134854 346 LERNWIAEKIsvDKNFDANYDlteFKEAIGNAIKFITKENLEVPFIYAYRRNyiss----rekDGFLLTEDDLWDIVSLD 421 baker's yeast 19703417 1 -----MMEKI--YKIVAEELK---IPVDKVENTIKLLDDGATIPFVARYRKE-----------ITGNLDEVQIGDILQKV 59 Fusobacterium nuc... 15672267 1 -------MEN--VKKIAELLN---IKNSQVEKVLELTAEGNTVPFIARYRKE-----------ATGSLDEVEIKKIIDED 57 Lactococcus lacti... 15927638 1 -----MDNQL--INSIIEKYQ---FSKKQIEAVLTLLEEKNTVPFIARYRKE-----------QTGGLDEVQIKQIDDEY 59 Staphylococcus au... 15900789 1 ------MDKK--YEKISQDLG---VTLKQIDTVLSLTAEGATIPFIARYRKD-----------MTGSLDEVAIKAIIDLD 58 Streptococcus pne... 19115399 197 AWIIDYLLKN--RRDIDAELYe-pFQTAVRYVVHFFIRDSLEVPFIWQHRRDyivhnnrerntITPLLSQNDLWNIFFLC 273 fission yeast 15674668 1 -----MENNN--NHNIAEALS---VSLHQIEQVLALTAQGNTIPFIARYRKE-----------VTGNLDEVVIKSIIDMD 59 Streptococcus pyo... 15639909 9 DALSVQEDEL--AERVARELH---IRTAQVTAVRSLLKEGCTVPFIARYRKE-----------AHHCLDEVLIRDCERLF 72 Treponema pallidum 13357585 1 -----MIDLI--IKTLVQKLK---IEAKYITNVLNLLADNNTIAFIARYRKH-----------LTNNMDEFQIQAIAHEY 59 Ureaplasma urealy... 16799970 2 E---QMQEKI--MKLVQKSLT---YKPAQINAVIKLMEEGNTVPFIARYRKE-----------MTGSLDEVEIRDIEETF 62 Listeria innocua
134854 422 IEFHSLVNKKDYVQRFYAELHIddpiVTEYFKNQNTAsIAELNSLQDIy--dYLEFKYANEINEMFInh--tGKTGKKHL 497 baker's yeast 19703417 60 EYLRNLEERKEEVIRLIEEQGK----LTEELRNSIIE-AKILQEVEDI----YFPYRKKKKTKADIA-----KERGLEPL 125 Fusobacterium nuc... 15672267 58 NLLTKLSERKTAVLSKIEELGK----LTDSLKAQILA-AEKLTEVEDL----YLPYKEKRRTKATIA-----KENGLFPL 123 Lactococcus lacti... 15927638 60 QYMVNLQKRKEEVIKNIEQQGL----LTEELKKDILK-QNKLQRVEDL----YRPFKQKKKTRATEA-----KRKGLEPL 125 Staphylococcus au... 15900789 59 KSLTNLNDRKEAVLAKIQEQGK----LTKELEEAILV-AEKLADVEEL----YLPYKEKRRTKATIA-----REAGLFPL 124 Streptococcus pne... 19115399 274 TKFWSLHSKKQDILKLYSDLGI----NDDLVVPFCEA-ASSLDAIDDLndyiHFTYSEQIRDRALLMgtglrRPQGSKYS 348 fission yeast 15674668 60 KSLTTLNERKATILAKIEEQGK----LTDQLRTSIEA-TEKLADLEEL----YLPYKEKRRTKATIA-----REAGLFPL 125 Streptococcus pyo... 15639909 73 HTHLARETRRLEIIRAVFKEGM----LTPTLYEHLRS-APTLAALEDL----WAPFKKKKKTRGMQA-----IEKGLEPL 138 Treponema pallidum 13357585 60 EYLTKLNKRKEVIIKNLEQKGL----LTNDLLELINN-CQRLVDLENL----YEPYASNKKTKASIA-----IEKGLEPL 125 Ureaplasma urealy... 16799970 63 EYVTKLENRKEEIIRLIDEQGK----LTDELKAAIIK-AEKHQALEDL----YRPYKQKKRTKATIA-----KEKGLEPL 128 Listeria innocua
