Conserved Protein Domain Family
metH
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PRK09490: metH 
B12-dependent methionine synthase; Provisional
Links
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Statistics
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PSSM-Id: 236539
Aligned: 293 rows
Threshold Bit Score: 2125.63
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
253997651    9 IETQLRALLAQRILILDGAMGTMIQQYKLTEADYRGERFVDFKapageRELfvKGNNELLTLTQPAIIQEIHEKYLAAGA 88  
78189649     1 -------------------MGTMIQRHKLKEEDYRGSRFADHS-----HPL--LGNNDMLVLTQPDIIYTLHCAFLEAGS 54  
15893867     1 MNSSLKNLLNNKILVLDGAMGTCIQSFNLDEGDFKGSLSCTCH-----SNQ--KGNNDVLNLTKPEIIKEIHKRYLEAGA 73  
150017939    1 MNLQIKELLEKRILVLDGAMGTCIQNYKLEEKDYRG--NLNIS-----CNQ--KGNNDILNLTNPNIIREIHEAYLESGA 71  
189347541    1 MKNTLLQLLEQRILVLDGAMGTMIQRHKLQEADYRGERFASHD-----HPL--IGNNDMLVLTQPDIIYAIHCDFLEAGS 73  
189501013    1 MKESLASLLEKRILVLDGAMGTLIQTYKLEENDYRGERFASHG-----HSL--KGNNDILVLTQPDIIHAIHCEFLEAGS 73  
193214040    1 MQRDIIKLLQERILVLDGAMGTLIQRHKLTEEDFRGERFKDHS-----HSL--KGNNDILVITQPEIIKDIHRQFLEAGS 73  
194334693    1 MRETPQSLLEKKILVLDGAMGTMIQRHKLEEKDFRSERFASHS-----HPL--KGNNDILVLTQPEIIYDIHCDFLEAGA 73  
194337470    1 MKDTLLNSLEERILVLDGAMGTMIQRHKLKEADYRGTRFANHS-----HPL--IGNNDILVLTRPDIIYALHCDFLEAGS 73  
119357894    1 MKNSLINLLETRILVLDGAMGTMIQRHKLQEEDYRGTRFASHS-----HPL--IGNNDMLVLTQPDIIHAIHCDFLDAGS 73  

253997651   89 DIIETNTFGATAVAQDDYHMAHLVYEMNVEAAKLAKAACAKYS--TpDKPRFVAGALGPTPKTASISPDVNDPAARNVNF 166 
78189649    55 DIIETNSFNANPISQADYSAVELVHELNVEACRLARRAADEFSakTpNKPRFVAGSIGPTNKTLSLSPDVNRPGYRAVTF 134 
15893867    74 DIIETNTFNATEISQKDYNMQDKIYDINFKGAKLAKEACTYYTklNpNKPRFAAGSIGPTNRTASLSPDVENPGFRNVTF 153 
150017939   72 DIIETNTFNSTSISQKDYEMEDKIYELNFEGAKLAKEAADKFTaeNpDKPRFVAGSLGPTNKTASLSPDVENPGYRNISF 151 
189347541   74 DIIETNTFNANPISQGDYNAVELVRELNLEAARLARKAADAYSakTpDKPRFVAGSIGPTNKTLSLSPDVNNPGYRAVTF 153 
189501013   74 DIIETNTFNANPVSQSDYGTENLVKHINLEAARLARKAADAYSlkDpSKPRFVAGSIGPTNKTLSLSPDVNNPGYRAVSF 153 
193214040   74 DIIETNTFSSTPISLADYEVQDLTYELNLTATKLAREVADEMTakTpDKPRFVAGSIGPTNKTLSLSPDVNNPGYRAITF 153 
194334693   74 DIIETNTFNANPVSQADYGTEDLIKELNLSAASIARRAADAYTakNpSKPRYVAGSMGPTNKTLSLSPDVNNPGYRAVTF 153 
194337470   74 DIIETNTFNANPISQADYSASDLVKELNVEAARLARRAADEYTarNpDKPRFVAGSIGPTNKTLSLSPDVNNPGFRAVTF 153 
119357894   74 DIIETNTFNANPISQADYHAEHLVRELNVEAAKLARKAADAFTarNpEKPRFVAGSIGPTNKTLSLSPDVNNPGYRAVTF 153 

