Conserved Protein Domain Family
Myc_N

?
pfam01056: Myc_N (this model, PSSM-Id:279405 is obsolete and has been replaced by 460045)
Myc amino-terminal region
The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see pfam00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest.
Statistics
?
PSSM-Id: 279405
Aligned: 19 rows
Threshold Bit Score: 346.381
Created: 21-Jun-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P52160         2 PvsaSLACKNYDYDYDsIQPYFYfdNDDEDFYhhqQGQTQPSAPSEDIWKKFELLPTPPLSPSRRQSL------------ 69  zebrafish
Q9Z304        10 P---GMICKNSDLEFDlLKPCFY--PEEDDIY---FGGHNSTPPGEDIWKKFELLPTPRLSPDSALAEhs---------- 71  house mouse
Q63379        10 P---GMICKNPDLEFDsLQPCFY--PDEDDFY---FGGPDSTPPGEDIWKKFELLPTPPLSPSRAFPEhs---------- 71  Norway rat
P18444         2 P---GMISKNPDLEFDsLQPCFY--PDEDDFY---LCGPDSAPPGEDIWKKFELLPTPPLSPSRAGLQepppgggsia-- 71  chicken
AAA36371       2 P---GMICKNPDLEFDsLQPCFY--PDEDDFY---FGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAE------------ 61  human
NP_068609     10 P---GMICKNSDLEFDsLKPCFY--PEDDDIY---FGGRNSTPPGEDIWKKFELLPTPRLSPGRALAE------------ 69  Norway rat
XP_005319419  10 P---RMICRNADLEFDwLQPCFY--PDEDDFY---FSGPNSTPPGEDIWKKFELLPTPPLSPSCAFLEl----------- 70  thirteen-lined ...
EFB21123      10 P---GMICKNPDLEFDsLQPCFY--PDEDDFY---FGGPDSTPPGEDIWKKFELLPTPPLSPSRAFPE------------ 69  giant panda
XP_008115524   2 P---GMVSKNPDLEFDsLQPCFY--PDEDDFY---LCGPDSAPPGEDIWKKFELLPTPPLSPSPAGLQenppggvagswg 73  green anole
XP_006634423   2 plnsSLSSKNYDYDYDsIQPYFYidNDDEDFYqqqHSQLQPPAPSEDIWKKFELLPTPPLSPSRRPSLssl--------- 72  spotted gar
P52160        70 ---------STAEQLEMVSEFLG----DDVVSqsficdDADySQ----------SF-----------IKSIIIQDCMWSG 115 zebrafish
Q9Z304        72 -----------lEPVNWATEMLLp--eADLWS------NPGeEE----------VFgqggl--rgctSNPIILQDCMWSG 120 house mouse
Q63379        72 -----------pEPSNWATEMLLp--eADLWG------NPAeED----------AFglggl--ggltPNPVILQDCMWSG 120 Norway rat
P18444        72 vgrggpgecRPVDPLDWASELLLlppeAELWG------STDgAD----------FFetglg--asnnLNSIIIQDCMWSA 133 chicken
AAA36371      62 ---------HSSEPPSWVTEMLLe---NELWG------SPAeED----------AFglggl--ggltPNPVILQDCMWSG 111 human
NP_068609     70 ---------DSLEPANWATEMLLp--eADLWS------NPAeEEdifglkglsgSS-----------SNPVVLQDCMWSG 121 Norway rat
XP_005319419  71 ----------sTEPSDWASEMMLs--eADLWD------NPDeED----------VFgpegl--gsltPNPVILRDCMWSG 120 thirteen-lined ...
EFB21123      70 ---------HSPEPPNWATEMLLp--eADLWG------NPAeED----------AFglggl--ggltPNPVILQDCMWSG 120 giant panda
XP_008115524  74 aavaalggfRTSDPLDWASELLLlppeADLWG------NNDgGD----------SFeiglgesinsnLNAIIIQDCMWSG 137 green anole
XP_006634423  73 -------vpSTADQLEMVTEFLG----DDVVSqsf-icDADySQ----------SF-----------LKSIIIQDCMWSG 119 spotted gar
P52160       116 FSAAAKLEKVVSERLASLHAERKELMS-------------------DSNSNRLNasyLQDLstsASECIDPSVVFPYPLT 176 zebrafish
Q9Z304       121 FSNPGKPESVVSEKLPGGYRSLAVGAGtlapgaaaaassaghersgTAGVGRGKaawLTELshlDLECVDPAVVF-FPAN 199 house mouse
Q63379       121 FSAREKLERAVNEKLQHGHGPPGASSScpapgvgas-ssggralggSASAGRTGatlPTDLshpAAECVDPAVVFPFPVN 199 Norway rat
P18444       134 FSAREKLERAVSEKLQSKPPAAAPPPPppvvptaa---crrreqpqRGPG-------RAELggsVPECVDPAVVFPFPVN 203 chicken
AAA36371     112 FSAREKLERAVSEKLQHGRGPPTAGSTaqspgagaa-spagrghggAAGAGRAGaalPAELahpAAECVDPAVVFPFPVN 190 human
NP_068609    122 FSSREKPETVVSEKLPGGCGSLAVGAGtlvpgaaaa-tsagharsgTAGVGRRKaawLTELshlDSECVDSAVIF--PAN 198 Norway rat
XP_005319419 121 FSAREKLERAMSEKMQHGHEPAATGPAtqvpgagaa-spagrghsgTTGaa-----lPAELahpAAKCVDPAVVFLLPVS 194 thirteen-lined ...
EFB21123     121 FSAREKLERAVSEKLQGSAGGRGPASSkpspgm--------mrrggVEAARRVFpkvSSSLkflPPCPGAPLDHWPSPVP 192 giant panda
XP_008115524 138 ISASEKLERVVHEKLQGKGGGLPATAAgsatlavg---tatavsstTPSSTGNNgssQAELnnsVSECVDPAVVFPFPIK 214 green anole
XP_006634423 120 FSAAAKLEKVVSERLASLQAARKEAAC-------------------EIPGNKLNatyLQDLntsASECIDPSVVFPYHMS 180 spotted gar
P52160       177 ECG-------------------------K---------------------Agkvaspq-------pmlvldtPPNS---- 199 zebrafish
Q9Z304       200 KRE-------------------------P---------------------M---------------------PVPTipt- 211 house mouse
Q63379       200 KRE-------------------------S---------------------AsvpaaptsapatsavvtsvsvPAVApvaa 233 Norway rat
P18444       204 KRE-------------------------A---------------------A-----------------------VPsgge 214 chicken
AAA36371     191 KRE-------------------------P---------------------Apv-----------------paAPASapaa 207 human
NP_068609    199 KRE-------------------------S---------------------M---------------------PVATipa- 210 Norway rat
XP_005319419 195 KQNpapvrvapapapanapavgsavaraA---------------------Apa-----------------saAVAAppg- 235 thirteen-lined ...
EFB21123     193 -HL-------------------------S---------------------Vaa-----------------slGVNSgkv- 207 giant panda
XP_008115524 215 REM-------------------------KrelgttiapsctaggeagitgAla-----------------paAPAQrnsn 252 green anole
XP_006634423 181 ESP-------------------------K---------------------Aggt----------------laLPSSldt- 197 spotted gar
P52160       200 --------------------------SSSSGSDSedeeee-------------------deeeeeEEEEEEeeEEEEEID 234 zebrafish
Q9Z304       212 -----------------------stgSAISLGDHqglsssl-----------------edflsnsGSVEEGg----EEIY 247 house mouse
Q63379       234 p--------------------argsgRPANSGEHkalstsg-----------------edtlsdsDDEDDEeeDEEEEID 276 Norway rat
P18444       215 t--------------------prggrRPGPAGESrassssg-----------------ddtlsdsDDEDEEeeDDEEEID 257 chicken
AAA36371     208 gpavasgagiaapagapgvapprpggRQTSGGDHkalstsg-----------------edtlsdsDDEDDEeeDEEEEID 270 human
NP_068609    211 -----------------------sagAAISLGDHqglsssl-----------------edflsnsGYVEEGg----EEIY 246 Norway rat
XP_005319419 236 -----------------------lsnRPPNSGDHkvlstsg-----------------edalsdeVDEEEDeeEEIDV-- 273 thirteen-lined ...
