3LKM,1IA9


Conserved Protein Domain Family
Alpha_kinase
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smart00811: Alpha_kinase 
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Alpha-kinase family
This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.
Links
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Statistics
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PSSM-Id: 214828
Aligned: 34 rows
Threshold Bit Score: 133.249
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LKM_A      34 IINKWIRLSMK--L--KV--ERK--PFAEG-ALREAYHTvslgvgtdenyplgtttklfppiemispisknnEAMTQ--- 101  Dictyostelium di...
XP_647583  390 SSYEMKLNEIT--IsiKI--APN--PFSHG-ACRLAYLG---------------------------------IDE----- 424  Dictyostelium di...
XP_962102  431 RDNNDGLSMLM--L--TI--YKRrlPFAKG-KLRMASYA---------------------------------RTVS---- 466  Neurospora crass...
XP_961224  535 SDTNMPVSVFG--L--NLckRRT--PFAKG-ALRLASFA---------------------------------CT------ 568  Neurospora crass...
XP_656642   45 RINQFLFQHST--F--RV--ELA--PFAKG-GERLAFRA---------------------------------IN------ 76   Entamoeba histol...
XP_652177  289 rplLYRVQPTV--L--SK--NKY--PFARG-GIRNAYHG---------------------------------I---N--- 320  Entamoeba histol...
XP_651695   33 HIDKFKLKRER--I--EA--RSA--SFGKG-GERTAFEG---------------------------------IFT----- 65   Entamoeba histol...
BAE64431    53 YNNSNKCSVPN--S--AL---KN--SFAQG-AFRWVAKG---------------------------------SYTSG--- 86   Aspergillus oryz...
NP_065829 1596 dSGCWGDKLFGrlV--SE--ELR--GGGYGcGLRKASQA---------------------------------KVIYGlep 1636 human
XP_654603  255 cpefgICYSGE--I--NI--ADF--PFGVG-AVRVAFHG---------------------------------FDMDK--- 289  Entamoeba histol...

3LKM_A     102 -LKNGTKFVLKL-----YKKEAE-------QQAsRELYFE----DVKMQMVCRDWGNKF--------------------- 143  Dictyostelium di...
XP_647583  425 ---HGKKVVLKQ-----SKYIGG-------RENsKKRYFE----SMECQTVAAKFALEF--------------------- 464  Dictyostelium di...
XP_962102  467 ---STNSYVAKS-----FIKKAP-------Q---IAYLVE----DMRCQALCKAFALEF--------------------- 503  Neurospora crass...
XP_961224  569 -ECSRSRHVVKE-----FKTDGDdeddgsgNRS-LAHLVD----DMRSQALCKAFALEF--------------------- 616  Neurospora crass...
XP_656642   77 --GRGDRIVLKR-----FFQQRP-------LTM----LLE----TIERQLICIYLANIF--------------------- 113  Entamoeba histol...
XP_652177  321 -KLTKTKIVLKD-----FIEPTF-------ASL-TK-YLH----SLELNCAVEELASEF--------------------- 360  Entamoeba histol...
XP_651695   66 --KSEREIVLKR-----FNK----------ERK-FDVFIE----TIEKQCVCSSLAIEF--------------------- 102  Entamoeba histol...
BAE64431    87 -SRRGQACVVKW-----FKTGAV-------FS---DDYFTl---DIKAVDKALEIVNRF--------------------- 126  Aspergillus oryz...
NP_065829 1637 iFESGRTCIIKVssllvFGPSSE-------TSL-VGRNYDvtiqGCKIQNMSREYCKIF--------------------- 1687 human
XP_654603  290 -----NEIIIKQ-----FKTKNM-------MGF--ESYVD----TVAMHLQCQYISRLFesyisllkegktneeitmldi 346  Entamoeba histol...

3LKM_A     144 ---------NQ----K---KP-P------------KKIEFLMSWVV-----EL--ID--RS-----------PssngqPI 174  Dictyostelium di...
XP_647583  465 ---------NKql-sL---TSsE------------HQITFTVAKVL-----QM--KH--SE-----------K-----PM 494  Dictyostelium di...
XP_962102  504 ---------NA----Ll-vDSsR------------HSIDFIATACF-----KG--KSelKS-----------G-----DE 534  Neurospora crass...
XP_961224  617 ---------NS----LladCP-E------------HNIDFVVTSCF-----KC--ND--RR-----------G-----SQ 645  Neurospora crass...
XP_656642  114 ---------NK----L---NVsP------------NKLHFLPNYLF-----IPspTK--DL-----------D-----GK 142  Entamoeba histol...
XP_652177  361 ---------NQ----I---NTsF------------KRIKFIPTYLFvecdqHL--IG--KPvlsyeelmmvcK-----KQ 403  Entamoeba histol...
XP_651695  103 ---------NQ----L---HVtE------------KQIQFIPTTLF-----IS--NS--FK-----------G-----IY 129  Entamoeba histol...
BAE64431   127 ---------NQ----L---NIiN------------KVVKINVPEIW-----HF--TD--DS-----------S-----DE 153  Aspergillus oryz...
NP_065829 1688 ---------AAearaA---PGfG------------EVPEIIPLYLI-----YR--PA--NN-----------I-----PY 1718 human
XP_654603  347 rarkeelesNK----T---RTtEneekerneldsiKKVTFIPLRLF-----IE--TP--RT-----------S-----SL 394  Entamoeba histol...