253997651  167 DQLVNAYLEQTRALVEGGADILMVETIFDTLNCKAALFAIDTYFEEVGRTLPIMISGTVTDASGRILSGQTVTAFWHSVR 246 
78189649   135 REVVDNYLVQLEGLREGGVDLLLVETVFDTLNCKAALFAISEIFERTGWRVPVMVSGTVVDASGRTLSGQTTEAFWSSVC 214 
15893867   154 DELCNAYKHQIEALIDGGVDLLLIETIFDTLNARAAIFAAETVFENKKIKLPIIISGTIADKSGRILSGQTLDAFAESLK 233 
150017939  152 DELAEAYKEQVLGLIDGGVDLILIETIFDALNARAALMGAKQGFLEKGKDLPVIISGTIADKSGRILSGQTLEAFANTMV 231 
189347541  154 REVVDNYIVQLEGLMEGGVDLLLIETVFDTLNCKAALFAVEEYFNAIGRRVPVMVSGTVVDASGRTLSGQTTEAFWISIA 233 
189501013  154 KEMADNYREQLEGLIEGGVDLLLVETVFDTLNCKAAILAIEEISREKGVRLPIMISGTIVDASGRTLSGQTTEAFWISVA 233 
193214040  154 QNVVDAYTEQLKGLLDGGVDILLVETVFDTLNCKAALFAIHEFFNKTQRRVPVMVSGTVVDASGRTLSGQTTEAFWISIS 233 
194334693  154 QDVVDNYILQLDGLVEGGVDLLLVETVFDTLNCKAALYAIEEHSRKTGKNLPIMISGTVVDASGRTLSGQTTEAFWISVA 233 
194337470  154 QEVVDNYTLQLEGLMEGGVDLLLVETVFDTLNCKAALFSIEEFFNRTGVRIPVMVSGTVVDASGRTLSGQTTEAFWISIA 233 
119357894  154 RNVVDNYIMQLEGLMEGGVDLLLVETVFDTLNCKAALFAIEEFFNRIGKHIPVMVSGTVVDASGRTLSGQTTEAFWISIA 233 

253997651  247 HAKPL-TIGLNCALGATLMRPYVEELSSIADTFVCIYPNAGLPNPMSdtGFDETPDVTSSLVKEFAQSNFLNIAGGCCGT 325 
78189649   215 HLPELlSIGLNCALGSKQMRPFIEAMANVAESYVSVYPNAGLPNEFG--QYDDSPEYMATQIADFATSGFVNIVGGCCGT 292 
15893867   234 NENII-AIGLNCSFGAEELIPFIKRLSETQNRYISFHPNAGLPNSLG--EYEELPEETASIVKKLALEGHLNIVGGCCGT 310 
150017939  232 DESII-AIGLNCSFGAKDLIPFVKYLSRTQNRYISVYPNAGLPNSFG--EYDEKPEETAALIKSLAEDGCLNIVGGCCGT 308 
189347541  234 HMPDLiSVGLNCALGSKQMRPFIEALSGIAESYVSVYPNAGLPNEFG--EYDDSPAYMAAQIAGFAESGFVNIVGGCCGT 311 
189501013  234 HTPGLlSVGLNCALGAKQMRPFLEALSHVAGSLVSVYPNAGLPNEFG--EYDDSPEYMASQIADFAQSGFVNIVGGCCGT 311 
193214040  234 HMPDLmSVGLNCALGAKQMRPFVEAMSNVAQTYTSVYPNAGLPNEFG--EYDDSPEYMAAQIEDFAKSGFVNIVGGCCGT 311 
194334693  234 HTPNLlSVGLNCALGSKQMRPFVEALSGIAESYVSVYPNAGLPNEFG--EYDDSPEYMASQIADFARSGFVNIVGGCCGT 311 
194337470  234 HMPDLlSIGLNCALGSKQMRPFIEALAGIAESYVSVYPNAGLPNEFG--EYDDSPEYMAGQIAGFATSGFVNIVGGCCGT 311 
119357894  234 HMPDLlSVGLNCALGSKQMRPFIESLSGIAESYVSVYPNAGLPNEFG--EYDDSPAYMAEQIAGFATSGFVNIVGGCCGT 311 