134854 498 KNSSYEKFKASPLyqavsdigisAEDVGENISsqhqihppvdhpsskpveviesilnansgdLQVFTSNTKLAIDTVQKY 577 baker's yeast 19703417 126 AEKFYTANNLEEI----------QSLAKDFIT--------------------------------EEVRTIEDAIEGAMLI 163 Fusobacterium nuc... 15672267 124 AQLIVKN--SANL----------EEEAEKFVN--------------------------------ENFTSPQKALEGAVDI 159 Lactococcus lacti... 15927638 126 AIWMKARKHEVSI----------EEKAQQFIN--------------------------------EEVQSVEDAIKGAQDI 163 Staphylococcus au... 15900789 125 ARLILQN--IVDL----------EKEAEKFVC--------------------------------EGFATGKEALTGAVDI 160 Streptococcus pne... 19115399 349 FFEKFRKSSLYNLvk------efGMSAKDFSFnvaqgarlrfved-----ntlspeelsrtyVTNELSSPEQVLQKARRV 417 fission yeast 15674668 126 ARLILQN--AQNL----------ETAAEPFVT--------------------------------EGFASPQEALAGAVDI 161 Streptococcus pyo... 15639909 139 ARLIETQCATQAEi---------ERAAAALVApa--------------------------adSDRAVSSAQDAIAGACDI 183 Treponema pallidum 13357585 126 ALLILKNNPNSNIk----------EVAKQYLN--------------------------------EQVLSVDEAIAGACDI 163 Ureaplasma urealy... 16799970 129 ADWLMSFPSNANP----------LEEAAKYISe------------------------------EKEVTSAEDALLGAHEI 168 Listeria innocua
134854 578 YSLELSKNTKIREKVRSDFSKYYLADVVLtAKGKK----EIQKGSLYEDIKYAIN--RTPMHFrrdpdvFLKMVEAESLN 651 baker's yeast 19703417 164 IAQNISEKAEYRERIREIYLKYSIIESKAsKKAAEl--dEKKVYTDYYEYVEKVE--KMPSHR------ILALNRGEKED 233 Fusobacterium nuc... 15672267 160 LSEAISEDARLRSWLTGEIKNNSLLTSSL--KKDAv--dEKQVFQMYYEFSEKVS--ELPNYR------VLALNRGEKLG 227 Lactococcus lacti... 15927638 164 IAEQISDNPKYRTKILKDMYHQGVLTTSK--KKNAe--dEKGIFEMYYAYSEPIK--RIANHR------VLAVNRGEKEK 231 Staphylococcus au... 15900789 161 LVEALSEDVTLRSMTYQEVLRHSKLTSQA--KDESl--dEKQVFQIYYDFSETVG--TMQGYR------TLALNRGEKLG 228 Streptococcus pne... 19115399 418 LAEEIIHDPQFRKSFRDKLYNAGVVTVLAtQKGVRkigsEHPYYEFKYLKRKPLGsfELEPIL------FLKMLKAEEEG 491 fission yeast 15674668 162 LVEAMSEDAKLRSWTYNEIWQYSRLVSTL--KDEQl--dEKKVFQIYYDFSDQVS--NMQGYR------TLALNRGEKLG 229 Streptococcus pyo... 15639909 184 LAEETAHCNANRAALKSFYLSAGVVTATG-IGDAHa--aHTSVYQMYWDYAEAVR--DIKAHR------VLAINRGEREG 252 Treponema pallidum 13357585 164 IAQKVANDTTLREMLYETINKHAKLITRI--NKITn--dPTKNFALYYEFSCPIK--YLKAYQ------LMAIDRANELK 231 Ureaplasma urealy... 16799970 169 IAEQISDEPTFREWIRNFTRKFGMIESRA--KNAEa--dEKGVYEMYYEFNEMIG--KVASHR------ILAFNRGEKED 236 Listeria innocua
