4OR2


Conserved Protein Domain Family
7tm_3
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pfam00003: 7tm_3 (this model, PSSM-Id:278433 is obsolete and has been replaced by 459626)
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7 transmembrane sweet-taste receptor of 3 GCPR
This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.
Links
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Statistics
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PSSM-Id: 278433
Aligned: 736 rows
Threshold Bit Score: 37.4993
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4OR2_A        133 ILVTlf---vtLI---FVLY--RDTPVVKS-SSRELCYII-------LAG-IFL----GY---VCp-FTl-----iAkpT 182 
ETO29040       63 LILLfqifailSV------H----NSVVMKeCAWKLCILY-------IVGgMCI---------VG--SLfv---elAt-S 110  Reticulomyxa ...
XP_002181352  299 viigicstiafLMllfVLYH--LNHTVIRLaQGPFLAALVvtclvniIFTfTALptrsIF-------------------- 356  Phaeodactylum...
KJE89762      695 ilgIfg---clIV---VHRC--NDHKIILI-AGETWCQLL-------GLA-SAL----CF---LQ--LFfr---lqNrpS 745  Capsaspora ow...
XP_011270271 1116 LFQIvg----vVV---IRLY--RDHKVVQV-AGEEWCYML-------AFS-SFM----CL---LQ--IFlh---laPr-S 1164 Capsaspora ow...
XP_002184039  231 vaisiaslailYLlveTIRH--RNNQVLQLsQAPF--LIV-------FLGaALVttvaTFllePR--------------N 285  Phaeodactylum...
XP_011403313 1021 VIVTii---liCL---LYM---RSKPQIKA-SSLLFSLIM-------FIGcYLI----CAtciVR--ITyaafpsseiiF 1077 Amphimedon qu...
XP_004998743  899 LTITia---vaVL---FIRW--RNHVVVKG-TSLVFCLLI-------LLG-IAIglctVFvlvGEl-------------S 948  Salpingoeca r...
XP_001745374  100 qAMAva---cgLY---LIRH--RAHPIVRG-TSLTFCLLI-------LFG-ILIglsaVWaliGEp-------------S 149  Monosiga brev...
XP_002110370  591 ifVSlt---ltTC---FLVHrrRKNILITE-SSYLLNMLL-------LIG-LLS----NY---VLpiLLli------piT 642  Trichoplax ad...

4OR2_A        183 TTSCYLQR---LLVGLS--S--AMC--------Y-SALV------TKtnriarilagskkkictrkprfmsawaqviias 240 
ETO29040      111 LSSCYAKL---FLRHCG--F--VLS--------L-GILF------GKtwrlwsvfnsalhlknfrmtvrknntkeyvcvc 168  Reticulomyxa ...
XP_002181352  357 ---CTLRQpmvILPSTL--MacILVgrmwrvytTlSTALgfgggrMKsindtnsedslskaivrllgllasvafccssrp 431  Phaeodactylum...
KJE89762      746 DALCGVIL---WSGHLA--Y--VLG--------L-STIA------SKlafskprsfstarnfelrvntvdmirivggsvl 803  Capsaspora ow...
XP_011270271 1165 DVVCGFIV---WDEHVC--F--ILA--------F-SLIA------VKlrtghslsegtgsrnlelkidphklffhcaial 1222 Capsaspora ow...
XP_002184039  286 DLFCR-AStpiILIGVQliF--AIA--------I-GRLWrihavisplllstlrgrshphqmegsrvngftrkvltcfth 353  Phaeodactylum...
XP_011403313 1078 EILCNVQS---VFFFNG--F--SLV--------F-VTLF------IRllrikkifgnksltkylgccwtnkamtlvvivi 1135 Amphimedon qu...
XP_004998743  949 DTRCTLYA---WLNAMS--F--AFI--------M-SNLL------VKtwriykiffsslseqqqldlsetrmivrgltyv 1006 Salpingoeca r...
XP_001745374  150 RSKCTLFH---FMEGIY--F--AFI--------M-ANLL------VKtwriykiffftfdvdkvllrycsplaersnfra 207  Monosiga brev...
XP_002110370  643 PLICTL-----SFIAFS--FctTLV--------L-LVLL------MKianlnriqderspgentssiisniviqlavlil 700  Trichoplax ad...