253997651  326 TPAHINAIYNEIKDLPPRQLPALPRTLKLSGLEPFVVDDDSLFVNVGERTNVTGSKAFARLIINEQYDEALTVARQQVEN 405 
78189649   293 TPDHIKAIAEAVQTISPRKRPTKKHELLLSGLEPLVVNHTTGFINIGERTNVTGSKKFARLIKEGNYDEALSIARQQVEN 372 
15893867   311 TPEHIRAISSVVKGISPRKVPNLEPKTIYSGLENIKIDKNSNFINIGERTNVAGSRKFARLIREKNYEEALTIARHQVEN 390 
150017939  309 TPDHIKAVSEAIKDISPRKIPDIETETVYCGLEALRANKENNFINIGERTNVAGSAKFARLIREKNYEEALSIAKDQVEN 388 
189347541  312 TPQHIKAIADAVSSLKPRRKPEPKHELQLSGLEPLMVNQTTGFINVGERTNVTGSRKFARLIKEGNYDEALSIARQQVES 391 
189501013  312 KPEHIRAIAETVATIEPRKKPSMPTELRLAGLEPLIVNKTTGFINIGERTNVTGSRKFARLIREEKYDEALSIARQQVEN 391 
193214040  312 TPAHIKAIAETVKTLPPRKRPEPHHILQLSGLEPLAVDKTTGFINIGERTNVTGSRKFARLIKEGNYDAALSIARQQVES 391 
194334693  312 TPDHIRAIARDVAAIEPRRKPKASHELQLSGLEPLLVNKTTGFINIGERTNVTGSRKFARLIKEENYDEALSVAREQVEN 391 
194337470  312 TPQHIKAIAEAVEKLQPRRRPVKKHELQLSGLEPLFVNRTTGFINVGERTNVTGSKKFSRLIKESKYDEALSIARQQVES 391 
119357894  312 TPQHIEAIAEAVQALEPRKRPHREHELKLSGLEPLVVNSTTGFINVGERTNVTGSKKFARLVKEGNYDEALSIARQQVES 391 

253997651  406 GAQVIDINMDEGMLDAIKAMTHFLNLVASEPDIARVPIMIDSSKWSVIEAGLKCVQGKAVVNSISMKEGEEEFIRQAQLC 485 
78189649   373 GAQVIDVNVDEGMLDSEKVMKEFLNLIASEPEISRVPIMIDSSKWSVIESGLQCVQGKGIVNSISLKEGDELFRERARKI 452 
15893867   391 GAQIIDINFDDALLDARSEMETFLRLIASEPEISKVPVMIDSSNFEVLKVGLKSIQGKAIVNSISLKVGEEKFIEEAKFI 470 
150017939  389 GAQIVDINFDDALLDAKEEMDKFLKLLASEPEISKVPVMIDSSKFEVLVTGLKAIQGKPIVNSISLKVGEEEFKRQASII 468 
189347541  392 GAQVIDVNVDEGMLDSEKVMKEFLNLIASEPEISRVPVMIDSSRWSVIEEGLQCVQGKSIVNSISLKEGEDPFRERALKI 471 
189501013  392 GAQVIDINVDEGMLDSEKVMRDFVNMIGSEPEIARVPLMIDSSKWSVIESGLCCVQGKSIVNSISLKEGEDLFRERAKKV 471 
193214040  392 GAQVIDVNVDEGMLDSEKVMAEFLNLIASEPEIARVPIMIDSSKWSVIEAGLRCTQGKCIVNSISLKEGEAIFKERAEKI 471 
194334693  392 GAQVIDINVDEGMLDSEKVMHEFINLIASEPEISKVPLMIDSSKWSVIESGLRCSQGKCIVNSISLKEGEELFKQRAKKI 471 
194337470  392 GAQVIDVNVDEGMLDSEVVMREFLNLIGSEPEISRVPVMIDSSKWSVIESGLRCVQGKSIVNSISLKEGEALFIERARKV 471 
119357894  392 GAQVIDVNVDEGMLDSEKVMREFLNLIGSEPEISRVPIMIDSSKWSVIENGLQCVQGKSIVNSISLKEGEDLFRERAQKV 471 