EFB21123     208 -----------------------gwrKLGGSVEVrwvrfrgrnllarrwvvpvcltkrmtpvlflDDEDDEeeDEEEEID 264 giant panda
XP_008115524 253 s--------------------rhpgaANDCRANNnncsssg-----------------ddtlsdsDEEEEEddEEE--ID 293 green anole
XP_006634423 198 -----------------------ppgTSSSSGSSssgsdse-----------------dneeddeEID------------ 225 spotted gar
P52160       235 VVTVEKRQ---KrHE-------------TDASESR-YPSPLVLKRCHVSTHQHNYAAH--PSTRHDQ-PAVKRLRLEAsn 294 zebrafish
Q9Z304       248 VVMLEETQf---sKTvsrlpt-aahqenAALSPGCaQSSELILKRYDLIQEQHNYAAPplPYVDREDaRPQKKPRSHT-- 321 house mouse
Q63379       277 VVTVEKRRsssNnKAvttfti-tvrpktSALGLGRaQPGELILKRCVPIHQQHNYAAPs-PYVESEDaPPQKKIKSEAs- 353 Norway rat
P18444       258 VVTVEKRRsssN-KAvttlti-tvrpknTTFPSVRtQQNELILKRCAPIHQQHNYAAPs-PYMESEDvPPQKKLKAEV-- 332 chicken
AAA36371     271 VVTVEKRRsssNtKAvttfti-tvrpknAALGPGRaQSSELILKRCLPIHQQHNYAAPs-PYVESEDaPPQKKIKSEAs- 347 human
NP_068609    247 VVMLGETQ---FsKTvtklpt-aahsenAALTPECaQSGELILKRSDLIQEQHNYAAPplPYA--EDaRPLKKPRSQDp- 319 Norway rat
XP_005319419 274 -VTVEKs----CkTGgntftl-tvspknTALGLKReQSRELILQRSVPIYQQHNYAAPs-PYVESEDaPPQKKIKREVs- 345 thirteen-lined ...
EFB21123     265 VVTVEKRRsssHsKAvttfti-tvrpknAALGPGRaQSGELILKRCVPIHQQHNYAAPs-PYVESEDvPPQKKIKSEAs- 341 giant panda
XP_008115524 294 VVTVEKRRsssY-KSvstltiavrpknaTSFASGRtQPSEVILKRCAPIHQQHNYAAPs-PYIENEEvPPQKKLKSEAs- 370 green anole
XP_006634423 226 VVTVEKRHs-iKrSEs-----------sESGVSHRpHHSPLVLKRCHVPIHQHNYAAP--PSTRHEQ-PAVKRIKLETs- 289 spotted gar
P52160       295 nhSinssssnRHVKQ-----RKCASP 315 zebrafish
Q9Z304       322 --S-------LALKCvfrpkaprlgs 338 house mouse
Q63379       354 --P-------RPLKSvvppkAKSLSP 370 Norway rat
P18444       333 --P-------RPVKPmiqpkSKSSSP 349 chicken
AAA36371     348 --P-------RPLKSvippkAKSLSP 364 human
NP_068609    320 --L-------GPLKCvlrpkaprlrs 336 Norway rat
XP_005319419 346 --P-------RPLKSvihpkGKSFSP 362 thirteen-lined ground squirrel
EFB21123     342 --P-------RPLKSvippkAKSLSP 358 giant panda
XP_008115524 371 ----------RPVKPvaqpkLKSSSP 386 green anole
XP_006634423 290 --T-------RVLKQis-nnRKCTSP 305 spotted gar
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap