4M8N


Conserved Protein Domain Family
Plexin_cytopl
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pfam08337: Plexin_cytopl (this model, PSSM-Id:285529 is obsolete and has been replaced by 462434)
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Plexin cytoplasmic RasGAP domain
This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Links
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Statistics
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PSSM-Id: 285529
Aligned: 54 rows
Threshold Bit Score: 362.275
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4M8N_A         47 AIPFLDYKHFASRIFF-----------PEagtltavm-irdigedSEQTTVDE-KCLAFAELIRDKQFLSCFVHALEEQ- 112  zebrafish
O45657       1194 GPELINFPHFVENLLWsdnnltsap---------------------slartlpvTLAQFHALLSFKGFIFTIVEAAESD- 1251 Caenorhabditi...
XP_009861867 1160 riiylppwEYITQVLF-----------NQrsghpv----ldenamVGQGTVKQdALKSLLSVIKNKDVLLVLVRTLEEQ- 1223 vase tunicate
XP_011412156  384 GIPYHSYQSYTQYILF-----------PKeveaatia-sllehsgFSSKNAEK-AMDQFDKLMSNKYFVKSLIGTLEKQ- 449  Pacific oyster
XP_004998121 1444 eahpRPFGEYARRVYF-----------TAldthplp--vrprfpgT-----ND-CIEQFTFFLQQDDFLRAFVGVMEGEg 1504 Salpingoeca r...
EGT44270      956 qPEIVDFSRFMENLLW-----------AEntltv----------pilarTLPM-ALAQFHALLSFKEFIFTIVDVAESR- 1012 Caenorhabditi...
XP_011667763  897 GMPFVSGADYIRNMLFwglkvqpmtndPE----------------LPQESIKQ-AMSEFSKLLNRKEFLMQYIQGLDEA- 958  purple sea ur...
XP_011674296  421 GVPFVNALDYSKNMLFaglavlppttdPE----------------YMNSDLET-AMIMFSRQLSNPDFLTNFIKQLEEQ- 482  purple sea ur...
XP_002113113 1233 SIPYLPFNGYAIKILF-----------PDneeyavh--hflnqreGRRYDDDD-AVLLFADLLYKKKFLKIYLHTIENQ- 1297 Trichoplax ad...
XP_011403706 1263 QLPFHDFPTYATKVFF-----------PAantnhpvlsppkvphgMTHDSMCV-LLDEFRELVFDKKFLVAFIRTLESR- 1329 Amphimedon qu...

4M8N_A        113 KNFSIKDKCTVASLLTLAL--HGDLLYLTEIMEDLLQSLMDQSSn-AN--PKLLLRRTESIVEKLLTNWMSICLYGFL-R 186  zebrafish
O45657       1252 VSISTSEKSMLASLLISVL--LRNFSYCTEVVVDLLRAHIARSVq-NKr-AELLFRNSDSVVEKMFSKWMSICLYSHL-- 1325 Caenorhabditi...
XP_009861867 1224 RKFTVQEKGNMASLLTICL--FDDLPYYTRVMLELLTGLIQKHV--SRn-PKLLLRRSESVVEKMVSHWLSINLYDECiN 1298 vase tunicate
XP_011412156  450 RKITLSDKAQFAANFSVIM--MGKMRDFFEIVNCLLSTLVD-SAn-KKq-HKTLFNRFESISLRLLSHWLSVSLYPYL-K 523  Pacific oyster
XP_004998121 1505 RAFSVRDRCQVASLLMCSA--NGDEAMGTHTLSTLLDQYFTANSr--Rd-PRLMLRRTESVAEKLLTAWLTTGMHDAV-L 1578 Salpingoeca r...
EGT44270     1013 NSISTSEKSMLASLLISVL--IRNFSYCTEIVISLLKTHIAKAVe-NKr-AELLFRNSDSLVEMMISKWWCICLYPSL-K 1087 Caenorhabditi...
XP_011667763  959 KNLKQKDRVNIASLLSTILttEGRFHYLTDVMLTLMAEKIEESD--ENr-LKQLFKSVGSILEKLISNWVALCMYKHL-Q 1034 purple sea ur...
XP_011674296  483 RKPKRRDRVNIASLITALLvtEGKFGYFTETLFKLLEESIEEGA--ESgrARSLFRRTETIVEKLLSNWISICMYQYL-K 559  purple sea ur...
XP_002113113 1298 QDFSMKDRCNVASLLMVAL--QHRMGYVTEILCHLLRELIHKSV--AKnhPKLILRRTECIAEKLLTNWLSFFFYPYL-F 1372 Trichoplax ad...
XP_011403706 1330 PKFNLQDKSTMASLLMVAC--LKDISYSTEVLEALLGNLIRRSLsnTKnhPKLLLRRTESVAEKLLTNWFCVTLYPYM-L 1406 Amphimedon qu...

4M8N_A        187 ESVGQPLFLLVSALTQQISKGPVDSVTEKALYTLSEDWLLCQAQDFEPLKLK--VVFAVgtg-eeISESL--EVIALTCD 261  zebrafish
O45657       1326 TPQMNSYFYLYKALQYQTDKGPVDAVTGDARYTINEAKLLRESVDTKTLKIR--VIPFEk-----CDESI--DLEVHACD 1396 Caenorhabditi...
XP_009861867 1299 EQAGKPLFLLTKAVHYLVSSAPCDVIAKKAFNSLNEMTLLGTELQYETVVLHatIVEEGg----kVTTSV--DVKVVNVD 1372 vase tunicate
XP_011412156  524 EGGGSSLFMLYKSTQTVVEKRPVDEVTGEAKNTLSEDNFLREKIDCLTMKLE--IDLNGn----gN--LY--TCEVLDCD 593  Pacific oyster
XP_004998121 1579 RDAARPLYNLTQALKIYAWKGPVDAVTGAATYTLNADALLRERVEYEPLTLH--VDM--------NRQVY--EVHVNSCD 1646 Salpingoeca r...
EGT44270     1088 -PQMNSFYNLYKALQFQTDRGPVDAVTGDARYTINEANLLRECVETRTIIVN--VIPLEn-----CHDTV--RLELHSCD 1157 Caenorhabditi...
XP_011667763 1035 KQVAYPLYVLYQAIKGQVDKGPVDAITGQAHFSLNFDYLLDEDVEFEDVTLQ--IVD--------KEHKVleQVKVLDVD 1104 purple sea ur...
XP_011674296  560 RQVAESLYLLYQSIKMQVEKGPIDITTGQSVFSLNFECLLEEEVEFNELTLS--VVGRD------RHHKY--YVKVLDVD 629  purple sea ur...
XP_002113113 1373 GSIGDSLYVLYQAIKQQVDKGPVDEITADAKHSLSEDKLIRQNIDYQTLTLS--AHF--------ERTTE--LVKVLDCD 1440 Trichoplax ad...
XP_011403706 1407 ECAGAPLFVLFKAVKAQLEKGPIDVITGDARNSLSEEKLLRQPLDFKV--CL--FdagvepdpsnADDIQ--TIKVMDTD 1480 Amphimedon qu...

4M8N_A        262 TIQQVKEKILQTFQRKFGFRYTQQIRDIE-----IEY-EKE--GK--FVMLQEVDDTSEIRGH--VTMLNTLKHYQ---V 326  zebrafish
O45657       1397 AICQVKQKVASAVYRETPYSQRPRITQFE-----LKY-KCPk-RG--DVKLTDVLPIETLSQKklPVKLFTLADYG---I 1464 Caenorhabditi...
XP_009861867 1373 SIKQAKTKIIEAVYKDKPYSECPKPDDLD-----FAL-MNSseST--GITLSDVDGMSVVDGK--YTKINTLKHYN---V 1439 vase tunicate
XP_011412156  594 TINQVKSKCLYQIYKNKPASEMPSTDEVD-----LEW-MAGk-SG--RLTLSNIDQTSERGDG--MVRRNTLKHYH---V 659  Pacific oyster
XP_004998121 1647 TIGQILEKL-----KLVVTTAGADVSDFDtrvlvLQR-EEGl------RVLKDIDDSSKMSAG--WVQLNTASFYG---M 1709 Salpingoeca r...
EGT44270     1158 AIRQVKQKVAAAVYYKTPYSQRPRITQFD-----LRF-KCPr-QG--EIRLVEFRTLSKKKL---PVKLLTISDYD---V 1222 Caenorhabditi...
XP_011667763 1105 TITQAKQKILDAVYCKRQTAQQLRSNEVD-----LVL-LNGc-MG--RLVLKDRDPITETRGH--WIKANTIKAYK---V 1170 purple sea ur...
XP_011674296  630 CMTQVKQKILDAAYRNSHIVQQNRAHEMD-----LLWyHPGg-E---ERILKDRDELNKTVGNtkDLFINTVKTYG---V 697  purple sea ur...
XP_002113113 1441 SITQTKEKILDAIYKSAAYSRRTPAEEID-----LEWiRDTp-SGlvRIILKNEDDSSNISGR--WKRINTLKHYQ---I 1509 Trichoplax ad...
XP_011403706 1481 SVSQTKEKLLDFIYGNRPVSKRPSIAEVE-----LEL-CRGn-AG---IPLKDQDTTSRREGE--WMRINTLGHFNileM 1548 Amphimedon qu...

4M8N_A        327 GDGACI----KVITP---------------------------KIhaplkt------qnsvkDDKNFSIKY---------- 359  zebrafish
O45657       1465 SDGCTLemspAVYTAesyrnsladsgqssw-------------------------ssldrcspiyssskY---------- 1509 Caenorhabditi...
XP_009861867 1440 PDNAVV----VLRPHdvenqapqdv-----------------------------------sspllppkhM---------- 1470 vase tunicate
XP_011412156  660 LDNSRM----ALLYK------------------------------------------------------Fspdvehdded 681  Pacific oyster
XP_004998121 1710 RDGDQL----AFVKSdtdggdarrrrnnnssssgggggg-------ggggslfkvrtksksridpmaceP---------- 1768 Salpingoeca r...
EGT44270     1223 QDGSIL----EMTPAfyalenhsqsiadsetl---------------------sctsvdinspaysfleH---------- 1267 Caenorhabditi...
XP_011667763 1171 Syqqqyiyfkidsqkfn--------------------------------------------------------------- 1187 purple sea ur...
XP_011674296  698 SDGCQV----ALIVKasmnetgtyqpvtpgvqlfqqyqe------hagpddvrdrdyirirtmesggsrI---------- 757  purple sea ur...
XP_002113113 1510 PDGASV----VVIPRtsassls--------------vssnssTRypvssrsllgrlsvdenGETHYN--L---------- 1559 Trichoplax ad...
XP_011403706 1549 AEAAIAdp-kKPIPRfrltarnqtlspgrpvsgavgydvpgtIVasasitsqtsllasvnsPSFDTNTRL---------- 1617 Amphimedon qu...

4M8N_A        360 -------------------------------------FHLVDp---DID-TDLs----------------NHPEK----K 378  zebrafish
O45657       1510 -------------------------------------YHLTN----PSSgTMTf---------------kKKSSNdsnlL 1533 Caenorhabditi...
XP_009861867 1471 -------------------------------------YHLIN----PSE-EEQsngytdvqsdagkkadeMLDNL----M 1504 vase tunicate
XP_011412156  682 dtyvnqrspsdvditippnvqliqsvsstgslenlrqWHLVK----NIE-EEDs---------------hEKPSK----L 737  Pacific oyster
XP_004998121 1769 -------------------------------------WHLVK----PDT-DGTa---------------aAAAAA----A 1787 Salpingoeca r...
EGT44270     1268 -------------------------------------YHLVK----STSgSLMc---------------rPKSSTd---V 1288 Caenorhabditi...
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  758 -------------------------------------MHLVAenqmPTE-SSTs-------------------------L 774  purple sea ur...
XP_002113113 1560 -------------------------------------WHLIK----PMD-ENSt------------------DPN----A 1575 Trichoplax ad...
XP_011403706 1618 -------------------------------------FHLVK----PEAnEGDq-------------------------- 1630 Amphimedon qu...

4M8N_A        379 ALKIKEMYLIKLLSTKVAVHSFVENLFKSIWGLp--NNKAPLAVKYFFDFLDEQAERKKITDP-DVLHIWKTNSLPLRFW 455  zebrafish
O45657       1534 PKSIPEVYLTRLLTSKGTVETYVEDFLESVLYMh--DSSYPPILKFFFDILDREASVNGVSE--NICQQWKANGYVLRVW 1609 Caenorhabditi...
XP_009861867 1505 KRPFQEMFLTRMVKAKTTIQEYVDGVFNSILr----PKPISKTVRYFFQFLDREADRHKINDP-EVLHIWKTNSLLLRYW 1579 vase tunicate
XP_011412156  738 KDIGKTSHITNLMHTKLVLQDNIKEVFDSVLN----HETVPLVVHYLFGVLENLANKNSV-EP-DTLLCWKSESYAMRVW 811  Pacific oyster
XP_004998121 1788 TRVPSEIFLTYLMTVKTALQPFVDDLVDAVFNI----DQPSPAVRFLFHFLDDQARKHNISDP-RTTHIWKSNAFPLRFW 1862 Salpingoeca r...
EGT44270     1289 PKSIPEVYLTRLLTSKGTVEAYIEDFFESVLYMh--AYKFPPILKYVFDTLDHEAEINEVED--NISHQWKANGFVLRVW 1364 Caenorhabditi...
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  775 TKLDREFLAPRLLVTKKTIQTRLDEFLACVFKK---PAETPLTIKYLFDFFDKMANKYCDEKSeEIAEAWKSNSLPLHYW 851  purple sea ur...
XP_002113113 1576 NKLVSEVFLTRLLSTKHILQTFVDDLFSQMFTVpqtLYHFPKVIKYLFDFLDYEAFKLGFTTEnDVAHTWKNNCLPLRFY 1655 Trichoplax ad...
XP_011403706 1631 -KIVSEVFLTRLLSTKRIIQSYVDDLFHAIFSVp-aGKSLPRAIKIVFDFLDAQAAENGITDP-EILHTWKTNTLPLRFW 1707 Amphimedon qu...

4M8N_A        456 VNILKNPDFVFsDMEKSPHLDGCLSVIAQAFMDSFSLTDTHLDKHSPTNKLLYGKDIPQYKQEVKSYYKLVKDQTSISSQ 535  zebrafish
O45657       1610 ANFVRNPQLVF-DVPHSISMDANLSTVAQTMMDCFSFSEPVLGAHSPSSRLLFAKDVARLRPLSVDLFKRVKNSPPLGMD 1688 Caenorhabditi...
XP_009861867 1580 VNVLKNPEFVF-DLNKTDIVDSCLNVITQAFMDACTTTNRKLGHDSPSNKLLYAKDADNYKVMVKEFFINISNTPTVTQE 1658 vase tunicate
XP_011412156  812 ATLLVRPEFLF-DIQKARHVEPCLNVIKQVFIDCFHST--KISKDSSLQKLLFAQEVPHYQKKTEQFYKALGNKAAITDA 888  Pacific oyster
XP_004998121 1863 INLIKNPDFLL-HVQQTRTVSSGLSTVAQVIMDSCSVSDQQLGKHSPANKHLYRKEVAEYKQKIANFYTAISRLPPPTDA 1941 Salpingoeca r...
EGT44270     1365 ANFIKNPQLAL-DLPHSISMDANLSIIAQTMIDCFSFSEPVLSAQSPSSRLLFAKDVARLRPFSADLLKRIKNFPSLSIN 1443 Caenorhabditi...
XP_011667763      --------------------------------------------------------------------------------      purple sea ur...
XP_011674296  852 MTTLTHPSYVF-DMRQSRSADQSVSVLANMLDNACKKIRSENTQESALNRVLFYRDLPGHIRTIGEYYENIKGLPPPTTE 930  purple sea ur...
XP_002113113 1656 INIVKNPHHAF-DVNKSGTVDSCLSVIAQAFMDSCSITDNRLGKDSPSNKLLYARETSDYKARVQKFYADIQYMPPVSLD 1734 Trichoplax ad...
XP_011403706 1708 VNLIKNPDFVF-DINKSATIDACFTVIAQAYIDACSTAEVRYTKDTPSARLLYANEVKQYKEEVLQYYRDIMAQPQPTAE 1786 Amphimedon qu...

4M8N_A        536 ELKTFLQEESKKHQNE--------FNESAALRELYKYMQRYFTEI 572  zebrafish
O45657       1689 ELRTELVNMANDVSTC--------KGSSLALSELLSWVRGNGIRI 1725 Caenorhabditis elegans
XP_009861867 1659 EVTQILQKQSASYASR--------FNQMVALNGIYEHLVKYREQV 1695 vase tunicate
XP_011412156  889 DFWSEMSRLSLLQQEHl------kFSKSAALVKLYRFVNQYVEEI 927  Pacific oyster
XP_004998121 1942 ELQASFASAQSGEQAC---------DRPDAVCGLMEYALRFREQL 1977 Salpingoeca rosetta
EGT44270     1444 ELEIELdlstykgsslalsellswvrgnairitehlssceksaqq 1488 Caenorhabditis brenneri
XP_011667763      ---------------------------------------------      purple sea urchin
XP_011674296  931 ELQEDFNRITQDFSGL--------FSRVATLNKLYDFTShdtgpl 967  purple sea urchin
XP_002113113 1735 ELLHTHEDMMRRFRVKr------nFNSLNAVHELFTYATKYITEl 1773 Trichoplax adhaerens
XP_011403706 1787 DNKSYFQEMAENYFQSfeskeglhFHSDSALLEIYRYAIQYGDDI 1831 Amphimedon queenslandica
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