgy---------qIPSSVLLEYQKVNQ--LY 699  Candida tropi...
EMG45477      637 TSTLgtVVKVpeN---------Lfd---ltVNFNFKVFDIYNQLNQLQHLsy---------tVPNSVLSGYKRIHQ--LY 693  Candida malto...
CCE44726      632 PRDMgvLLKRpkhgdg---------cyalkLNLDMQKLQSYESGVVLKNLgl---------sTSNTLN----HRKQaaFC 689  Candida parap...
XP_007376164  664 VENLgkIIDIvekssg--------ndfdliVNFNYSLLQIYEQLIQLSNLgl---------dVPSTTLMQYGKIYQ--LH 724  Spathaspora p...
XP_001386629  702 SHEMgpLVRIhhsa------nnevR---IDVNIDTTLLEFCIQATQLRNLgy---------sIPTSISLQLSKIEN--IY 761  Scheffersomyc...
EDK40108      665 -----sIFRTtkies-----ksqrE---VAVALDVSIVTQYNNFREFSGLgf---------eMPLPVHKSFTGLAS--VI 720  Meyerozyma gu...

Q4CPG2        717 SQTMKLDYVSSTYNGFM--------STLRQ--EdEK-------PLIQAELDAFEKIMHQGMNeVCWQDGdGVD 772  Trypanosoma cruzi
XP_011276466  684 PHAVTLAESVEIFPLVL--------SSI------ESlqd--fkILVWSDKERIYHLLEKCLD-ISWETLsrah 739  Wickerhamomyces cife...
XP_002617671  724 PLALSLQEHIDIFDVAV--------TEFLL----HSnagrkfgFMLESQKKRVFEMMPRLMY-VEWSSLcqei 783  Clavispora lusitania...
XP_006687954  655 PMINDLKENILTVKRIF--------DITL-----RKeyfrkfdPLLEIDKLRLSKLLVSMAK-VQWEHLtQAF 713  Candida tenuis ATCC ...
XP_002548220  700 PLATGVYDHIQLLNKIF--------NHDL-----RSkygesygFLISAQIKKVDFALREIRE-VEWMHLlqat 758  Candida tropicalis M...
EMG45477      694 PVTVGINDHVNLLNRLT--------KFEM-----TSaygkdfgFLVTPQIEEIETKITEIQD-IEWVHLlqav 752  Candida maltosa Xu316
CCE44726      690 QIAIEIENVIDMLNRVFdvtngqskTQIF--------------EFISGDVYKLIPLVKQLSR-LEWNHLwqai 747  Candida parapsilosis
XP_007376164  725 PLAIGLRDHVNLLCQLF--------ENMQ-----NSkygqtfgFLLSGQIGKVKESLKPVLS-VEWIHLsqai 783  Spathaspora passalid...
XP_001386629  762 PLVVGLIEQIAVVRNVF--------DYELV----ETeygkkfgKTLSEQQRKVGDCLKVLLD-VNWQHLsrav 821  Scheffersomyces stip...
EDK40108      721 SIATSINESLDFVKGAL--------EEYREslGgNEgsi--tqKLLIKPIQDVLEKCSKLSS-FRWFHFqnfv 782  Meyerozyma guillierm...
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