Conserved Protein Domain Family
Tropomodulin
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pfam03250: Tropomodulin (this model, PSSM-Id:281268 is obsolete and has been replaced by 460862)
Tropomodulin
Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.
Links
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Statistics
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PSSM-Id: 281268
Aligned: 31 rows
Threshold Bit Score: 180.094
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q173S8        21 YGKDLGAYDD--VDVDELLSQLSPEEITMLAKEVDPDDSFLPPSQRTNYECTKDPTGPLDRKKLIDHINKQALETPDKPE 98  yellow fever mo...
O46231        19 YGKDLSEYDD--VDVESLLAQLSPEEITILAKEVDPDDNFLPPDQRNSYECTKEATGPLNRKQLIEHINKQAIETPDQPE 96  fruit fly
XP_006560803  51 YGKDLSEYDD--VDVDDLLAQLTPEEINILAKEVDPDDSFMPPSQRCSYECDKSPTGPLNRKKLIEHINKQALETPDRPE 128 honey bee
EHJ67678       8 YGRELSAYDE--VDVDELLSKLSQEELTMLAKEVDPDDNFLPPSQRNNYACEKDPTGPLNRKKLIEHINKQALETPDRPE 85  monarch butterfly
XP_008194396  43 YGKDLSEYDE--IDVDELLNKLSAEEINILAKEVDPDDTFLPPSQRCSYDCEKEATGPLNRKQLIEHINKQAIETPDKPE 120 red flour beetle
XP_003242369  93 YGKNLSDYDE--LDVDQLLSQLSPEEISILAKEVDPDDNLLPPSERCSYECNKEATGPLNRKKLIEHINKQALETPDLPE 170 pea aphid
EFX74286       7 YGKELKEFDD--VDVDDLLTQLSAEELEILSKEVDPDDRFMPPDQRTNYHCEREATGPVDRKQLIDHINKIALETPDQPE 84  common water flea
CDS29481       7 FGKALDKYDSnlDDIDELLSKLTEDEIKALNDDIDPDNSLLPPSQRCRDQTTKAPTGPYDREKLIKFLVEKAKNDPDWDE 86  Hymenolepis mic...
GAA27593       7 FGKELASYDD--EDLDELLSKLTEEEIQQLNDDLDPDNTLLPPSQRCRDQTTKAPTGPFNREKLLKFLIDKAKSEKDWEE 84  Clonorchis sine...
CCD79981       7 FGKALTSYDD--EDIDELLSKLTPEELEQLNDDFDPDNSLLPPSQRCRDQTTKTPTGPFDREKLLRYLIEKAKAEKDWEE 84  Schistosoma man...

Q173S8        99 LEPFvPGTVRGKKWIPPP-MERKLQEAAE------QiaIDMGDEYEQALNDATQEEIIDLAAILGFHSMMNQ 163 yellow fever mosquito
O46231        97 FEPFvQGKVRGKKWVPPP-RDARDIEAEE------QiaIDMGEEYEHALNDATQEEIIDLAAILGFHSMMNQ 161 fruit fly
XP_006560803 129 LKPYvPGVIRGKKWVPPPqESTKEKEAEE------QiaIDLGEEYEQALSNATQEEIIDLAAILGFHSMMNQ 194 honey bee
EHJ67678      86 VKPYvPGVVRGKKWIPPP-PSEKVRDAEE------QitIDLGDEYEQALSTASQEEIIDLAAILGFHSMMNQ 150 monarch butterfly
XP_008194396 121 LKPYvPGTVRGKKWIPPP-PPVKEQEADE------QiaVDLGDEYEQALSLATQEEIIDLAAILGFHSMMNQ 185 red flour beetle
XP_003242369 171 IKPYvAGTVRGKKWVAP--ETNGNTEHED------KiaIDIDDEYGDALNTASQEEIIDLAAILGFHSMMNQ 234 pea aphid
EFX74286      85 SVPFvAGVVRGKKWIPPE-APVIVSREDD------GvsFNLEDEYEQALGTATEEELVDLAAILGFHSMMNQ 149 common water flea
CDS29481      87 AVPY-EKKIRGKVFQK---KAEEPKKMEKdeladlGfdVEFDENINEALNNATDDELIDLAAILGFTGMMNQ 154 Hymenolepis microstoma
GAA27593      85 AVPY-EKVTRGKVYVP---KREQVQVSQKels-dmGfdVEFDQEVNEALENATEDELVDLAAVLGFTGMMNQ 151 Clonorchis sinensis
CCD79981      85 AVPY-EKKKRGKVYTP---KQIMSPSTQNelv-emGfdVEFDDDVNKALENATEDELVDLAAVLGFTGMLNQ 151 Schistosoma mansoni
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