253997651  486 KRYGAAAIVMAFDEKGQADTFERKIEICKRAYDLLVEKLDFPPEDIIFDPNIFAIATGIEEHNNYAVDFINATHWIKQHL 565 
78189649   453 LRYGAATVVMAFDEQGQADNLQRRIEICQRAYNILVNEVGFPPEDIIFDPNVLTVATGIEEHNNYAVDFIESVRWIKENL 532 
15893867   471 KNFGAGVVVMAFDEEGQAATYERKIEICKRAYTILTEKVEFPPENIIFDPNILSIATGIEEHDNYAVNYIKAVKWIKENL 550 
150017939  469 RDFGAAVVVMAFDENGQADSYEKKISICKRAYDILVNEVNFPPQNIVFDPNILTIATGIEEHNNYAVDFINATKWIKENL 548 
189347541  472 LQYGAAAVVMAFDEQGQADSLERRKEICGRAYDILTREVGFPPEDIIFDPNVLTVATGIDEHNNYALDFIESVRWIRENL 551 
189501013  472 MIYGAAAVVMAFDEKGQADSLERRIEICERAYRILVDEVGFHPENIIFDPNVLTVATGIEEHDNYAVDFIESVRWIKENL 551 
193214040  472 LEYGAAAVVMAFDEKGQADSYERRVEICSRAYKILTEEVGFPPEDIIFDPNVLTVATGIEEHNNYAVDFINSVRWIKQNL 551 
194334693  472 LQYGAATVVMAFDEKGQADSLERRIEICSRAYSILCEEVGFPPEDIIFDPNVLTVATGIEEHDNYAVDFIESVRWIKQNL 551 
194337470  472 LQYGAATVVMAFDEEGQADSYQRRIEICKRAYDILTQQVGFPPEDIIFDPNVLTVATGIDEHNNYAVDFIETVRWIKENL 551 
119357894  472 LQYGAAAIVMAFDEQGQADSYARRIEICKRAYDLLTMEVGFPPEDIIFDPNVLTVATGIDEHNNYAVDFIETVRWIKENL 551 

253997651  566 PYAKISGGVSNVSFSFRGNDPAREAIHTVFLYHAIKAGMTMGIVNAGMMGVYDDLAPELKERVEDVVLNRvVDPnnplaA 645 
78189649   533 PHAKVSGGISNVSFSFRGNEPVREAMHAAFLYHAIRAGLDMGIVNAGQLAIYEDIEPELLVRVEDVLLNR-RAD-----A 606 
15893867   551 PYAKVSGGVSNLSFSFRGNDAIRRAMHSVFLYHAINAGMDMGIVNPAMIDLYDDIDKDLLEKVENVVLNK-SSN-----A 624 
150017939  549 PYAKVSGGVSNLSFAFRGNNVIREAMHSVFLYHAIKNGMDMGIVNPGMIQIYDEIDKGLLEKVEAVIFNK-SEN-----A 622 
189347541  552 PYAKVSGGISNVSFSFRGNEPVREAMHAAFLYHAIRAGLDMGIVNAGQLAIYEDIEPTLLELVEDVLFNR-RPD-----A 625 
189501013  552 PHARVSGGISNVSFSFRGNNPVREAMHAAFLFHAIHAGLDMGIVNAGQLAVYDDIEPELLERVEDVLLNR-RKD-----A 625 
193214040  552 PHAKISGGISNISFSFRGNEPVREAMHAAFLYHAIREGLDMGIVNAGQLAIYEDIDKDLLERVEDVLLNR-RED-----A 625 
194334693  552 PFAKISGGISNVSFSFRGNNPVREAMHAAFLYHAIHAGLDMGIVNAGQLAIYQDIEPELLERVEDVLLNR-RKD-----A 625 
194337470  552 PHAKVSGGISNVSFSFRGNETVREAMHAAFLYHAIQAGLDMGIVNAGQLAIYEDIEPELLLRVEDVLLNR-RAD-----A 625 
119357894  552 PYAKVSGGISNVSFSFRGNEPVREAMHAAFLYHAIRAGLDMGIVNAGQLAIYEDIDPELLERVEDVLLNR-RPD-----A 625 

