Conserved Protein Domain Family
NDPk5
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cd04418: NDPk5 
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).
Links
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Statistics
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PSSM-Id: 239880
Aligned: 8 rows
Threshold Bit Score: 242.73
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active sitemultimer
Feature 1:active site [active site]
Evidence:
  • Comment:NDKs possess the active site motif N-x-x-H-[GA]-S-D.
  • Comment:His residue is phosphorylated during catalysis
  • Citation:PMID 8747457
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                       #       #                        
3914118       13 EKTLAIIKPDIVDk--EEEIQDIILRsGFTIVQRRKLrLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAI 90  human
AAH76282      18 ERTLALIKPDAIHk--TDEIEDIILQsGFTILQKRRLqLSPEQCSDFYAEHYGKLHFPHLTAFMSSGPVVALALARDQAI 95  zebrafish
AAH81235      19 ERTLAIIKPDVLHk--AEEIEDIILRsGFHIVQKRKVhLSPEQCSDFYSDQYGKMFFPSLTAYMSSGPIIAMTLARHNAI 96  African clawed ...
XP_790390     19 ERTLALIKPDAIDr--ADEIEEIILQsGFTILQKRRVhLTPEQMSDFYAEHFGKMFFPSLVAYMSSGPIIAMVLARENAI 96  purple urchin
XP_414687     13 EKTLALIKPDVVAk--EEEIEDLILRsGFMIVQKRKLqLSPEQCSIFYADQYGKMFFPNLAAYMSSGPSVAMILARHRAV 90  chicken
AAX26877      12 ERTLSIIKPDIIHy--ADKIEEFILGkGFSIIQKRHVhLTPEQASEFYAEHYGKISFPTIVSYISSGPIEVLIIARENAI 89  Schistosoma jap...
XP_001121989 125 ECTLMIIKPEALVy--REEIESRVREeGFQIFQTRWLqLTPEQVSEFYSDKYGQLNFAYLVAYMASGPIVVHVLGKKNAI 202 honey bee
NP_173184     33 ERTLAMIKPDGVSgnyTEEIKTIVVEaGFNIVKEMLTqLDKETASAFYEEHSSRSFFPHLVTYMTSGPVLVMVLEKRNAV 112 thale cress

Feature 1           #     #             #           #  # ##       #      
3914118       91 SYWLELLGPNNSLVAKETHPDSLRAIYGtdd--lrNALHGSNdfAAAEREIRFMFP 144 human
AAH76282      96 ATWKAIMGPVSSIKARETHPDCLRARFGtcd--lrNAVHGSEtfSAAEREIRFMFP 149 zebrafish
AAH81235      97 SHWKELIGPANSLKAKETQPDSLRAIYGtdd--lrNALHGSYcfTSAEREIRFMFP 150 African clawed frog
XP_790390     97 GYWRELCGPTNSMKARETHPDSIRAMYGidd--qqNAVHGSDgyHNSEREIRFMFP 150 purple urchin
XP_414687     91 SYWKELLGPSNSIKARMTHPHSLRAIYGtdd--lrNGLHGSLstSSAEREIRFMFP 144 chicken
AAX26877      90 SIWRELLGPQNVLKAKVIAPESLRAVYGtdd--qqNGLHGSDsfTSAEREIRFFFP 143 Schistosoma japonicum
XP_001121989 203 HEWKLLMGPTKVAEARLYYPDSIRARYGrrgddfkNAVHGSDtrECAEKEIHFFFP 258 honey bee
NP_173184    113 SDWRDLIGPTDAEKAKISHPHSIRALCGkns--qkNCVHGSDstSSAEREIKFFFK 166 thale cress

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