2DAX,2DAY,2EBM,1UKX,2EBK


Conserved Protein Domain Family
RWD
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pfam05773: RWD (this model, PSSM-Id:283440 is obsolete and has been replaced by 399058)
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RWD domain
This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Links
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Statistics
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PSSM-Id: 283440
Aligned: 121 rows
Threshold Bit Score: 39.5972
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DAX_A          8 EQAEAQLAELDLLASMFPGENelivndqlavaelkDCI-----EKk--TMEGrSSKVYFTINMNld----vSDE------ 70   human
Q4CVK5        246 SLDAACEEEIGLLTSMYGEEC--------------VQR-----N----KTPV----VFLPLLLDgv----sDEA------ 288  Trypanosoma c...
Q4D6B4          2 avpDDNAEEVELLLSISPEVV--------------CRD-----PT---HSST----LVFLLPFR---------------- 39   Trypanosoma c...
Q4QCY6          3 ppTEMQEMEMEMVQGMY-DTY--------------ERL-----SD---DPPS----YCVSLAAT---------------- 39   Leishmania major
Q4DGH6          2 paTEMQSMEMDTVQSMYDSYEl-------------ISV-----DP-----------PTYSVLLT---------A------ 37   Trypanosoma c...
Q8T6F6         41 FCRDLQDNEVQTLHYLGLPYV--------------VLA-----RR---PRLR----VKVPLSTIn------YEI------ 82   Drosophila ps...
Q8MZ95         27 YFRDLQENEVRTMHYLGLAYV--------------VLS-----RR---PNLQ----LKVPLSTQnyedgasVGA------ 74   fruit fly
Q4CY49        190 EGDAILENELETMQSLFDESF--------------LGV-----KQideKEFE-GREMYFSFSSG---------------- 233  Trypanosoma c...
XP_002641128    4 DDRETQLFELEALESVLRENK--------------VTKtsdwtDE---NAEI-EGTIEVGFDSI-------SDPkvtltg 58   Caenorhabditi...
XP_961050     437 DADECWEEEMATLEACFGEKF--------------SKI-----S----PEIC-----EIKLEGV--------KN------ 474  Neurospora cr...

2DAX_A         71 ----------KMAM---FSLACILPFK-YP-AVLP-EITVRSVL------------------LSRSQQTQLNTDLTAFLQ 116  human
Q4CVK5        289 ----------SDMSlsaLRICMTLPRR-YP-AELP-KLDVVGGPaah------------hvfFERWKLQLITKTLAYLRD 343  Trypanosoma c...
Q4D6B4         40 -----------------FVLHVTLPPRgYPdVSRP-SLFVAAGP-------------------NAHLVNQFSSQLNKALR 82   Trypanosoma c...
Q4QCY6         40 -----------QDEppqLRVIITYPTEeYP-ESAPcVVAVECISk-----------------ARRIQVGAITKQVASICE 90   Leishmania major
Q4DGH6         38 ----------TADDppeLRVTIVYDSEgYPeTAAP-TVRLEHIAk-----------------HRRMQTAALAKEIEDLCA 89   Trypanosoma c...
Q8T6F6         83 ----------GQWVgiaMQLLFTCPSN-YP-MQRP-LVEIVEKRn-----------------VSIALEWALHEEIVQSLD 132  Drosophila ps...
Q8MZ95         75 ----------GERGgyaLQLLFTCAAN-YP-LARP-LVEIVEKRn-----------------VSDAFEQVLRKEIDLILE 124  fruit fly
Q4CY49        234 -------------SgkrVVVCVRVPNQ-YP-ADPP-LILVQPCGnqvgtlpilgvfhadtkeLPAALRRSILDAAVETIN 297  Trypanosoma c...
XP_002641128   59 tsesgdefsvSLDIlppVRLKFKLPKD-YPsDSSP-KLELESDW------------------MNQEQRKMCESELSKICE 118  Caenorhabditi...
XP_961050     475 ----------GSQTnvdACVQFRKSEQ-YP-TQV--ILAMVAAL------------------PSYIKLSVIKQALAYALT 522  Neurospora cr...

2DAX_A        117 KHc-HGDVCILNATEWVREHA 136  human
Q4CVK5        344 DLg-VGNAMLLPAMMFAGEQA 363  Trypanosoma cruzi
Q4D6B4         83 EEvpLGGPMLLHIFTLAQDIA 103  Trypanosoma cruzi
Q4QCY6         91 EN--IGMHSVVLALQQVQDFL 109  Leishmania major
Q4DGH6         90 EQ--IGMHSVISVLQKAQEYL 108  Trypanosoma cruzi
Q8T6F6        133 QH--IGLQMIAPVTIRLQTLL 151  Drosophila pseudoobscura
Q8MZ95        125 EH--LGLQMIVPVVTRLQITL 143  fruit fly
Q4CY49        298 GF--AGEGCLVALMSSLHGVI 316  Trypanosoma cruzi
XP_002641128  119 EN--LMMGVLYLCYQGIIDLI 137  Caenorhabditis briggsae
XP_961050     523 LE--GEEMKIFYVASWVQENI 541  Neurospora crassa OR74A
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