1LB6,1LB5


Conserved Protein Domain Family
MATH_TRAF6
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cd03776: MATH_TRAF6 
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Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses. TRAF6 is the most divergent in its TRAF domain among the mammalian TRAFs. In addition to mediating TNFR family signaling, it is also an essential signaling molecule of the interleukin-1/Toll-like receptor superfamily. Whereas other TRAF molecules display similar and overlapping TNFR-binding specificities, TRAF6 binds completely different sites on receptors such as CD40 and RANK. TRAF6 serves as a molecular bridge between innate and adaptive immunity and plays a central role in osteoimmunology. DTRAF2, as an activator of nuclear factor-kappaB, plays a pivotal role in Drosophila development and innate immunity. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors.
Links
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Statistics
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PSSM-Id: 239745
Aligned: 12 rows
Threshold Bit Score: 233.368
Created: 15-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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TNFR bindingtrimer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:TNFR binding site
Evidence:
  • Comment:TNFR = Tumor Necrosis Factor Receptor
  • Comment:Based on the binding of TRAF6 to peptides from CD40 and RANK, two members of the TNFR superfamily.
  • Structure:1LB6; Human TRAF6 binds CD40 peptide; contacts calculated at 3.5A
    - View structure with Cn3D
  • Structure:1LB5; Human TRAF6 binds RANK peptide; contacts calculated at 3.5A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #                 #                    
1LB6_A      5 GIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPtaqrCANYISLFVHTMQGEYDSHLPWPFQGTI 84  human
1LB5_A      5 GIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPtaqrCANYISLFVHTMQGEYDSHLPWPFQGTI 84  Homo sapiens
AAD34345  318 GTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLTFSRG----KPHVLSLHVHLMQSENDYHLDWPFKGRI 393 fruit fly
NP_956115 375 GIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPsaprCSNFISLFVHTMQGEFDSQLSWPLQGTI 454 zebrafish
AAH75143  385 GVFIWKIKGFSGLQKTQEEEKPVVIHSPGFYTGKPGYKLCLRLHLQLPsaqrCANYISLFVHTMQGEYDSLLPWPLHGTI 464 African clawed frog
XP_421089 352 GIYIWKIENFSGLQKAQEEERPVVMHSPGFYTGKPGYKLCLRLHIQLPsaqrCANFISLFVHTMQGEYDSHLPWPFQGTI 431 chicken
EAA07925  237 GVLLWKLDDFSNKIESMVANSNCMFYSSEAYTSPHGYKFCARINVSPR----TKDSIGLHVHLMQSENDYHLEWPFKGRI 312 Anopheles gambiae ...
AAY27978  403 GLFVWKIKNYLQRRREAETGEMTVIHSPPFYSNFYGYKLCMRCNLNGVdf-sVGRHLSVFIHFMQGEWDDILSWPFRGKI 481 Euprymna scolopes
XP_624207 219 GVYIWRLHSFHEKLESMMNDSLKMFYSPGFYTSPNGYKICARINVSSK----DPEFLSLLLHIMKSENDDGLDWPFNGTM 294 honey bee
XP_789994 502 GIFVWRLRKYSELRVSAERGEAMVRHSEGFYTGSCGYRLCVRVNINKSet-rKVLYISLFVHFMQGKYDSSLEWPFRGSI 580 purple urchin
XP_972955 253 GCYLWYFNDFKNKINAMRNDSRIMHYSPGFYTAANGYRLCIRLNLSPK----DPNYIAILIHVMKTEHDNALDWPFSGRL 328 red flour beetle
BAE93300  423 GLYYWKIKDYAQLRRAACLGEMPVLHSPGFYTSPQGYRMCIRANLDGVes-aQGTHLSLFVHLMKGDFDDVLPWPFCGSI 501 Ciona intestinalis

Feature 1                                ###         #####                             
1LB6_A     85 RLTILDQsea--pvrQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRqr-tFIKDDTLLVRCEVS 154 human
1LB5_A     85 RLTILDQsea--pvrQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRqr-tFIKDDTLLVRCEVS 154 Homo sapiens
AAD34345  394 KLCMVHPad----atLSQHDTIMTKPEILAFHKPREAISTRGFGFLEYANISNIIql-gFCADDRLLIKIEIN 461 fruit fly
NP_956115 455 RLAVLDQve-----gQHHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHLQALRqr-gFVKEDVLLVRCEVT 521 zebrafish
AAH75143  465 RLSILDQseg--aiiQDQEEVMDTKPDLLAFQRPTTQRNPKGFGYVTFMHLNTLKqr-qYVKNDTLFVRCAVN 534 African clawed frog
XP_421089 432 RLSILDQseg--perQNHEEVMEAKPELLAFQRPTIHRNPKGFGYVTFMHLQTLKqr-tFVKDDTLLVRCEVL 501 chicken
EAA07925  313 KITLLNVrs----peLSQHDTIMSKPEILAFHRPNQDISPRGFGFLEFAKIKDILa--kFADNNTVVIKIQMN 379 Anopheles gambiae str. PEST
AAY27978  482 VLSVLDQnpva-dqrQHAVETLVSKPMLAAFQRPTTHRNHKGFGYMEYVPLDVLDns-tYVVNDTLILKAQVF 552 Euprymna scolopes
XP_624207 295 YFVLVHPln----seRDIREITSSRPDLEAFRKPICELNKRSFGYTEFVRIRDLLd---FLQNDCLTFRIEVC 360 honey bee
XP_789994 581 TLSLVDQnidpelkqKNITERLVAKSNLDAFKKPKTARNHKGFGYMEFASIESLEkeglFIKDNTILIKVEVH 653 purple urchin
XP_972955 329 TITLVHPlq----pfHNIKETMMTRPELDAFKKPVQDMNPKGFGYTEFALIEELFsq-gYVENNHLLIKVQAQ 396 red flour beetle
BAE93300  502 TLTVINQkelp-sqrAHVSEMLESRANLMAFQRPITERNQKGYGYIDFLPLNLIEte-gFIKSDTLVIKAQVH 572 Ciona intestinalis

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