1V31,4HBM,1UHR


Conserved Protein Domain Family
SWIB
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pfam02201: SWIB (this model, PSSM-Id:280380 is obsolete and has been replaced by 460488)
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SWIB/MDM2 domain
This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.
Links
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Statistics
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PSSM-Id: 280380
Aligned: 379 rows
Threshold Bit Score: 39.3674
Created: 21-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V31_A        10 EKFKLSTALMDVL-G-----IEveTRPRIIAAIWHYVKARKLQNPNDPSFFNC-DAALQKVFG-EeKLKFTM-VSQKISH 80  thale cress
Q6P3Q9        22 klVKPTPLLLSLL-KsagaqKEtfTMKEVIYHLGQYIMAKQLYDEKQQHIVHCsNDPLGELFG----VQEFS-VKEPRRL 95  western clawed ...
XP_009519660 363 KLYKLSPSLSHLL-G-----KSelTRPAAIKEFWAYVKEHKLQDPKDGRLIHP-NQEMKDVFSvD-EIGFTQ-VMGLLSK 433 Phytophthora sojae
CDI77656     135 RPVRLSAALQQLLqL-----PLysSKVDVIRGLWGYVKQQQLQQQGAPHIVCC-NQQLQQLFGgLeSVNLFSdINRLLLP 208 Eimeria acervulina
4HBM_A        21 tlVRPKPLLLKLL-KsvgaqKDtyTMKEVLFYLGQYIMTKRLYDEKQQHIVYCsNDLLGDLFG----VPSFS-VKEHRKI 94  human
XP_005039489  22 alVKPKPLLLKLL-KlagaeKDtfTMKEVIFYIGQYIMSKQLYDEKQQHIVHCaNDLLGDLFG----VASFS-VKEHRRL 95  collared flycat...
XP_011371319  25 kqVRPKLPLLKIL-QaagaqGEifTVTEVMHYLGQYITMKQLYDPREQHMVYCgGDLLGELLG----CQSFS-VKDPSPL 98  large flying fox
XP_006633639   1 mqVKPKTKLHALL-QhagadKDifTMKEIMFYLGQYIMDKQLYDKKQQHIVHCtNDLLGDVLG----VNSFS-VKEPRNL 74  spotted gar
O42354        19 klVRPKVQLKSLL-EdagadKDvfTMKEVMFYLGKYIMSKELYDKQQQHIVHCgEDPLGAVLG----VKSFS-VKEPRAL 92  zebrafish
XP_011130390  82 RVYRLSPMLSQLL-D-----KTalSRSQAIKLIWKYIKDHDL---NDGHVIAC-DKALRTCFd-TdYLHFFS-LTAYLTP 149 Gregarina nipha...

1V31_A        81 HL 82  thale cress
Q6P3Q9        96 YA 97  western clawed frog
XP_009519660 434 HL 435 Phytophthora sojae
CDI77656     209 HI 210 Eimeria acervulina
4HBM_A        95 YT 96  human
XP_005039489  96 YS 97  collared flycatcher
XP_011371319  99 Ya 100 large flying fox
XP_006633639  75 YA 76  spotted gar
O42354        93 Fa 94  zebrafish
XP_011130390 150 HL 151 Gregarina niphandrodes
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