253997651  646 TERMIEIASTLV--AGGKKEAATLEWRGTPenpvpVEKRLSHAMVHGITEFIVDDTEEARQKVAAaggrPIHVIEGPLMD 723 
78189649   607 TERLVSFAETIAt-GGEKVEAKAAEWRNLP-----VAERLRHALIKGIVEHIEEDTEEARQLYPS----PLQVIEGPLMD 676 
15893867   625 SESLLEFAQTYKk-TTETLEKHEDEWRQKS-----PSERLSYALVKGNVEFIEEDIEEARKEYTN----ALEIIEVPLMN 694 
150017939  623 ADELLEFAANFNk-VDNKLEENKEAWRNEN-----VKERLKTALVKGIDKYIKEDVEEVRAEYSK----SLEVIEGPLMD 692 
189347541  626 TERLVSHAETIRe-GGEKIEAKAAEWRNAP-----VEERLRHALVKGIVEYIDVDTEEARQLYPS----PLQVIEGPLMD 695 
189501013  626 TERLVEFAETIKd-DGQKAEAKQAEWRNGT-----VEERLQHALVKGIVDYIDSDTEEARQAYAS----PLDIIEGPLMG 695 
193214040  626 TERLVDFAETIKs-DGSKSEAKKAEWRNLP-----VEERLKHALIKGIVEHIDEDTEEARQKYPR----PLHVIEGPLMD 695 
194334693  626 TERLVDYAGSMIseDTTKNSPKKAEWRNES-----VEKRLEHALIKGIVDFINEDIEEARLKYAS----PLKVIEGPLMH 696 
194337470  626 TERLVSFAETIQs-GGEKIEAKAAEWRSLP-----VEERLRHALIKGIVEHIEEDTEEARQLYPS----PLQVIEGPLMN 695 
119357894  626 TERLVSFAETIQg-DGEKTEAKAAEWRSFP-----VEERLRHALIKGIVEYIEEDTEEARLLYPS----PLQVIEGPLMN 695 

253997651  724 GMNVVGDLFGQGKMFLPQVVKSARVMKSAVAHLIPFIEAe-KAadE--ARtgiVAKPKGKMVIATVKGDVHDIGKNIVSV 800 
78189649   677 GMNAIGDLFAVGKMFLPQVVKSARVMKRSVAHLIPFIEA--EK--AknK----DTSAQAKVLLATVKGDVHDIGKNIVAV 748 
15893867   695 GMKKVGKLFGEGKMFLPQVVKSARVMKKAVECLLPYINE--EKsk-------nHNKSAGKVVFATVKGDVHDIGKNIVSV 765 
150017939  693 GMNEVGKLFGDGKMFLPQVVKSARVMKKAVEVLRPYLEE--EK--S--SS---GSISAGKVVFATVKGDVHDIGKNIVSV 763 
189347541  696 GMNTIGDLFAEGKMFLPQVVKSARVMKRSVAWLIPYIEE--EK--AqqK----NSKPAARVLLATVKGDVHDIGKNIVSV 767 
189501013  696 GMNVIGDLFAEGKMFLPQVVKSARVMKKAVAWLIPYIEE--EK--AknK----DTRPVAKVLLATVKGDVHDIGKNIVSV 767 
193214040  696 GMNTIGDLFAEGKMFLPQVVKSARVMKKSVAYLIPFIEE--EK--AqcE----DSKPAAKVLLATVKGDVHDIGKNIVGV 767 
194334693  697 GMDVIGDLFAAGKMFLPQVVKSARVMKKGVAYLIPFIEE--EK--RkgN----DSSAAAKVLLATVKGDVHDIGKNIVSV 768 
194337470  696 GMNAIGDLFAEGKMFLPQVVKSARVMKRSVAVLLPYIAAekALnkD--TR------AAAKVLLATVKGDVHDIGKNIVAV 767 
119357894  696 GMNAIGDLFAVGKMFLPQVVKSARVMKRSVACLIPWIEK--EK--AanK----DTRAAAKVLLATVKGDVHDIGKNIVAV 767 

