Conserved Protein Domain Family
MAGE
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pfam01454: MAGE (this model, PSSM-Id:279759 is obsolete and has been replaced by 426270)
MAGE family
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Links
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Statistics
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PSSM-Id: 279759
Aligned: 110 rows
Threshold Bit Score: 98.8162
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5KFQ9        49 LVRLALFQ-EYKRIPIRR-------TEVAKqILPDn---TRAF--PLVFARAQTILRDTFGCELYEIRARGKGESTEDPS 115 Cryptococcus ne...
Q5AFD4        60 VVRLFLSR-ELNGRTTRP-------DVIRK-HIKHnlgrKITT--EKLIQQANIILTEVYGLKIEEVPTIKREDKKSSKS 128 Candida albicans
Q6BHM0        43 VIRYVMSR-ELKSQIIRR-------EHITQ-LYSNr---RINY--DALITRVKLTLKEVYGLTLVVVPPKRGDKKNKSSH 108 Debaryomyces ha...
XP_007372871  44 VIRLVLTR-ESKGQLIRR-------EHINQ-IINDr--kNRSY--DVVLKEVTVALEEAYGLTLVETPIIKKKGDTSKAK 110 Spathaspora pas...
XP_003681788  26 LARVVLSVvESQNTIISRprlqkmaKEIAEk--EEy--gTVRF--NEIFQEMNAILNDVYGYELKTLPPRVANPAGDQPD 99  Torulaspora del...
XP_001384110  11 VVRLILGR-ELKSQFIRR-------EKISSeVNTKr--hG--L--DLIIKRVNAELEKVYGLTLVETPP--EKKSRVTKT 74  Scheffersomyces...
CCE41206      84 IVKLILTK-DARGQNFQK-------QHINQyL--Tn--kRFKS--DSLLDDAIAILENVYGLTLVDAPTAKQEKKFNASH 149 Candida parapsi...
XP_002545705  63 VVRLALAK-ELNGKKLRT-------DHIAk-AIKHn--fGRKVtgNVLIKEANKILQEVYGLSLEDVSSSTDKQKTKPES 131 Candida tropica...
XP_002619647  49 LLRMVMTR-SARNQKIRR-------EHFTAiLHKHn--vKGNT--KAIISQVDAELKEVFGLKLDQ-------------- 102 Clavispora lusi...
EMG48242      60 VVRLFLTR-ELLGKPSKP-------DVIRKfV-KHn--lGRKFttDMLIQQADVVLKDVYGLAIQETPNLNNAKKQDQQQ 128 Candida maltosa...

Q5KFQ9       116 QTqamtqtqkkgkgkgrqpnrgldaideeeeeedeeeedatitqkvkretG-------------------------TKV- 169 Cryptococcus ne...
Q5AFD4       129 RKvt----------------------------------------------------------------------sdKNP- 137 Candida albicans
Q6BHM0       109 SNg-------------------------------------------------------------------------KQQ- 114 Debaryomyces ha...
XP_007372871 111 KVl----------------------------------------------kP-------------------------KQP- 118 Spathaspora pas...
XP_003681788 100 SSs----------------------------------------------tK-------------------------TQR- 107 Torulaspora del...
XP_001384110  75 TNv----------------------------------------------kV-------------------------KQP- 82  Scheffersomyces...
CCE41206     150 GDq----------------------------------------------rNvidtsnanggvnggngdkitkktppRNR- 182 Candida parapsi...
XP_002545705 132 DQp----------------------------------------------aT-------------------------KMRk 140 Candida tropica...
XP_002619647 103 --------------------------------------------------S-------------------------TND- 106 Clavispora lusi...
EMG48242     129 QQp----------------------------------------------qQtqeqqpkk----------prkaageRNA- 151 Candida maltosa...

Q5KFQ9       170 ------YILQNI------LP-G-----------------KIieam--------------------aepaPLPHGIEVE-- 197 Cryptococcus ne...
Q5AFD4       138 ------YIVTSS------LS-S-----------------KSrail--------------------gelwNKNLAK-NV-- 164 Candida albicans
Q6BHM0       115 ------LMLTNC------LS-P-----------------EGrivl--------------------qeiwLTDSEAGIP-- 142 Debaryomyces ha...
XP_007372871 119 ------YAVVNC------LT-P-----------------EArnll--------------------gdiwEKSLGTFTK-- 146 Spathaspora pas...
XP_003681788 108 ------YILLDNnasidqLN-DlilaqnesiyvqtvqngEYigdrl------------------afestNTIDNKLSV-- 160 Torulaspora del...
XP_001384110  83 ------FAIVSC------LE-P-----------------KSkkvl--------------------gelwQTSTNVNPE-- 110 Scheffersomyces...
CCE41206     183 ------FFLVSN------LSqP-----------------AQqvlg---------------------dlwMTTVNSSLDkt 212 Candida parapsi...
XP_002545705 141 tsgkgpYVMVST------LS-V-----------------QSrnil--------------------gelwNKDLRISF--- 173 Candida tropica...
XP_002619647 107 ------IVLVSN------LQ-K-----------------DTklllqklvengdgsefkgnpydtfyfmnKEKRNETTV-- 154 Clavispora lusi...
EMG48242     152 ------FIVVSD------LS-P-----------------QArnvl--------------------gelwQRDLARVTK-- 179 Candida maltosa...