134854 652 LLSVKLHMSS-QAQYIEHLFQIALETTNTSDIAiEWNNFRKLAFNQAMDK-IFQDISQEVKDNLTKNCQKLVAKTVRHKF 729 baker's yeast 19703417 234 ILTVHLRLEDs---DRERIENMILREFPKND----LASTYKEIIKDSLDRlIVPSIEREVRNALTERAEIESIAVFKDNL 306 Fusobacterium nuc... 15672267 228 ILSVKFEN------NEDKILRYFAARFAAQNN-----PMMQVAIKDAVKKkLIPAMERSIRTELTEKAEASAIEVFGENL 296 Lactococcus lacti... 15927638 232 VLSVKFEF------DTTSVEDFIARQEINHNN--VNRSYILEAIKDSLKRlIVPSIEREIHADLTEKAENHAIDVFSENL 303 Staphylococcus au... 15900789 229 VLKIGFEH------ATDRILAFFATRFKVKN------AYIDEVVQQSVKKkVLPAIERRIRTELTEKAEEGAIQLFSDNL 296 Streptococcus pne... 19115399 492 LIQLSIEFEDpDDVFKGLLELFVSDNFSENAMQ---WNAQRELVLKEVFKrFSALAPDAIRETLRSRYLDELGMRCRNQL 568 fission yeast 15674668 230 ILKVSFEH------NLEKMQRFFSVRFKETN------PYIEEVINQTIKKkIVPAMERRVRSELSDAAEDGAIHLFSENL 297 Streptococcus pyo... 15639909 253 ILDVKITV------DLDAAVEQVQEAVHPNN------RYHRDAITDGVVRlLSPAVLREIRADLTASAEQHGINVFSENL 320 Treponema pallidum 13357585 232 IIAFKLDF------KKEFLIDFAVNKYTRKIKS-NSYDYIKSAVNDGFDRlLIPSVSNAVYKEKLEEAHQQSAQIFSNNL 304 Ureaplasma urealy... 16799970 237 ILRVQVQV------DTTKIFQYLFEKVIQNRNS-ATRTYVEEAILDAYKRfIGPAIEREIRGELTDKAEEQAIHIFSENL 309 Listeria innocua
134854 730 MTKLDQAPFIPNvrdpkipKILSLTCGqGRFGadAIIAVYVNRkGDFIRDYKIVDNPFDKTn-PEKFEDTLDNI------ 802 baker's yeast 19703417 307 KNLLLQAPLKEK-------NILALDPG-YRTG--CKVAVIDKY-GFYRENTVFFLVEAMHN--PRQIQDAREKFlkl--- 370 Fusobacterium nuc... 15672267 297 KNLLLVAPLKGR-------VVMGFDPA-YRTG--AKLAIVDET-GKLLMTTVIYPVKPANA--GQIAQAK-KDLakf--- 359 Lactococcus lacti... 15927638 304 RNLLLQPPMKGK-------QILGVDPA-FRTG--CKLAVINPF-GTFIAKGVIYPHPPVSK--KEAAE---KDFvqm--- 364 Staphylococcus au... 15900789 297 RNLLLVAPLKGR-------VVLGFDPA-FRTG--AKLAVVDAT-GKMLTTQVIYPVKPASA--RQIEEAK-KDLadl--- 359 Streptococcus pne... 19115399 569 FSRLDQAPYEP--------STKNFDRG-TIP---SVLAVSNGK-GESSDAIICVFVDDVGEptDSLKLADLRDLanqamf 635 fission yeast 15674668 298 RHLLLVSPLKGK-------MVLGFDPA-FRTG--AKLAIVDQT-GKLLTTQVIYPVAPASQ--TKIQAAK-ETLtql--- 360 Streptococcus pyo... 15639909 321 TNLLMTQPVKGT-------RVLGIDPG-IRTG--TKCAALDET-GQYLGSFVIYPHN------TDHARAALTQAl----- 378 Treponema pallidum 13357585 305 QQLLLQKPLKSH-------VVLGFDPG-YVHG--CKLAIVNKN-NQLLHTDIIYPHKPQIL--ITQAKNTLISLi----- 366 Ureaplasma urealy... 16799970 310 RKLLLQPPLKGK-------IILGVDPA-FRTG--CKFSVLDQT-GKVLEIGVVYPHTAKAR--RPEAK---QKIaei--- 370 Listeria innocua
134854 803 ---IQSCQPNAIGINGPNPKTQKFYKrlqEVLHKKQivdsrGHTIPIIYVEDEVAIRYQNSERAAQEFPNKPPLVKYCIA 879 baker's yeast 19703417 371 -vkKYDIDIVSIGNGTASRETETFVA---NIIREE------KLNVKYLIVNEAGASVYSASKIAAEEFPDLDVTVRGAIS 440 Fusobacterium nuc... 15672267 360 -irEYGVNMIAIGNGTASRESESFVA---EVLKENN-----FSDVYYVIVSESGASVYSASELAREEFPELTVEKRSAIS 430 Lactococcus lacti... 15927638 365 -vkAYDVQLIAIGNGTASRETEQFVA---DLIKKH------QLPVQFIIVNEAGASVYSASEIARDEFPDFQVEERSAVS 434 Staphylococcus au... 15900789 360 -igQYGVEIIAIGNGTASRESEAFVA---EVLKD-------FPEVSYVIVNESGASVYSASELARQEFPDLTVEKRSAIS 428 Streptococcus pne... 19115399 636 aefVEKVKPDVIGVSGMSVSAHKIRQ---HVQDSLTs----HEPVDLIMVNDEVARLYQNSTRAVDEFPTLPTISCYCVA 708 fission yeast 15674668 361 -ieTYQIDIIAIGNGTASRESEAFVA---DVLKD-------FPNTSYVIVNESGASVYSASELARHEFPDLTVEKRSAIS 429 Streptococcus pyo... 15639909 379 --dRYRIQLVAVGNGTGSHAVQELIA---SIISET------HSAVAFTVVEEDGASVYSAGDIAREEFPDLDLTIRGAIS 447 Treponema pallidum 13357585 367 --nKYEVNTIAIGNGTASNESVIFIS---DLIKEFK------LNLNYCVISEDGASIYSASSIASEEFPNLSVEKRSAIS 435 Ureaplasma urealy... 16799970 371 -lsTYQVEVIAIGNGTASRETEQFIV---EVIRES------KSNAYYCIVNEAGASVYSASETAREEFPDYQVEERSAVS 440 Listeria innocua
134854 880 LARYMHSPLLEYANLtseEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSVEVNKATdnnyyASALKYISGFGKRKA 959 baker's yeast 19703417 441 IGRRIQDPLAELVKI---DPKSIGVGMYQHDVNQSKLDESLDNVISHVVNNVGANINTAS-----WALLSHISGIKKTVA 512 Fusobacterium nuc... 15672267 431 IARRLQDPLAELVKI---EPKAIGVGQYQHDVSEKKLTENLDFVVETVVNQVGVNVNTAS-----PSLLSHVAGLNKSLA 502 Lactococcus lacti... 15927638 435 IGRRVQDPLSELVKI---DPKSIGVGQYQHDVNQKALENALTFVVETAVNQVGVDVNTAS-----SSLLQYVSGLSSQIA 506 Staphylococcus au... 15900789 429 IARRLQDPLAELVKI---DPKSIGVGQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTAS-----PALLSHVAGLNKTIS 500 Streptococcus pne... 19115399 709 LARYVQNPLFEYAAMg-rDLMSLSFDPWQHLLPPDVLWKYLETALVDISSLVGIDINEAVtnkyeANILPYIAGLGPRKA 787 fission yeast 15674668 430 IARRLQDPLAELVKI---DPKSIGVGQYQHDVSQKKLSENLGFVVDTVVNQVGVNVNTAS-----PSLLAHVSGLNKTIS 501 Streptococcus pyo... 15639909 448 IGRRLQDPLAELVKI---DPKSIGVGLYQHDVNQKKLSEELHAVVDAVVNSVGVNLNTAS-----VSLLKHVSGVNSALA 519 Treponema pallidum 13357585 436 IARRIIDPLSELIKI---DPKSIGVGQYQHDINKNILQQKVDFCIDYCVNQVGVDVNTAS-----IPLLSKVSGLNKRSA 507 Ureaplasma urealy... 16799970 441 IGRRLQDPLAELVKI---DPKSVGVGQYQHDVAQKRLNETLTFVVETAVNQVGVNVNTAS-----ASLLQYVAGLNKTVA 512 Listeria innocua
134854 960 IDFLQSLQRLNePLLARQQLITHNILHKTIFMNSAGFLYISWNEKRqkyedlehdqLDSTRIHPEDYHLATKVAADALEY 1039 baker's yeast 19703417 513 KNIVNYRKENG-NFKNRKQILKVKGVGPKAYEQMAGFLVIPEGENI----------LDNTVIHPESYGIAEAILGKIGFD 581 Fusobacterium nuc... 15672267 503 QNVVKYREENG-ALKTRAELKKVPRLGAKAFEQAAGFLRIPEGKNF----------LDNTGVHPESYKVTEQLLAEISAD 571 Lactococcus lacti... 15927638 507 KNIIAYREENG-AIKHNKELSKIKRLGAKTFEQSIGFLRIVDGSEP----------LDNTSIHPESYKVTYQLLDKLGFG 575 Staphylococcus au... 15900789 501 ENIVKYREEEG-KITSRAQIKKVPRLGAKAFEQAAGFLRIPESSNI----------LDNTGVHPENYTAVKELFKRLDIK 569 Streptococcus pne... 19115399 788 DYVLKKIAATGgRIDNRSDLISKQIMSRKVFINCSSFFIIPNDEYPnm------diLDSTRIHNEDYELARKMASDALEL 861 fission yeast 15674668 502 ENIVKYREENG-ALTSRADIKKVPRLGAKAFEQAAGFLRIPGAKNI----------LDNTGVHPESYPAVKELFKVLGIQ 570 Streptococcus pyo... 15639909 520 KRIVHHRATYG-IFTSREQLKTVSGMGQKTFEQCAGFLKIPESTNP----------LDNSWVHPENYATGKIIFDILRAG 588 Treponema pallidum 13357585 508 KKIFEYVKKHQ-FIENREQLKTIPYITDKVFEQAAGFLRINNANNF----------LDRTSIHPEAYLVVNELCKYLQLP 576 Ureaplasma urealy... 16799970 513 NNIRKYREENG-SFTSRKELKKVPRLGAKSYEQSIGFLRILEGENP----------LDKTAIHPESYKAAEQIVKAAGFG 581 Listeria innocua
134854 1040 DPDTIAEKEeqgtmsefiellredpdrRAKLESLNLESYAEElekntGLRKLNNLNTIVLELLDGFEELRNDFHPLQGDE 1119 baker's yeast 19703417 582 LEKYNNELDv----------------aRERLKSFDYKKFAKE-----NEFGLETVKDVYEALLKDRRDPRDDFEKPLLKS 640 Fusobacterium nuc... 15672267 572 KP-V--SNEe----------------lLTKLSSVNIPEMAEK-----LGLGQETLTDIINDLQKPGRDLRDSFDAPILRQ 627 Lactococcus lacti... 15927638 576 GNDL--GSDa----------------lKAKLNSLDMDELAIE-----LQVGVPTLEDIIKSLKAPNRDPRDEFDTPILKS 632 Staphylococcus au... 15900789 570 D-----LNEe----------------aQSKLKSLSVKEMAQE-----LDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQ 623 Streptococcus pne... 19115399 862 DEEDIEELEtnrgvvy----hlleeneTGKLDELVLEEYADQlerefHQKKRNTLEKIRLELKDPYGEQRNVFHKLTPSE 937 fission yeast 15674668 571 D-----LDDa----------------aKATLAAVQVPQMAET-----LAIGQETLKDIIADLLKPGRDLRDDFEAPILRQ 624 Streptococcus pyo... 15639909 589 G----------------------------TVSAAQKAQVQSQ-----CAVSDRTVEDIITELQKPNRDPREDYPKPVLRQ 635 Treponema pallidum 13357585 577 INKLINN--------------------YQVLNQLNPNELTTI-----LKTDIYTIENIINNLKNPLQDVRDDYDIPILRS 631 Ureaplasma urealy... 16799970 582 LNDI--GSEd----------------lKAALQALSIPEEAEK-----LGIGKETMRDIIDNLIAPGRDLRDELPAPLLKQ 638 Listeria innocua