253997651  801 VLQCNNFEVVNMGVMVPASEILAMAKAENADIIGLSGLITPSLEEMAHVAREMQRDPYFseqkMPLLIGGATTSRAHTAV 880 
78189649   749 VLACNNYEVIDIGVMMPCEKILEAVEREKADLLGLSGLITPSLDEMVHVAAEMERRGMK----IPLLIGGATTSRMHTAV 824 
15893867   766 VLSCNNFEVIDLGVMVPPETILETAKRENADIIALSGLITPSLNEMAYVAEEMKRLNFD----IPLMVGGAATSKTHTAL 841 
150017939  764 VLSCNNFEVIDLGVMVPTEIILETAKKENADIIALSGLITPSLEEMSNVAEEMEKQGFK----IPLMVGGATTSKAHTAI 839 
189347541  768 VLSCNNYEVIDIGVMMPCDRILDAVEREKADILGLSGLITPSLDEMVHVAREMERLGMK----IPLLIGGATTSKMHTAV 843 
189501013  768 VLACNNFEVVDIGVMMPCENILEAAEKEKADIIGLSGLITPSLDEMVHVAKEMERKGMR----IPLLIGGATTSRVHTAV 843 
193214040  768 VLACNNFQVVDIGVMMPCEKIMEAIEKEKPDVVGLSGLITPSLDEMAHVAKEMQRAGMN----IPLLIGGATTSKVHTAV 843 
194334693  769 VLACNNYDVVDIGVMMPCEKILDAAEKEHADIIGLSGLITPSLDEMVHIAKEMERRGMT----IPLLIGGATTSKVHTAV 844 
194337470  768 VLACNNYDVVDIGVMMPCDKILEAVEREKADLLGLSGLITPSLDEMVHVASEMERLGMT----IPLLIGGATTSRMHTAV 843 
119357894  768 VLACNNYDVVDIGVMMPCEKILEAAEREKADLIGLSGLITPSLDEMVHVAREMERLGMT----IPLLIGGATTSRIHTAV 843 

253997651  881 KIAPHYDGPIVYVADASRSVTVMQNLLTPETRGAYLAEIQADYEKARTQHANKKG-TPMLTIAEARANKADLSFaGADAP 959 
78189649   825 KIAPVYSGAVVQVLDASRSVPVVNSLLNPALSPKYIADLKNEQAGLRESHAAAQAaRNYVSLADARNNAAKVE----PVA 900 
15893867   842 KLATKYK-YVVHSTDASDAVTVAKNLMSEN-KFTFLEKLNEEYSKIRETFSTNK--IELISIQNARKNRFTIDW-NKTKI 916 
150017939  840 KIAPKYSGGVIHTTDASKAVEAAKLLLNKDKKAEYLNKIESEYETLRETF--NKVpRKFVTLDYARENNFKKEW-DKEQI 916 
189347541  844 KIAPVYSGPVVQVLDASRSVPVVSSLLNPMLCDDYLARLKADQATMRQSHESRSReKKYLSIEDARKNRPDLQW-DETTV 922 
189501013  844 KIAPNYSGPVVQVLDASRSVPAVNSLLTSSMKGAFVKKLTEEQHSLRESHAARQTsRQHRSIGESRENRAKLSW-SPETV 922 
193214040  844 KLAPHYSAPVLHVLDASRSVPVVNNLVSDEQKSDYIAKHFAEQAQMREDHEKRNAkRKFVSLEAARENALKIDW-SESEV 922 
194334693  845 KIAEHYSGPIVHVLDASRSVPAVNNLVTPSLKTNYVEKLLAGQEELRRKHKEKNAaKTYLSIAEARKNHAELSW-ND-AP 922 
194337470  844 KIAPVYSGAVVQVLDASRSVPVVNSLLNPALSPDYIAGLKAEQAGLRESHASRAAgKKYLTLQEARNNRLALQ----GSI 919 
119357894  844 KIAPVYSGPVIQVLDASRSVPVVSSLLNPALSETYIGQLKKEQAELREGHAARAAgNKYLSLPDARKNRAKLQW-DDTTV 922 

