Conserved Protein Domain Family
NDUO42
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cd02030: NDUO42 
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.
Links
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Statistics
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PSSM-Id: 238988
Aligned: 20 rows
Threshold Bit Score: 329.317
Created: 21-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O95299     59 VITVDGNICTGKGKLAKEIaeklgFKHFPEagiHYPDSTTGDGkpla------tdyNGNCSLEKFYDdprsndgnSYRLQ 132 human
AAH68897   55 IITVDGNLASGKGQLAKNLadrlgMRYFPEadeHYLDKTTGDGsilp------skfNGSCSLEKFYDdpkcpdgnSYRLQ 128 African clawed frog
AAH84366   55 IITVDGNLASGKGQIAKKLadrlgMRYFPEadeHYLDKTTGDGsilp------skfSGNCSLDKFYDdpkcpdgnSYRLQ 128 Xenopus laevis
CAG32388   65 IFTVDGNLSSGKGKLAQHIadklgMKYFPEadiHYQDRIAGDGtlld------erfNGFCNLERFYNdpkcpdghSYRLQ 138 Gallus gallus
AAH71334   59 IISIDGNLASGKGVLAQELaeklgMLYMPEpdtHYVDKMTKEKvpld------qafNGNCSLEKFYLepkasdgnSYRLQ 132 zebrafish
NP_955872  59 IISIDGNLASGKGVLAQELaeklgMLYMPEpdtHYVDKMTKEKvpld------qafNGNCSLEKFYLepkasdgnSYRLQ 132 Danio rerio
AAQ17206   72 IFVIDGNLAVGKTTLGKELgeklgMKYFPEvdvHYFDRFEGDGspmd------krfSGNVSLEDYYKnpsdpdghSIRFQ 145 Branchiostoma belc...
AAM93654   80 VIVLEGNIGVGKTALAKSLadelgMKYFGEp-sFDQLYVDEYGfdlrsidhlapeaCRTCDIQKFYEdph--nvnVASMQ 156 black-legged tick
NP_741215  74 LIVVEGNIGSGKTTLAKQLadqlgFVHFPEf-rMDDILVDRYGndlrnyynkfparYRLPDISMFYKnps--gelSAAMQ 150 nematode
CAE70144   74 LIVIEGNIGSGKTTLAKQLadqlgFVHFPEf-rMDDILIDRYGndlrnyyskfparYRLPDISMFYKnps--gelSAAMQ 150 Caenorhabditis bri...

O95299    133 SWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTIcdy-lpPHLVIYIDVPV 211 human
AAH68897  129 YWMYSVRLMQYSDALEHLLSTGQGAVLERSPFSDFVFLEAMYKNGFIRKQCIDHYNEIKGNSIdef-lpPHLVIYVDVPA 207 African clawed frog
AAH84366  129 SWMYSVRLMQYSDALEHLLSTGQGAVLERSPFSDFVFLEAMYKNGYIRKQCIDHYNEIKGNSIdef-lpPHLVIYVDVPA 207 Xenopus laevis
CAG32388  139 AWLFGNRILQYSDALEHLLTTGQGVVLERSPYSDFVFLDAMFKQGYIHKRCVDHYKEIKGISIcef-lpPHLVIYLDVPV 217 Gallus gallus
AAH71334  133 AWMYLMRLLQYSDAVEHLLTTGQGVILERSPFSDVVFLEAMFKEGYIRKQCVNHYNEIKGISIcef-lpPHLVIYVDSPA 211 zebrafish
NP_955872 133 AWMYLMRLLQYSDAVEHLLTTGQGVILERSPFSDVVFLEAMFKEGYIRKQCVNHYNEIKGISIcef-lpPHLVIYVDSPA 211 Danio rerio
AAQ17206  146 MVMFMMRYFQFCEAMNHLIATGQGVILDRSVHSDFVFLEAMYKERYIKKHCYDYYYMVKEEVInki-lpPHLVIYLDVPP 224 Branchiostoma belc...
AAM93654  157 MIMFQLRFERYLDALVHLLNTGEGVVLKRSPFSDFVFAETMHKFGYISKLALKAYNLMKEAGLpel-lrPHLVIYLDAPS 235 black-legged tick
NP_741215 151 DRIFNCRFDQYLNALAHILNTGQGVVLERTPHSDFVFANAMRDKNYIGHEYFKHYYFVRKNALpqlhfwPHLVVYLNTPT 230 nematode
CAE70144  151 DRIFNCRFDQYLNALAHILNTGQGVVLERTPHSDFVFANAMRDKNYIGHEYFKHYYFVRKNALpqlhfwPHLVVYLNTPT 230 Caenorhabditis bri...

O95299    212 pe-vQRRIQKKGDPHEm--kITSAYLQDIENAYKKtflpemsekCEVLQYSAREaqdskkVVEDIEYLK 277 human
AAH68897  208 ae-vHKKILEKGQTSEk--kVALPYLQSIEDTYKNsflpqisenSEILKYSGNEahdvekVVEDIEYLK 273 African clawed frog
AAH84366  208 ae-vHKKILERGHTSEk--kVALPYLQSIENTYKEsflpqisenSEILKYTGNEaqdvekVVEDIEYLK 273 Xenopus laevis
CAG32388  218 pd-vQKRLQEKGEPYEk--kVSASYLQNIEDAYKKtfipemsetSEILHYTASEaedvekVIEDIEYLK 283 Gallus gallus
AAH71334  212 ee-vQKKLKASGKPYLq--nVPLSYLKSIETAYKKtflpkiseeAEVLTYGAVEaqdvekVVEDIECLK 277 zebrafish
NP_955872 212 ee-vQKKLKASGKPYLq--nVPLSYLKSIETAYKKtflpkiseeAEVLTYGAVEaqdvekVVEDIECLK 277 Danio rerio
AAQ17206  225 ee-vQKKIEKRGIEMEk--dIPLSYLETLDDAYKNnflknyskwSEVLTYDWTNygdtelILEDINALA 290 Branchiostoma belcheri tsingt...
AAM93654  236 nvllQRIKERNIPYEVqskvLAKEYLDEIDRLYKQsylrsirdnSELLLYDWTTigefelVVDDIERIN 304 black-legged tick
NP_741215 231 nk-cLENIKRRGNTDEia-tVDERYLKTIEESYKDslre-yrnhSKILAYDWTKpgdtdaVVEDIERLD 296 nematode
CAE70144  231 sk-cLENIKRRGNTDEia-tVDERYLKTIEESYKDslre-yrnhSKILAYDWTKpgdtdaVVEDIERLD 296 Caenorhabditis briggsae
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