CDD Conserved Protein Domain Family: RRM2

cd12481: RRM2_U2B

RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")

This subgroup corresponds to the RRM1 of U2B" (also termed U2 snRNP B"), a unique protein that comprises the U2 snRNP. It was initially identified to bind to stem-loop IV (SLIV) at the 3' end of U2 snRNA. Additional research indicates U2B" binds to U1 snRNA stem-loop II (SLII) as well and shows no preference for SLIV or SLII on the basis of binding affinity. U2B" does not require an auxiliary protein for binding to RNA and its nuclear transport is independent of U2 snRNA binding. U2B" contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). It also contains a nuclear localization signal (NLS) in the central domain. However, nuclear import of U2B'' does not depend on this NLS. The N-terminal RRM is sufficient to direct U2B" to the nucleus.

P08579 146 DYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK 225 human NP_001088194 144 DNPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNETEAGSARDALQGFKITPSNAMKITFAKK 223 African clawed ... AAH59527 150 DNPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGKHDISFVEFESEAQAGVAKDALQGFRITATCAMKITYAKK 229 zebrafish XP_419331 147 DNPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENECQAGAARDALQGFKITPSHAMKITYAKK 226 chicken XP_005996928 150 DNPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENEGQAGAARDALQGFRITPSHAMKITYAKK 229 coelacanth AFM90812 147 DNPPNYILFLTNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENEGQAGAARDALQGFRITPSHAMKITYAKK 226 elephant shark

Conserved Protein Domain FamilyRRM2_U2B

Conserved Protein Domain Family
RRM2_U2B