253997651  960 VKPKF-IGRREIKNADLSVIAQYIDWTPFFQTWDLAGFYPAILKDEVVGDAATKLFNEAQMMLKKII-DGRWLTANGVVA 1037
78189649   901 VQPKK-VGLTLFEDVAVAELRAYIDWTPLFMTWELHGRYPQILSDAKYGSEAQKLLNDANALLDRIE-LEKLLGVKGVVG 978 
15893867   917 TEPKF-VGIKKLQAVPINELRKYIDWTFFFTSWDMGMNYPKIMKDPKYGAEAQKLFKDANEMLDLLQ-KENLITCNGVFG 994 
150017939  917 EKPKM-LGIKKFIDFPIGKLRKYIDWSFFFIAWDMGMTYPQILEDAKYGEEAKKLLADAEKMLDKME-SENILKANAAFG 994 
189347541  923 RTPLK-TGITLFEDVTVSALRPYIDWTPFFLTWELHGRYPEIFGNAKFGSEARQLFDDANELLDTID-REKLLGLKGVAG 1000
189501013  923 TIPNH-PGITEQANVSLSELREYIDWTPFFNVWELHGKYPDIFENKHCGSEARKLFEDANSLLDRIC-EEKSLVAKGVAG 1000
193214040  923 FAPKQ-AGITKFENVSLAELRKYIDWTPFFLTWELHGKYPNIFEHEKFGEEAKKVFDDANALLDKII-TENAIQAKGVVG 1000
194334693  923 PAPPLkPGITTFDRVSLDELREYIDWTPFFRVWEIHGLWPAIKSDPHYGEEATKLYDDANRLLDTMCaDTSSLQARGVAG 1002
194337470  920 CKPLQ-PGITLFEHVTAGELRPYIDWTPFFMTWELHGRYPQILDDPKYGSEAKKLFDDANSLLDRIE-QEQLLGLKGVAG 997 
119357894  923 YNPLK-PGITLIEDATVEALRPYIDWTPLFLTWELHGRYPQIFDHKEYGNEAKKLFDDANKLLDRIE-KEKLLGLRGVAG 1000

253997651 1038 LHPANRTGdDDIEIYTDETRTNIAFTYYGMRQQTVKPvidgiARPNQCLADFIAPK--GTPDYIGLFAVTAGLGIEKHEQ 1115
78189649   979 IFPANSTG-DDIAIYTDESRTKVLTTLHTLRQQQEKAn----GEANVALADFIASAdsGVADYLGAFAVTTGLGIAKTLE 1053
15893867   995 IFPANSVN-DDIEIYTDKG----TVTINTLRQQQILK-----DSDYKALSDYIAPKgiGIKDYIGGFIVTAGIGAKEYSD 1064
150017939  995 LFEANSVG-DNIEVY----NDSEMINFNLLRQQEVKK-----DNTYMCLSDFIAPKdtGIKDYIGAFITTGGIGAKEYAD 1064
189347541 1001 IFPANSSG-DDVVIYTDDNRSSALMQVHTLRQQQEKQe----GEPNLALADFIAPEesGIRDYIGAFAVTAGLGIEKTLN 1075
189501013 1001 IFPANSVG-DDIEIYTDESRATVLTTLHTLRQQHEKNt----GSANLALADFIAPKssGRDDYIGAFTLTAGHGVKELMK 1075
193214040 1001 IFPANSVG-DDIEVYADENRSETCTVLHTLRQQNEKSs----GQSNIALADFVAPKesGLKDYVGGFAVTAGLGIEKLMK 1075
194334693 1003 IFPANSNG-DDIEVYTDEERTTLRCTLHTLRQQAEQKq----ASPNLALADFIAPKssGIKDYIGCFTLTTGHGLQEIMD 1077
194337470  998 LFPANSSG-DDIEVYSDESRTSLLAILHTLRQQQEK------GEPNLALADFIAPVgsGLEDYIGAFAVTAGLGIEKGLR 1070
119357894 1001 IFPASSNG-DDIDVFTDESRSTVLTTFHTLRQQQEKKa----GEPNLALADFIAPEksGIKDYIGCFAVTAGLGIERTLK 1075

