Conserved Protein Domain Family
RTA1
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pfam04479: RTA1 (this model, PSSM-Id:282350 is obsolete and has been replaced by 461325)
RTA1 like protein
This family is comprised of fungal proteins with multiple transmembrane regions. RTA1 is involved in resistance to 7-aminocholesterol, while RTM1 confers resistance to an an unknown toxic chemical in molasses. These proteins may bind to the toxic substance, and thus prevent toxicity. They are not thought to be involved in the efflux of xenobiotics.
Links
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Statistics
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PSSM-Id: 282350
Aligned: 264 rows
Threshold Bit Score: 139.509
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4WUW4        57 LVLGGICETFGYYGRAWSHKEgrtaIGPWALQEMLILCAPPFVAASIYMVLGRIICAFd-A---E--HHSS--IRTKWLT 128 Aspergillus fum...
ENH69058      78 aIMGATWETIGFAFKTLGSRNqq-nMTYLIWGQLFFLLAPLWINAFVYMAVARMVYFRmpD---R--KLLG--IKAIRMT 149 Fusarium oxyspo...
EMR84474      53 IIVSGIAQTLAYIFRVISIKNpa-sFGNYAAWFILILIAPLFTNAFAYMVMGRMIWNYviE---A--KIWK--ITAWRFG 124 Botryotinia fuc...
XP_011323769  73 aIMGATWETIAFAFKTLGSHDqq-nLTYLTVGQILFLLAPLWINAFVYMGVARMV-YF--GmpsQ--KLLG--IKAVRMT 144 Fusarium gramin...
EHK48506      52 IIMSALWQTLTYIFRTISIQNpa-sYGNYAAWFVLILVAPLWTNAYAYTLFGRMVWAY--Ta-tH--KLWR--IKAWQFG 123 Trichoderma atr...
XP_003721345 110 LIMGGIWESAAFTVHAIGAKDqq-sEPLAVGYSMLYLLAPLWITAFVYMTFARQVWYWtpD---Q--RLFM--LSAHVLS 181 Magnaporthe ory...
EPE04416      52 IIMSSLWQFLTYIFRALSIQtp-asFGNYAAWFVLILIAPLWTNAYSYMVFGRLVWNYtpD---R--KVWG--LRAQRFG 123 Ophiostoma pice...
XP_001597554 145 IVAASIWGLTAFILRVLSTHDqqdtVLELLSSIFALTISPV-INAYYYILLGRIVHHY--L---T--NRSLlgIRAQFLA 216 Sclerotinia scl...
XP_008084566  63 IVASGMAQTLAYVLRILSILNpa-sFGFYAGWFVLILVAPLFTNAFVYMVMGRMIWNY--V---PekKIHR--VTAWRFG 134 Glarea lozoyens...
ERS95305      58 IVMSVLWQLLTYIFRTISIQtp-asFGDYAAWFVLVLIAPLWTNAFAYMVFGRLVYNYtpD---R--KLWG--VPASRFG 129 Sporothrix sche...

Q4WUW4       129 TIFVLNDVVCFLTQLAGAGV-Q-IT--GDPH-V--M-AIGKKAVLAGLIFALVVFGVFVWVAAAFHRRLDaeptavvrE- 199 Aspergillus fum...
ENH69058     150 LLFVWLDIILFLVQGAGGSM-L-SN--NDDM-Nv-I-RIGQKLYMAGVGLQLAVIVIFIGITAFFYFKLRql-----eG- 216 Fusarium oxyspo...
EMR84474     125 LYFVILDVAALLIQIYGAAT-A-AS--DNASaDe-T-LQGLHVYMVGVGIQQFFIFVFLFFAFKFH-QTLrsqsrqnvY- 196 Botryotinia fuc...
XP_011323769 145 LLFVWLDVILFLVQGTGGVM-L-SN--TDAD-Sd-TiDIGMKVYMAGVALQLAVVLVFSGITVFFYFKLRql-----eG- 212 Fusarium gramin...
EHK48506     124 FIFILLDIVAFVVQVVGAVQaT-GS--NTTD-Qq-V-LNGLHIYMGGVGLQLVFILIFCIYALRFYLETRqspd------ 191 Trichoderma atr...
XP_003721345 182 KVFVLADVLAFVLQFLGAAL-V-TNhkAKTP-Ee-I-RRGAILHLAGLSLQLTVTAIFLVLMAAWHLKMIayeaerahLd 256 Magnaporthe ory...
EPE04416     124 VIFVMLDIVAFIVQVYGAAA-A-SA--KDAA-TddV-LRSLHIYMAGVGIQLFFLLICFVFGIRLWLMMRtdaimyphL- 196 Ophiostoma pice...
XP_001597554 217 LPFLVINAAAFVLEVVGATM-M-DK--RNLV-We-Q-RNADHLYTGGLVVQMLVNFVFMGMLFALLFEMRnsgr------ 283 Sclerotinia scl...
XP_008084566 135 MYFVVLDVCALVIQIIGAVQ-A-TG--ENTT-Tk-QvLRGLHMYMGGVGVQLGFILLFLFFAVKFHRIVRqqnstsfgS- 207 Glarea lozoyens...
ERS95305     130 LLFVVLDIIAFVIQVYGAAT-AsAN--GIPE-De-V-LRDLHVYMGGVGVQLLFILICSVFGIKLWTVMRreakqsprA- 202 Sporothrix sche...

Q4WUW4       200 ---------CPRLRWKKYMWVIYVSCGMLMV----------------RNLVRTVQFGS---R--K-G--SALNTEEAFIY 246 Aspergillus fum...
ENH69058     217 ---------RSMGRMKWLILTMLAVLILIVI----------------RIVYRLIEFGP---G--V-NehNQLLIHEEYPL 265 Fusarium oxyspo...
EMR84474     197 ---------TSRQAW-SLLYVLYAVILLITI----------------RIIFRLVEYSQ---G--L-K--SSIPNHEAFQY 242 Botryotinia fuc...
XP_011323769 213 ---------RSMGCMKWLIWTMVAVLMLIVVgilcpftcyqadkvktRIVYRLVEFGP---G--V-NahNTLLIHEGYPL 277 Fusarium gramin...
EHK48506     192 -----------arqaQVLFYAQILALAMIVL----------------RIIFRICEYSQ---G--L-D--SKIPNHEAYQY 236 Trichoderma atr...
XP_003721345 257 pygdcspegPIRRSWKFLHAAMYIAVLLIAI----------------RLCFRLAESGQivvG--StR--GGLASSQILQY 316 Magnaporthe ory...
EPE04416     197 ---------RPAL---MLLYVQFVVLVLIIV----------------RIVFRIVEYSS---G--L-K--SSIPLHEAYQY 240 Ophiostoma pice...
XP_001597554 284 -------rsvMRTRWKGLVGAMFGASGLILI----------------QIFFSLGRFSA---GdkS-F--SALSSHESYFY 334 Sclerotinia scl...
XP_008084566 208 ---------PGLTHALILLYNLYTVLGFIIL----------------RIIFRLIEYAQ---G--L-D--SGIPNKEGYQY 254 Glarea lozoyens...
ERS95305     203 ---------LRPAL--LLLYVQFAVLALIII----------------RIIFRIVEYAS---G--L-K--SSIPNHEAFQY 247 Sporothrix sche...

Q4WUW4       247 VFDAALMAGSILVLIVWHPGRLVRR 271 Aspergillus fumigatus
ENH69058     266 GLDATPILIALVLLNIMHPGFVLRG 290 Fusarium oxysporum f. sp. cubense race 1
EMR84474     243 SLDSVPMLFALVFLNIFHPGRIMad 267 Botryotinia fuckeliana BcDW1
XP_011323769 278 GLDATPILIALVLLNIMHPGFVLRG 302 Fusarium graminearum PH-1
EHK48506     237 CLDSLPMFIALVVYNVVHPGRIMRG 261 Trichoderma atroviride IMI 206040
XP_003721345 317 LLDAAPVMLCLAVLAVAHPGRFLIG 341 Magnaporthe oryzae 70-15
EPE04416     241 SLDTLPMFLALLMYNIVHPGRIMQG 265 Ophiostoma piceae UAMH 11346
XP_001597554 335 ILETTPVVLAIAILNVFHPGRFMTG 359 Sclerotinia sclerotiorum 1980 UF-70
XP_008084566 255 GLDSLPMLIALVLLDAFHPGRIMKG 279 Glarea lozoyensis ATCC 20868
ERS95305     248 ALDTLPMFVAIVLYNIVHPGSIMRG 272 Sporothrix schenckii ATCC 58251
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