3LKM_A     175 -----------------------L----CS-----------------IEPLLVGEFKKNNSNY-GAVLTn--RST----- 202  Dictyostelium di...
XP_647583  495 -----------------------Y----FG-----------------IETFINGEYQKYNSNC-GWLKDd-aMSe----- 523  Dictyostelium di...
XP_962102  535 -----------------------L----IS-----------------IEPYIGVDYVKYNTNA-GWVNDfqdPSNe---- 565  Neurospora crass...
XP_961224  646 g---------------------kC----MS-----------------IEPFLAGKFVKYNGNA-GYANKe-aNLThdpsn 681  Neurospora crass...
XP_656642  143 -----------------------I----LTleqteqavaatcrtpnfVEPYLSGYFIKYIDNN-GWINEs-eFHSt---- 189  Entamoeba histol...
XP_652177  404 -----------------------I----YF-----------------VEPELNGEFIKFNDNN-SWVNSe-mYSAt---- 433  Entamoeba histol...
XP_651695  130 dekilnkke------lepliengI----FL-----------------VEPLLHGEFIKFNCNN-GNLWFd-sYHAt---- 176  Entamoeba histol...
BAE64431   154 -----------------------WagqrHL-----------------CEPFIQ-NYQKFNSNT-GWNDDs-kAWGe---- 186  Aspergillus oryz...
NP_065829 1719 ----------------------------AT-----------------LEEDLGKPLESYCSREwGCAEAp-tASGsseam 1752 human
XP_654603  395 rrqffdskkisvneiermavgktI----WF-----------------IEQPLVGSFEKYNSNN-SSVNYc-nYSYt---- 447  Entamoeba histol...

3LKM_A     203 --PQAFSHFTYELSNKQMIVVDIQGV------D------DLYTDPQI--HTP--D--GKGFGLGNLGKAGINKFITTHKC 262  Dictyostelium di...
XP_647583  524 -iLQTFSHWTYQESKNKAIVVDIQGVkt--skG------YLLTDPAI--HST--D--TLRFGSCNLGKPGIIKFFQSHKC 588  Dictyostelium di...
XP_962102  566 -aAQAFSHFTFERSRGAFLASDLQGV------N------GLLTDPVI--HTR--DenRFPLSKANLGVDGFKFFFATHEC 628  Neurospora crass...
XP_961224  682 qaAQAFSHFTFERSRGRFLVCDLQGV------G------KTMTDPAI--HTL--DpyRFSLSQTNLGAEGFMFFFAYHEC 745  Neurospora crass...
XP_656642  190 --LHAFAHWTWVHTKGALLICDIQGV------Nan--nkFYLTDPAL--HHI--DqnKFIYSETNLGEVGISQFFRTHQC 255  Entamoeba histol...
XP_652177  434 --aQAFSHWTYFRTAKRLIVVDLQGVinkeksE------YILTDPAV--HHE--SqsKYFFSSTNLGQNGIAHFFESHQC 501  Entamoeba histol...
XP_651695  177 --LHAFSHWSWCISNHQLIIVDLQGIqi--gnC------FYLTDPAIlsISE--N--KFSNSSTNLGEEGISRFFETHYC 242  Entamoeba histol...
BAE64431   187 -vMQALSHFSYHISGGNYVLCDLQGGiy--qhE------LVLSDPVI--LSR-----TREYGVTDLGPDGISSFFSLHAY 250  Aspergillus oryz...
NP_065829 1753 qkCQTFQHWLYQWTNGSFLVTDLAGV------D------WKMTDVQI--ATK--Lr-GYQGLKESCFPALLDRFASSHQC 1815 human
XP_654603  448 --MQCFSHFSYFISSQSFIITDLQGV------FrkednlYELTDPAI--HHQflS--HYFFAFTNLGNTGINQFFITHKC 515  Entamoeba histol...

3LKM_A     263 NAVC 266  Dictyostelium discoideum
XP_647583  589 NQHC 592  Dictyostelium discoideum AX4
XP_962102  629 NDIC 632  Neurospora crassa OR74A
XP_961224  746 NHLC 749  Neurospora crassa OR74A
XP_656642  256 NAIC 259  Entamoeba histolytica HM-1:IMSS
XP_652177  502 NAVC 505  Entamoeba histolytica HM-1:IMSS
XP_651695  243 NQIC 246  Entamoeba histolytica HM-1:IMSS
BAE64431   251 NNFY 254  Aspergillus oryzae RIB40
NP_065829 1816 NAYC 1819 human
XP_654603  516 NKYC 519  Entamoeba histolytica HM-1:IMSS
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