253997651 1116 RFEAAHDDYSSIMLKALADRLAEAFAEYMHERVRVDFWGYAPN---------------------ENVTKE---------- 1164
78189649  1054 RFVAEHDDYHRILMQTVADRLAEAFAEMLHECVRREVWGYEEVcsktsscca---chaesattsQANHLE---------- 1120
15893867  1065 KLKKKCDDYGATMLKLICDRLAEAFSELLHLRVRKEYWGYSQD---------------------ENLSLE---------- 1113
150017939 1065 KLKASGDDYGATMVILLADRLAEAFAEYVHEKVRKEYWAYSPD---------------------ENLFIE---------- 1113
189347541 1076 RFSLEQDDYRRILTQALADRLAEAFAEMLHEKVRRELWGYAPA---------------------EILGSE---------- 1124
189501013 1076 RFEAEHDDYHRIMVQALADRLAEAFAEMLHQRVRKELWGYAID---------------------ENLTKK---------- 1124
193214040 1076 EFAAAHDDYHRIMTQALADRLAEAFAEMLHEKVRRELWGYATS---------------------ESLSSD---------- 1124
194334693 1078 RFAEDHDDYHRIMAQALADRLAEAFAEMLHRKVRMELWGYAPD---------------------ESLDHD---------- 1126
194337470 1071 EFSDQQDDYHRIMMQALADRLAEAFAEMLHERVRRELWGYECA---------------------EKRDGDkgcachpapq 1129
119357894 1076 QFSEEQDDYHRIMTQALADRLAEAFAEMLHEKVRKELWGYAPDrcvknnipcachpvpagktehEALGIE---------- 1145

253997651 1165 -------GLIKEQYQGIRPAPGYPACPDHTVKPDMFKLLQA-EAISMALTESFAMSPGAAVSGFYFAHPESKYFSVDKIG 1236
78189649  1121 -------ELLAGNYQGIRPAPGYPACPDHSEKAEIFTLLNAeVNTGITLTENFAMNPAASVSGLYLAHPEARYFMLGKIG 1193
15893867  1114 -------KLLKGSYRGIKPAIGYPSIPDHSEKAKLFDLLLGkTSIGVELTESYMMNPTSSVCGLYFANERAKYFNINKIG 1186
150017939 1114 -------EIFKGKYRGIRPAIGYPSLRDHSEKVKLFNLLDKeGELNVKLTESYMMSPTASTCGLYFGNKDAKYFDINKIH 1186
189347541 1125 -------ELLSEKYRGIRPAPGYPACPDHTEKAELFTLLNAeTNTGITLTETYAMNPAASVSGFYFAHPEARYFVLGKIG 1197
189501013 1125 -------QLLNEKYRGIRPAPGYPACPDHTEKPLIFNLLNSeAITGVTLTETYAMNPPASVCGLYFAHPEAKYFVLGSIG 1197
193214040 1125 -------ELIHEKYQGIRPAPGYPASPDHSEKPILFKLLGAeEATGISLTETCAMSPAASVSGLYFAHPKASYFSVGKIG 1197
194334693 1127 -------QLIGEKYRGIRPAPGYPACPDHTEKPKIFDLLNSeAATGVTLTETFAMNPQASVCGLYFAHPEAKYFILGQIG 1199
194337470 1130 cqphpihELLAEKYQGIRPAPGYPACPDHTEKAELFTLLNAeTNTGITLTETFAMKPAASVCGLYFAHPQAKYFMLGKIG 1209
119357894 1146 -------ALLAEKYQGIRPASGYPACPDHTEKAELFTLLNAeTSTGITLTETFAMNPAASVSGLYFAHPAAKYFVLGKIG 1218

253997651 1237 IDQLEDMAKRRGLTKEYLERWLAPNLS 1263
78189649  1194 KDQVEDYAQRKGINVAEAEKLLATSLN 1220
15893867  1187 KDQLEDYAVRSNKDINEIKKLLDTLL- 1212
150017939 1187 QDQFNDYAQRNGRDKGELKKLMYTIID 1213
189347541 1198 RDQVEDYALRKGMSVQETEKWLAPALN 1224
189501013 1198 KDQVEEYALRKGMSMAEAEKWLAPNLN 1224
193214040 1198 KDQAEDYAARKGMKMEEVEKWLSTALN 1224
194334693 1200 KDQVEEYAERKKMTRSEVEKWLAPNLN 1226
194337470 1210 RDQVEEYAERKGMSIKETEKWLAPALN 1236
119357894 1219 RDQVEDYAVRKGMSVEQAERWLAPALN 1245
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