Q5KFQ9       198 -------------------GDD---------------------DDSgallqwdkg----dggiighvgL----------- 222 Cryptococcus ne...
Q5AFD4       165 -------------------KKI---------------------DIGgnkfflpkysitsvpgshyelvK----------- 193 Candida albicans
Q6BHM0       143 -------------------NNR---------------------NSGdnqyflpkynktsslgsntdmvK----------- 171 Debaryomyces ha...
XP_007372871 147 -------------------NDDlgqskfyvprysksklptsnyELV----------------------K----------- 174 Spathaspora pas...
XP_003681788 161 -------------------DQ----------------------DQT----------------------F----------- 166 Torulaspora del...
XP_001384110 111 -------------------ADA---------------------HGS----------------------Kyfvpkykkteg 128 Scheffersomyces...
CCE41206     213 kigdtrfflpkfkqsilpkSNS---------------------DLV----------------------K----------- 238 Candida parapsi...
XP_002545705 174 -------------------KKP---------------------DLT----------------------S----------- 180 Candida tropica...
XP_002619647 155 -------------------SMS---------------------DSI----------------------F----------- 161 Clavispora lusi...
EMG48242     180 -------------------KTD---------------------INT----------------------S----------- 186 Candida maltosa...

Q5KFQ9       223 ---------L---------------------GIRT----------------------LILSLVLCHNRIINDDHLHALLR 250 Cryptococcus ne...
Q5AFD4       194 ---------T---------------------GIML----------------------VIISHIILNENHVSESALLKTLH 221 Candida albicans
Q6BHM0       172 ---------T---------------------GVTL----------------------LIMSLLIISENHMSEYELVNGLK 199 Debaryomyces ha...
XP_007372871 175 ---------N---------------------GILL----------------------VIVSLIILSENHISESELFRNLR 202 Spathaspora pas...
XP_003681788 167 ---------K---------------------GLLS----------------------VILCTVLFSKNNILQQELFEHLQ 194 Torulaspora del...
XP_001384110 129 plsnielvrT---------------------GIML----------------------YIVSMLILAENYLSEDDLERGME 165 Scheffersomyces...
CCE41206     239 ---------T---------------------GIMM----------------------LVTTLVILSENHIMESQLIRSLR 266 Candida parapsi...
XP_002545705 181 ---------K---------------------GFFLplyektpapgshydlvktgimlLIISMIILNENHIQETILLTKLK 230 Candida tropica...
XP_002619647 162 ---------G---------------------GIIM----------------------LLIGLVIVNENRIRESDLLDGLS 189 Clavispora lusi...
EMG48242     187 ---------KfflpkynkscipgshhqlvkdGIML----------------------VIISIIILNENHIQEDALLKSLR 235 Candida maltosa...

Q5KFQ9       251 RLNLHRETVLpyaskdTTDPHLTLDKYLELLAKYQYLEKIKNpgpM-GQAE-GG-TVEWKWGSR-EAEFSSK 318 Cryptococcus neoformans
Q5AFD4       222 KFGISSNLNVk-----NSNFNLNSQELLKELVNKDYILKNVIk--G-RTES-EN-IFDYSIGQRsLVEFSPQ 283 Candida albicans
Q6BHM0       200 RFGLSDHPNFk-----NSSFNASLPDLINELVKKEYLDKEVQ---K-DSNN-VE-NVDYKLGRRsLVEFTPL 260 Debaryomyces hansenii
XP_007372871 203 KFGISTNLNVk-----NSSLNMNIQELLNDLIRREYLNKNIT---KgRIES-EN-VVEYTLGRRsLIEFPPQ 264 Spathaspora passalidaru...
XP_003681788 195 KFGVPTDGSPi-----PIINIPILE-LLKTLDKLEYLSRHQE---H-TDLD-LE-TVTYRIGRRtQAEFPLD 254 Torulaspora delbrueckii
XP_001384110 166 RMGISKDSNKr-----NSNLGMNLQELVSDLIKKDYINKEVS---K-GTVEsEN-RVIYSLGRRsLVEFPPQ 227 Scheffersomyces stipiti...
CCE41206     267 KFGISDNNAMk-----NSNINMNWEDVLKELVSREYLTKLQL---A-DSEK-DK-IYAISLGRRsLAELEPt 327 Candida parapsilosis
XP_002545705 231 KFGISDNLNQk-----NSNINMNSKDLLNDLTDKEYLSRKKL---KgRTES-ED-IHDYSLGKRsLAEFTPQ 292 Candida tropicalis MYA-...
XP_002619647 190 QFGFSENLNIv-----VPNLNKTTQEVLTEATKKEYLQKLVA---Q-AHGG-EPaIVSYALGKRtLREFDAH 251 Clavispora lusitaniae A...
EMG48242     236 KVGLPPSLNVk-----NSNLNMNTVELIKELKDHDYLSENVI---KgSSES-EN-IIDYSLGKRsLVEFTPH 297 Candida maltosa Xu316
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