2KWJ


Conserved Protein Domain Family
PHD2_d4
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cd15530: PHD2_d4 
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PHD finger 2 found in d4 gene family proteins
The family includes proteins coded by three members of the d4 gene family, DPF1 (neuro-d4), DPF2 (ubi-d4/Requiem), and DPF3 (cer-d4), which function as transcription factors and are involved in transcriptional regulation of genes by changing the condensed/decondensed state of chromatin in the nucleus. DPF2 is ubiquitously expressed and it acts as a transcription factor that may participate in developmentally programmed cell death. DPF1 and DPF3 are expressed predominantly in neural tissues, and they may be involved in the transcription regulation of neuro-specific gene clusters. The d4 family proteins show distinct domain organization with domain 2/3 in the N-terminal region, a Cys2His2 (C2H2) zinc finger or Kruppel-type zinc finger in the central part and two adjacent plant homeodomain (PHD) fingers (d4-domain) in the C-terminal part of the molecule. This model corresponds to the second PHD finger.
Links
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Statistics
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PSSM-Id: 277005
Aligned: 24 rows
Threshold Bit Score: 85.5131
Created: 6-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #           #  #    #  #              #  #
2KWJ_A        60 SCiLCGTSENDDQLLFCDDCDRGYHMYCLNPpvaePPEGSWSCHLC 105 human
NP_001071860 336 SChVCGTSDNDEQLLFCDDCDRGYHMYCLQPrmenPPEGSWICNLC 381 Ciona intestinalis
XP_003386533 357 SCsLCGKSDNDDQLLFCDDCDRGYHMYCLKPpmkeAPEGSWSCGMC 402 Amphimedon queenslandica
XP_788653    371 SCgLCGTSDNDDQLLFCDDCDRGYHMYCLNPpmqaPPEGSWICDLC 416 purple urchin
GAA39327     227 TCwLCGTSENDEQMLFCDDCDRGYHMYCLSPplsePPEGSWSCQLC 272 Clonorchis sinensis
EFX71331     449 CCsLCGNSDNDEQLLFCDDCDRGYHMYCLKPplsePPEGSWSCHLC 494 common water flea
XP_006825505 350 SChLCGTSDNDDQLLFCDDCDRGYHMYCLNPpmshPPEGSWICNLC 395 Saccoglossus kowalevskii
NP_001260707 443 YCsICGTSDNDDQLLFCDDCDRGYHMYCLSPplvtPPEGSWSCKLC 488 fruit fly
XP_002160159 317 CCcLCGTSDNDDQLLFCDDCDRGYHMYCLVPaifePPEGSWQCQLC 362 Hydra vulgaris
P58267       320 NCsLCGSAENDEQLLFCDDCDRGYHMYCISPpvaePPEGTWSCHLC 365 chicken

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