4OR2_A        241 ilisvqlt---------------------------------lvvtliimeppmpilsypsikevylicntsnlgvvaplg 287 
ETO29040      169 vcvcgdyqicil-------------------------vwgcfgvylgirpysfrtvvydryiyktcysesfpyvesviyv 223  Reticulomyxa ...
XP_002181352  432 dssgrntlrrtvsarettsli-------vmlflpqlllqvvslfvysadietqfelsgdsarevcdgenrgrwvsliglc 504  Phaeodactylum...
KJE89762      804 tcltll------------------------------------aiwtavypstaeiayitantvtfecafghaafswtmya 847  Capsaspora ow...
XP_011270271 1223 gisgfiv-----------------------------------aiwqivsppkaslrsvsstelqyecatetvgflyalya 1267 Capsaspora ow...
XP_002184039  354 cvscfggrtapkslrkkvsslqlslvvcafvlpqiilqmlsvtlqpmekvyefnaersngravcqigvdvaqsfarygfl 433  Phaeodactylum...
XP_011403313 1136 tiipnlmlvgw--------------------------igfdrlkretvnvtvdveplvyneeyfmctsqlmylwyamvft 1189 Amphimedon qu...
XP_004998743 1007 avqaivlg---------------------------------vvtllypirtevdliendpfaerrlvcgdglevsittll 1053 Salpingoeca r...
XP_001745374  208 lprslsegrmisralla---------------iffeaciiglfaliypigtqiddveadefgkrrllcqdgievkivtll 272  Monosiga brev...
XP_002110370  701 t-----------------------------------------------lmflgiddvtskkvvylycktnnnaiavyaya 733  Trichoplax ad...

4OR2_A        288 yNGLLIMSCTYYAFKT-RNV--------Pa---NFNEAKYIAF-TMYTTCIIWLAFVPIYfgs-------nykIIT---- 343 
ETO29040      224 cYGLAFLYIGRLAFNL-RRVtkewhlrsKgtipKYNDNKWVVIiSYNVLLMVTLLIIANHl-----------sFADpsnh 291  Reticulomyxa ...
XP_002181352  505 yTAGMHILAVFIAWVA-REL--------Ps---AFNEKDQIFSsAIVCTIITFLCITMLEiaddpatp------pdievf 566  Phaeodactylum...
KJE89762      848 lEICLLLACSFLSLRL-RSI--------Mt---LYDDGRYLLA-ALRSTTTIAAAGWIVSvifgdq-lsvstvRAI---- 909  Capsaspora ow...
XP_011270271 1268 yEVITLIACHVLGFRI-RRA--------Tt---LFNEAKLLSW-VVWVVTVFGVGGAVLVlalssa-vsatglQVF---- 1329 Capsaspora ow...
XP_002184039  434 lFVFMLFVLLAMAYST-RNL--------Ps---LLNETHVIFD-SVVTTIILIVLGVSIVf------------VSDdvst 488  Phaeodactylum...
XP_011403313 1190 yTAFILLLIVILA-ACtRKIkh----------rDFKDTKKVNAfIFIFVLTFTITGICLWlfreinqinvghtVII---- 1254 Amphimedon qu...
XP_004998743 1054 cNLLYLGIGFSLLYKT-RQVrt----------dQFGESAFVILvLLFSGVIVPGVALTLGm------------TGRarll 1110 Salpingoeca r...
XP_001745374  273 iNLVYLGAGFSLAFKT-RTIrt----------dQFSESSFVIVmLLFSGVIVPAVALTLGm------------VGLarqy 329  Monosiga brev...
XP_002110370  734 qFGLLNILCIYRAFKA-RSV--------Pi---ACYESRYILLaSILSLGLFSFAAPAYFy-----------aTGIskfg 790  Trichoplax ad...

4OR2_A        344 -TCFAVSLSVTVAlGCMFTPKMYI 366 
ETO29040      292 fLFVSVV----QIvIIIMNTSLYI 311  Reticulomyxa filosa
XP_002181352  567 lRALLTIGCSMAVlIIVVFPKMkr 590  Phaeodactylum tricornutum CCAP 1055/1
KJE89762      910 -ESVCFLAAGALLvGYILGPKMHS 932  Capsaspora owczarzaki ATCC 30864
XP_011270271 1330 -INISFFVSGCALtFIIFLPKIYS 1352 Capsaspora owczarzaki ATCC 30864
XP_002184039  489 sPAVPYLVWVTVTiSLMLnssirt 512  Phaeodactylum tricornutum CCAP 1055/1
XP_011403313 1255 -SGLLLL--VLECqVMLFLPKIMF 1275 Amphimedon queenslandica
XP_004998743 1111 fNIISTGMTSVLAlGTIFFPKVYg 1134 Salpingoeca rosetta
XP_001745374  330 fNICAIWVTCILTlASVFGPKIFG 353  Monosiga brevicollis MX1
XP_002110370  791 lSAIGAVAFPALIfLCLFVRKIIA 814  Trichoplax adhaerens
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