Conserved Protein Domain Family
glycerol3P_DH

?
TIGR03376: glycerol3P_DH 
glycerol-3-phosphate dehydrogenase (NAD(+))
Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.
Statistics
?
PSSM-Id: 274551
Aligned: 11 rows
Threshold Bit Score: 389.779
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q09845  26 SVGIIGSGNWGTAIAKICGENAkahpdifhPQVHMWMYeekiqhegkECNLTEVFNTTHENVKYLKGIKCPSNVFANPDI 105 Schizosaccharomyces p...
P90593  10 RGAVFGSGAFGTALACVLAKKC--------ESVSVWHM---------NANEARVVNQKHENVYFLPGAPLPANLTFTADA 72  Trypanosoma brucei br...
P21696  24 SIGVVGSGNWGTAIAKICGENArahghhfrSKVRMWVFeeeieykgeKRKLTEVFNEAHENVKYLPGIECPPNVIAVPDV 103 Schizosaccharomyces p...
O57656   6 KVCIIGSGNWGSAIAKIVGANAaqns-kfdKTVKMWVFeet----vnGRKLTEIINTEHENVKYLPGHKLPTNVLAVPDL 80  torafugu
P13706   6 NVCIVGSGNWGSAIAKIVGANAaalp-efeERVTMFVYeel----idGKKLTEIINETHENVKYLKGHKLPPNVVAVPDL 80  fruit fly
P52425  24 RVTVVGSGNWGSVAAKLIATNTlklp-sfhDEVRMWVFeet---lpsGEKLTDVINQTNENVKYLPGIKLGRNVVADPDL 99  Cuphea lanceolata
Q759G5  74 KVTVIGSGNWGTTIAKVVAENTqeypqlfeRRVDMWVFeeq----ieGRKLTEIINEQHENVKYLPGITLPENLVANPSV 149 Ashbya gossypii ATCC ...
Q7ZA43  29 RITVVGSGNWGSTIAKVVAENAkelpeefhQIVKMWVFeee----vdGRKLTEIINTDHENVKYLPDVKLPDNIVAIPDI 104 Ogataea angusta
Q4PNS1  41 KIAVVGSGNWGTTIAKIVSENAvarphlfsHFVNMWVFeek----idGTNLTEIINTRHENIKYLPGVKLPKNLIAVPDI 116 Candida tropicalis
Q9UVF4  45 KVAVVGSGNWGTTVAKIVAENCtahpelfePEVRVWVReek----vnGKNLTDIFNAEHENVRYLPKIKLPHNLIAEPDL 120 Yarrowia lipolytica C...
Q6ZYA7  36 VVSVIGSGNWGTTVAKIIAENTrenpllfeQKVRMWVYeee----feGSNLSDIINTEHVNKKYLPGIKLPDNLVAVPDL 111 Cyberlindnera jadinii
Q09845 106 RDVGSRSDILVWVLPHQFVVRICNQ----LKGCL-KKDAVAISCIKGVSVTk-dRVRLFSDIIEENT-GMYCGVLSGANI 178 Schizosaccharomyces p...
P90593  73 EECAKGAEIVLFVIPTQFLRGFLQKnshiLRNHVvSRNVPVVMCSKGIERS---SLLFPAQILEEFLpNYPIGVIAGPSF 149 Trypanosoma brucei br...
P21696 104 REVARRADILVFVVPHQFIERVCDQ----MVGLI-RPGAVGISCIKGVAVSk-eGVRLYSEVISEKL-GIYCGVLSGANV 176 Schizosaccharomyces p...
O57656  81 VEASKDADILVFVIPHQFIGKVCDT----MSGNI-KKEAIGISLIKGVDEGp-dGLKLISDVIQEKL-GITMSVLMGANI 153 torafugu
P13706  81 VEAAKNADILIFVVPHQFIPNFCKQ----LLGKI-KPNAIAISLIKGFDKAeggGIDLISHIITRHL-KIPCAVLMGANL 154 fruit fly
P52425 100 ENAVKDANMLVFVTPHQFMEGICKR----LEGKI-QEGAQALSLIKGMEVKm-eGPCMISSLISDLL-GINCCVLMGANI 172 Cuphea lanceolata
Q759G5 150 AAAAADADVLVFNIPHQFLGRIVEQ----LKGHV-KPGARAISCLKGFSVGk-dGVQLLSTYIEEHL-HIPCGALSGANL 222 Ashbya gossypii ATCC ...
