3HIZ,3APC,2Y3A,2WXF


Conserved Protein Domain Family
PI3Ka

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smart00145: PI3Ka 
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Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation.
Statistics
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PSSM-Id: 214537
Aligned: 26 rows
Threshold Bit Score: 153.567
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HIZ_A     549 NElRENDKEQLKAISTRDPLSEITEQEKDFLWSHRhYCvT-IPEI----------LPKLL--LS-VKWNSRDEVAQMYCL 614  human
NP_524028 1036 ASlDANLQEELLDTAEL--GYTGATERREVFWEKR-LYlQsYPNA----------LPKVL--HAaHSWDYAN-LIDLHAL 1099 fruit fly
Q94125     606 CIrDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRrYIqKqEPDL----------LI-VLseLA-FVWTDRENFSELYVM 673  nematode
NP_510529  780 ATlDIETQEYLLELIENQDTSTLETDDQDLIWQKR-LHlTnQPEA----------LPLVL--SSlQDWSFGF-VMRVYQI 845  nematode
AAC49133   261 KPnSKIRKE-LESILSYPPSEELSLEEKDLIWKFR-FYlTrNKKA----------MTKFL--KS-VVWTDSSEVNQALSL 325  fission yeast
NP_013341  298 KP-DIKKRDYLNKIINYPPGTKLTAHEKGSIWKYR-YYlMnNKKA----------LTKLL--QS-TNLREESERVEVLEL 362  Saccharomyces ce...
BAG37317   298 lawSISPYLAVQLPARFKNTEAIGNEVTRLV-RLDpGAvSdVPEA----------I-KFL-----VTWHTIDADAPELSH 360  human
Q92213     335 KPtPQLRDE-LLRIMIKPSNAESTDNEKNLIWKFRyYFsKnNSGNdpsnksvksfLPKFL--RS-INWENDYELDHTFKE 410  Candida albicans
CAA87094   287 KP-YPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFR-YYlTnQDKA----------LTKIL--TS-VIWDLPQGAKQALAL 351  human
CAA68185   288 NPtASIRDQLHTIVYRYPPTYVLSSEEQDLLWKFRfYLs-sHKKA----------LTKFL--KC-INWKLEDEVTQALWM 353  fruit fly
3HIZ_A     615 VK--DW--PPIKPEQAMELLD----------CNYP-D------------------------PMVRGFAVRCL-EKyLTDD 654  human
NP_524028 1100 LH--SW--APLSPLQSLELLL----------PRYP-D------------------------AKVREKAVEWI-SK-MPND 1138 fruit fly
Q94125     674 LE--KW--KPPSVAAALTLLG----------KRCT-D------------------------RVIRKFAVEKLnEQ-LSPV 713  nematode
NP_510529  846 LE--EW--APLRPEIAMEFLL----------PKYP-D------------------------ERIRAHAVQSL-AR-GSTD 884  nematode
AAC49133   326 LD--SW--TEIDIDDALELLS----------PSFV-H------------------------PKVRAYAVSRL-ET-ASNE 364  fission yeast
NP_013341  363 MD--SW--AEIDIDDALELLG----------STFK-N------------------------LSVRSYAVNRL-KK-ASDK 401  Saccharomyces ce...
BAG37317   361 VL--CW--APTDPPTGLSYFS----------SMYPpH------------------------PLTAQYGVKVL-RS-FPPD 400  human
Q92213     411 IIpfYWnvDKLQIGDALELLGdyfnpytlgkPTYQ-DdsmtsksskmksdekrfikiynnvCFLRKLAVERL-KL-ANSE 487  Candida albicans
CAA87094   352 LG--KW--NPMDVEDSLELIS----------SHYT-N------------------------PTVRRYAVARL-RQ-ADDE 390  human
CAA68185   354 LA--NW--APMDVEDALELLS----------PTFT-H------------------------PQVRKYAVSRL-AQ-APDE 392  fruit fly
3HIZ_A     655 KLSQ----------YLIQLVQVLKY-------E----------------------------------------------- 670  human
NP_524028 1139 QLVD----------FLPQLVQSLKH-------D----------------------------------------------- 1154 fruit fly
Q94125     714 TFHL----------FILPLIQALKY-------E----------------------------------------------- 729  nematode
NP_510529  885 FLYH----------TIPQFIEALRF-------E----------------------------------------------- 900  nematode
AAC49133   365 ELLL----------YLLQLVQALRYdnpissdE----------------------------------------------- 387  fission yeast
NP_013341  402 ELEL----------YLLQLVEAVCF-------Enl--------------------------------------------- 419  Saccharomyces ce...
BAG37317   401 AILF----------YIPQIVQALRY-------D----------------------------------------------- 416  human
Q92213     488 ELLLyllqlvqalkY-----EALIY-------Eksppfcers-------------------------------------- 517  Candida albicans
CAA87094   391 DLLM----------YLSQLVQALKY-------Enfddikngleptkkdsqssvsgnvsnsgins---------------- 437  human
CAA68185   393 DLLL----------YLLQLVQALKY-------Edprhivhlhgcifperdvvrsilddngslldqsslsdlsatssglhg 455  fruit fly
3HIZ_A     671 -----------------------------------------------------------------------QYLDNLLVR 679  human
NP_524028 1155 -----------------------------------------------------------------------TYEGSAMAR 1163 fruit fly
Q94125     730 -----------------------------------------------------------------------PRAQSEVGM 738  nematode
NP_510529  901 -----------------------------------------------------------------------LYEKSALAD 909  nematode
AAC49133   388 -----------------------------------------------------------------------RFQPSPLAL 396  fission yeast
NP_013341  420 ----------------------------------------------------------------------sTFSDKSNSE 429  Saccharomyces ce...
BAG37317   417 -------------------------------------------------------------------------KMGYVRE 423  human
Q92213     518 ---------------------------------------------------------------dqiednasSTLKSPLAD 534  Candida albicans
CAA87094   438 ----------------------------------------aeidssqiitsplpsvsspppasktkevpdgENLEQDLCT 477  human
CAA68185   456 svipanqraasvlaaiksdksvssgsaggsgsggqgsvalpnpsapatpgssslpcdsnsnalmlaegisfGSVPANLCT 535  fruit fly
3HIZ_A     680 F----------------LLKKALTNQ-------------------------------------RIGHFFFWHLKSE---- 702  human
NP_524028 1164 F----------------LLSKCLESP-------------------------------------RFAHHMYWLLVHS---- 1186 fruit fly
Q94125     739 M----------------LLTRALCDY-------------------------------------RIGHRLFWLLRAE---- 761  nematode
NP_510529  910 F----------------ILELSFVSL-------------------------------------DFTFEIYWQLQQRvdhc 936  nematode
AAC49133   397 F----------------LVNRAISSP-------------------------------------SIGNDLYWYLVVE---- 419  fission yeast
NP_013341  430 FtivdavssqklsgdsmLLSTSHANQkllksissesetsgteslpivisplaeflirralvnpRLGSFFYWYLKSE---- 505  Saccharomyces ce...
BAG37317   424 Y----------------ILWAASKSQ-------------------------------------LLAHQFIWNMKTN---- 446  human
Q92213     535 F----------------LIERAVENE-------------------------------------KLGNFFYWYVKVE---- 557  Candida albicans
CAA87094   478 F----------------LISRASKNS-------------------------------------TLANYLYWYVIVE---- 500  human
CAA68185   536 F----------------LIQRACTNA-------------------------------------TLANYFYWYLSIE---- 558  fruit fly
3HIZ_A     703 -M------HN----KT----V--SQRFGLLLESYCRACGM-YLKHLNR 732  human
NP_524028 1187 -Lp-----DD----PH----N--SIGAAMVDQEYDESQVT-QVRYYRR 1217 fruit fly
Q94125     762 -Iar---lRD----CDlkseE--YRRISLLMEAYLRGNEE-HIKIITR 798  nematode
NP_510529  937 aV------DD----LP----Y--AIRCQNLQQKMIDEHENpNLKTDIK 968  nematode
AAC49133   420 -I------ED----EP----V--SKLFSSVMFLFQKELSK-SVEGRLi 449  fission yeast
NP_013341  506 -S------ED----KP----Y--LDQILSSFWSRLDKKSR-NILNDqv 535  Saccharomyces cerevisiae S288c
BAG37317   447 -Iyl---dEE----GH----Qk-DPDIGDLLDQLVEEItgslsgpakd 481  human
Q92213     558 -N------EDqlnnPH----I--DGPIKIYMDILNRYIEL-LKAHCHE 591  Candida albicans
CAA87094   501 -C------ED----QD----T--QQRDPKTHEMYLNVMRR-FSQALLK 530  human
CAA68185   559 -VeevesvRK----QD----EraHDMYAMVLKMFLKVLEN-GNFNLRG 596  fruit fly
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