134854 1120 IFQSLTgesekTFFKGSIIPVRVERFWHNDIICTTNSEVECVVNAQRHAGAQLRRPaNEIYEIGKTYPAKVIYIDYANIT 1199 baker's yeast 19703417 641 DILNID-----NLEVGMELEGTVRNVVKFGAFIDIGLKNDALLHISEISDKYIDDP-SKVLSVGQIIKVKIKDVDKDRGR 714 Fusobacterium nuc... 15672267 628 DVLSAG-----DLQIGQQLEGVVRNVVDFGAFIDIGIKNDGLAHVSDLSKSFVKNP-SDVVAVGQIVTVWVKSLDLQRGK 701 Lactococcus lacti... 15927638 633 DVLSIE-----DLKEGMKLSGTVRNVVDFGAFVDIGVKQDGLVHVSKLSKKFVKNP-MDIVSVGDIVDVWVYSIDKNKDK 706 Staphylococcus au... 15900789 624 DVLDIK-----DLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHMSRKFIKHP-SQVVAVGDLVSVWVKKIDTEREK 697 Streptococcus pne... 19115399 938 IFLMLTgenpeELQADAIVPVNVRRVTNRFVAVKLDCGIDGNIKADEVSDDFIP-P-PQLLQVGQTVEGVIISLDEANFM 1015 fission yeast 15674668 625 DILDLK-----DLEIGQKLEGTVRNVVDFGAFVDIGVHEDGLIHISEMSKTFVNHP-SQVVSVGDLVTVWVSKIDLDRHK 698 Streptococcus pyo... 15639909 636 GLISFA-----DLKVGATVQGKVKNVVDFGAFVDIGIKETALLHVSQMSDHFVSNP-LKKVKVGDVYTCTIIGLDEARRR 709 Treponema pallidum 13357585 632 QMVDIN-----NLKIGMLVQGTIRNQTEFGSFIDIGLKNDALLHISNYCE-------EDNLHVNKNINVYIDKIDTITQK 699 Ureaplasma urealy... 16799970 639 DVISME-----DLKQGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLSNSFVKNP-MDVVSVGDVVTVWVDEVDTKKNR 712 Listeria innocua
134854 1200 AEVSLLDHDVKQQyvpiSYSKDps-iwDLKQELEdaeeERKLmmaearakRTHRVINHPYYFPFNGRQAEDYLRSKERG 1277 baker's yeast 19703417 715 VGLTRKGQN---------------------------------------------------------------------- 723 Fusobacterium nucl... 15672267 702 INLTLVNPREK-------------------------------------------------------------------- 712 Lactococcus lactis... 15927638 707 VSLTMIDPHE--------------------------------------------------------------------- 716 Staphylococcus aur... 15900789 698 VNLSLLAPNETD------------------------------------------------------------------- 709 Streptococcus pneu... 19115399 1016 VDLSLRNSVLQSAnskrQTSSHrtsywDTEAEKRdterMQAEtqa---eqRVARVIKHPLFKDLNASQAEAYLSKMQVG 1091 fission yeast 15674668 699 VNLSLLPPRDTH------------------------------------------------------------------- 710 Streptococcus pyog... 15639909 710 ISLSLRQEQRAPAdhtaTPSRRa---pRPRAPEG----KTSP--------ERAKTRGTSPAPGQDFARYQPFAQFFKGK 773 Treponema pallidum 13357585 700 ISLKLKL------------------------------------------------------------------------ 706 Ureaplasma urealyt... 16799970 713 IALTMRNPDGSVK------------------------------------------------------------------ 725 Listeria innocua
Jiyao W et al.(2023). "The conserved domain database in 2023.",