Q7ZA43 105 VDACADADIIIFNIPHQFLPKILAQ----LKGKV-NPKARAISCLKGLEVTk-dGCKLLSNYITEEL-GIYCGALSGANL 177 Ogataea angusta
Q4PNS1 117 VKAVKGADLIVFNLPHQFLPRILKQ----LKGHV-PKTTRAISCLKGLEVNa-nGCKLLSTVIEEEL-GIACGALSGANL 189 Candida tropicalis
Q9UVF4 121 LKAVEGANIIVFNLPHQFLAGVCKQ----LKGHV-NPKARAISCLKGLDVTp-qGVYLLSDVIENET-GLHCGVLSGANL 193 Yarrowia lipolytica C...
Q6ZYA7 112 LEAVQYSNILIFNIPHQHLEKILSQ----LRGNI-DPRARAISCLKGLRVNl-dGVELLPDIIQDAL-GIHCGVLAGANL 184 Cyberlindnera jadinii
Q09845 179 ASEVAQEKFCETTIGYLPnss---vnpRYTPKTIQALFNRP--YFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGD 253 Schizosaccharomyces p...
P90593 150 AIEVAKGMLTNVCTAAAD---------INMARKIQRIMTTSdgSFRCWATTDVIGCEIASAMKNVLAIASGALKGLGTEN 220 Trypanosoma brucei br...
P21696 177 ANEVAREQFCETTIGFNPpn-----evDIPREQIAAVFDRP--YFSVVSVDDVAGVALGGALKNVVAMAVGFADGLEWGG 249 Schizosaccharomyces p...
O57656 154 ANEVADEKFCETTIGCKN---------KSHGPLLKELMQTI--NFRVTVVEEYDVVEICGALKNIVAVGAGFCDGLGFGD 222 torafugu
P13706 155 ANEVAEGNFCETTIGCTD---------KKYGKVLRDLFQAN--HFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGD 223 fruit fly
P52425 173 ANEIAVEKFSEATVGFREn--------RDIAEKWVQLFSTP--YFMVSAVEDVEGVELCGTLKNIVAIAAGFVDGLEMGN 242 Cuphea lanceolata
Q759G5 223 APEVAKGNWSETTVAYTLpqdfrgtgkDVDHAVLKKLFHRP--YFHVNVVDDVAGISVAGALKNVVALACGFVLGLGWGN 300 Ashbya gossypii ATCC ...
Q7ZA43 178 APEVARQKWSETTVAYRIpqdfrgegkDVDQSVIRNLFHRP--YFHVRVIDDVAGVSLSGALKNVIAMAAGFVEGLGWGD 255 Ogataea angusta
Q4PNS1 190 APEIARGNWSETTVAYRVpadyrgpgkDIDKLVLKALFHRP--YFHVNVIDDVAGVSIAGALKNVVALAVGFVEGLGWGD 267 Candida tropicalis
Q9UVF4 194 ATEIALEKYSETTVAYNRpkdf-fgegDVTNDVLKALFHRP--YFHVRCVQDVAGVSIGGALKNVVALCAGFVEGKNWGD 270 Yarrowia lipolytica C...
Q6ZYA7 185 AQEVAEQRFSETTVGYPLpady--kpgDVDHTVLYTLFHRP--YFHVHVIEDIAGISCAGALKNIIAISVGFVEGLEWGD 260 Cyberlindnera jadinii
Q09845 254 NTKSAVMRIGLLEMQKFGRMFFDCKPl--tMSEESCGIADLITTCLG--GRNHKCAVAFVKt---G--KPMHVVEQEllD 324 Schizosaccharomyces p...
P90593 221 NARAALISRGLLEIRDLTLALGGTGE----AVFGLPGLGDLLLTCSSelSRNFTVGMKLGQ----G--ISLEEIKRT--S 288 Trypanosoma brucei br...
