3RCZ,1JAT,2UCZ,3ONG,3O2U,2GMI,2GRN,1Y6L,1FXT,2C2V,1C4Z,2E2C,1I7K,3RZ3,3K9P,2Z5D,1ZDN


Conserved Protein Domain Family
UBCc
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smart00212: UBCc 
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Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.
Links
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Statistics
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PSSM-Id: 214562
Aligned: 65 rows
Threshold Bit Score: 81.5716
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3RCZ_B        14 RLQEERKQWRRDHPFGFYAKPCKSs---DggldLMNWKVG--IPGKPKTSWEGGL----------YKLTMAFPEEYPTRP 78  fission yeast
EDN63076       9 RLTKEYKLMVENPPPYILARPNED----N----ILEWHYI--ITGPADTPYKGGQ----------YHGTLTFPSDYPYKP 68  Saccharomyces c...
BAA13909       3 RLMKEYLALQKNPFELVDAKPATE----N----ILEWHYI--ITGPPDTPYEGGQ----------YHGTLIFPPDYPFKP 62  fission yeast
XP_001142548 190 RLLEELEEGQKGVGDGTVSWGLEDdedmT----LTRWTGM--IIGPPRTNYENRI----------YSLKVECGPKYPEAP 253 chimpanzee
NP_009919     37 allDNFHSLRPRTRVFTHSDGTPQ----L----LLSIYGT--ISTGEDGSSPHS-----------IPVIMWVPSMYPVKP 95  Saccharomyces c...
XP_002755157  23 RETVNVITLYKDLKPVLDSYVFND----G----SSRELMN--LTGTIPVPYRGNTy--------nIPICLWLLDTYPYNP 84  white-tufted-ea...
2GMI_B         9 RLLEELEKGEKGFGPESCSYGLADsddiT----MTKWNGT--ILGPPHSNHENRI----------YSLSIDCGPNYPDSP 72  baker's yeast
CAB06793      16 WLFKVIQPIYDDGRRTFHDSLALLdkfhR----LRPRTRV--FTHSDGSPQLLLSiygt--vgdsLPLIMWIPSLYPVKP 87  lager yeast
NP_001040755  14 RLMKEAMELRQPTEMYHAQPMED-----N----LFEWHFT--IRGTLGTDFEGGI----------YHGRIIFPADYPMKP 72  nematode
AAO85552     218 RLMKEIRDIHRSEHFKNGIYTFELekeeN----LYQWWIKlhKVDEDSPLFEDMKklkkdhnqdhLLFSFTFNEKFPCDP 293 nematode

3RCZ_B        79 PKCRFTPP-----------LFHPNVY-PSGTVCLSIL--Ne-eEGWKPA-ITIKQILLGI-QDLLDDPNIASPAQT---- 137 fission yeast
EDN63076      69 PAIRMITP-------------NGRFK-PNTRLCLSMSdyHp--DTWNPG-WSVSTILNGL-LSFMTSDEATTGSIT---- 126 Saccharomyces c...
BAA13909      63 PAIRMITP-------------SGRFQ-TNTRLCLSFSdfHp--KSWNPS-WMVSTILVGL-VSFMTSDEITTGGIVtses 124 fission yeast
XP_001142548 254 PSVRFVTK-----------INMNGINnSSGMVDARSI--Pv-lAKWQNSySIKVVLQELR-RLMMSKENMKLPQPP---- 314 chimpanzee
NP_009919     96 PFISINLEnfdmntissslPIQEYID-SNGWIALPIL--H----CWDPAaMNLIMVVQEL-MSLLHEPPQDQAPSL---- 163 Saccharomyces c...
XP_002755157  85 PICFVKPTssm------tiKTGKHVD-ANGKIYLPYL--H----EWKHPqSDLLGLIQVMiVVFGDEPPVFSRPIS---- 147 white-tufted-ea...
2GMI_B        73 PKVTFISK-----------INLPCVNpTTGEVQTDFH--Tl--RDWKRAyTMETLLLDLR-KEMATPANKKLRQPK---- 132 baker's yeast
CAB06793      88 PFISIDLEtfdvsaissslPVQAYID-SDGRVALPIL--D----HWNPAtMGLIVVVQEL-MSLLSEPSRDRVPSL---- 155 lager yeast
NP_001040755  73 PNLILLTP-------------NGRFE-LNKKVCLSIS--GyhpETWLPS-WSIRTALLAL-IGFLPSTPGGALGSL---- 130 nematode
AAO85552     294 PFVRVVAP-----------HINQGFVlGGGAICMELL--Tk--QGWSSA-YSIESCILQI-AATLVKGRARISFDA---- 352 nematode

3RCZ_B       138 -------EAYTMFKK-------------------------------------------------------------DKVE 149 fission yeast
EDN63076     127 -------TSDHQKKTlarnsi--------------------------------------------------syntfQNVR 149 Saccharomyces c...
BAA13909     125 trrtyakDTKRFNIM-------------------------------------------------------------DNPK 143 fission yeast
XP_001142548 315 -------EGQTYNN------------------------------------------------------------------ 321 chimpanzee
NP_009919    164 -------PPKPNTQLqqeqntpplppkpksphlkpplppppppqpasnaldlmdmdntdisptnhhemlqnlqtvvnely 236 Saccharomyces c...
XP_002755157 148 -------TSYPPYQAtgppntsympgmpggissypsgyppnprcghlfegkllsnivsyleselvsyrtilmkgskqvsl 220 white-tufted-ea...
2GMI_B       133 -------EGETF-------------------------------------------------------------------- 137 baker's yeast
CAB06793     156 -------PPKPDAMHsplkhtvpplppkakfphvqpplqpppppqppssavdlmdmdntdlsptnhhemlqnlqsvLNEL 228 lager yeast
NP_001040755 131 -------DYPPKERQrl---------------------------------------------------------akLSCE 146 nematode
AAO85552     353 -------KHTSTYSMa-----------------------------------------------------------rAQQS 366 nematode

3RCZ_B       150 YEKRVRAQARENAP 163 fission yeast
EDN63076     150 FKLIFPEVVQENVE 163 Saccharomyces cerevisiae YJM789
BAA13909     144 FLIMFPELIDKNRE 157 fission yeast
XP_001142548     --------------     chimpanzee
NP_009919    237 redvdyvadkiltr 250 Saccharomyces cerevisiae S288c
XP_002755157 221 llfpagpsrdgtis 234 white-tufted-ear marmoset
2GMI_B           --------------     baker's yeast
CAB06793     229 YREDVHYVADKILT 242 lager yeast
NP_001040755 147 WKCKECGCVMKTAL 160 nematode
AAO85552     367 FKSLQQIHAKSGwy 380 nematode
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