P21696 250 NTKAAIMRRGLLEMQKFATTFFDSDPr--tMVEQSCGIADLVTSCLG--GRNNRCAEAFVKt---G--KSLETLEKEllG 320 Schizosaccharomyces p...
O57656 223 NTKAAVIRLGLMEMIAFARIFCTAGPvssaTFLESCGVADLITTCYG--GRNRKVAKAFVKt---G--KSIEELEKEmlE 295 torafugu
P13706 224 NTKAAVIRLGLMEMIRFVDVFYPGSKl--sTFFESCGVADLITTCYG--GRNRRVSEAFVTs---G--KTIEELEKEmlN 294 fruit fly
P52425 243 NTKAAIMRIGLREMKAFSKLLFPSVKd--tTFFESCGVADLITTCLG--GRNRKVAEAFAKn---GgkRSFDDLEAEmlR 315 Cuphea lanceolata
Q759G5 301 NAAAAVQRVGLSEMIKFARMFFPESKve-tFYQESAGVADLITTCAG--GRNVRIGRAMAEt---G--KSAQELEKEllN 372 Ashbya gossypii ATCC ...
Q7ZA43 256 NAKSAVMRIGLVEMIKFAHMFFEDCQst-tFTHESAGVADIITTCAG--GRNVRVGRYMAEh---K--VSGFEAEKVllN 327 Ogataea angusta
Q4PNS1 268 NAKAAVMRVGLLETIKFAKLFFNDAEid-tFTGESAGVADLITTCSG--GRNVKVGRYMAEt---G--CAAEEAEKKllN 339 Candida tropicalis
Q9UVF4 271 NAKAAIMRRGMLEMINFSKRFFPETDin-tLTVESAGVADLITSCAG--GRNFKVGRAFGKesgsG--KTIQDVEKEllN 345 Yarrowia lipolytica C...
Q6ZYA7 261 NAKAAMLRRGLLEMIKFGRKFFPGCLvs-sFTEESAGVADLFTTCTG--GRNFKLAKIMAQt---G--KSAHEVEKEilN 332 Cyberlindnera jadinii
Q09845 325 GQKLQGAATAKEVYEFLDNQNKVseFPLFTAVYRIVYEG----LPPNKLLEAI 373 Schizosaccharomyces pombe 972h-
P90593 289 KAVAEGVATAEPLERLAKKHNAD--LPICHEVYNVLYANgcakRSFKKLNSCK 339 Trypanosoma brucei brucei
P21696 321 GQLLQGAATSKDVHEFLLTKDMVkdFPLFTAVYNISYED----MDPKDLIIVL 369 Schizosaccharomyces pombe 972h-
O57656 296 GQKLQGPATAAEVYRILKHKNLIdkFPLFNAVYQICYQG----HPVSEFISCL 344 torafugu
P13706 295 GQKLQGPPTAEEVNYMLKNKGLEdkFPLFTAIHKICTNQ----LKPNDLIDCI 343 fruit fly
P52425 316 GQKLQGVSTAKEVYEVLGHRGWLelFPLFSTVHEISTGR----LPPSAIVEYS 364 Cuphea lanceolata
Q759G5 373 GQSSQGIYTTQEVHEWLQQCGKKdeFPLFEAVYKIVYEG----VPMSKLPDML 421 Ashbya gossypii ATCC 10895
Q7ZA43 328 GQSCQGLHTTREVYELLAAKNVIdeFPLFKATYQIIYEG----LPMEKLPELL 376 Ogataea angusta
Q4PNS1 340 GQSSQGIVTTKEVHEFLTNVNKLeeFPLFEATYQITFGS----ESIENLPNLL 388 Candida tropicalis
Q9UVF4 346 GQSAQGVITCNEVHELLKNKNMQkdFPLFESTWGIIHGE----LKIDDLPEIL 394 Yarrowia lipolytica CLIB122
Q6ZYA7 333 GQSAQGLITAKEIHELIKNKGCEeeFPLFETTYQILFHG----VRIGILPYML 381 Cyberlindnera jadinii
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap