1DG3


Conserved Protein Domain Family
GBP_C
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pfam02841: GBP_C (this model, PSSM-Id:202427 is obsolete and has been replaced by 460721)
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Guanylate-binding protein, C-terminal domain
Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.
Links
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Statistics
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PSSM-Id: 202427
Aligned: 24 rows
Threshold Bit Score: 273.394
Created: 21-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DG3_A       284 GGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKV-QLPTESLQELLDLHRDSER 362 human
Q0IID3       284 GGIKASGSHLENLVQTYVNAINSGDLPCMESEVLTLAQIKNLAAVQKAIAHYDQKMGQKL-QLPTETFQELLDLHRASEK 362 cattle
Q8CFB4       283 GGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENSAAVQKAIGHYDQLMSEKV-QLPTETLQELLDLHRTCER 361 house mouse
Q8N4Q4       177 GGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKV-QLPMETLQELLDLHRTSER 255 human
Q0IJ14       282 GGLLVTGRMLAHLTSLYIETIMSGSVPCMENAILALSVIENTGAVQDALAKYETCMNEHLpRFPTETLQEFLHLHQGSEK 361 western clawed ...
Q7T0S6       283 GGLLVTGRMLAYLVNLYIETIKSGSVPCIENAVLALSVKENTGAVQDALKMYETCMNDQVaRFPTETLETFLQMHQDCEK 362 African clawed ...
Q6DHP7       283 GGHKVTGKLLGHLAKIYVDTISSGKVPCLDNAVVALANLENKCAVEEAFKVYERGMEEVKkTFPVN-VDEISSEHQRFSS 361 zebrafish
Q6YLY1       276 GGHTLTGEMLGHLVTTYVETIAKGNVPCLENAVLAMAKIENQAAVNEGLAVYQKGMEDVKaLFPVD-VNQLSENHLQSET 354 rainbow trout
Q66J21       276 GFRPANGNMLGDLAQKYTEAISNGHAPCMENAVLSLSENENNAAVEKALEHYETEMVKKV-VFPTETMNQFMDLSKECEQ 354 African clawed ...
NP_001091339 281 GGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIENSRAVQKALAKYEEEMSKNIgKFPTETQEEFLNIHQECEI 360 African clawed ...

1DG3_A       363 EAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQD 442 human
Q0IID3       363 EAIEVFMKNSFKDEDQGYQKKLEMQLAAKQNDFHERNLEASQNRCSALLQDIFHPLEENVKQGVYSKPGGHCLFIQQRDE 442 cattle
Q8CFB4       362 EAIEIFRKHSFKDEGEFFQKELESLLSAKQDEICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQ 441 house mouse
Q8N4Q4       256 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEE 335 human
Q0IJ14       362 EALEVFLKRSFNDENQDFQKEFKNLLDNKMKEFSERNERESTERCQTIIQKLSESLEQRISQGEFSKPGGHKLFLKEKMT 441 western clawed ...
Q7T0S6       363 EALKVFMKRSFNDENQKFQQEFKELLDGKMKEFSALNESKSTERCQIIIQQLSAALDQRISQGEFLKPGGYMLFLEEKRT 442 African clawed ...
Q6DHP7       362 LANAEFMKRSFKDEKQEYINQLKEKIDVYYGCLLEDNGLASKKKCEDLLKDLFSEMNKKLQDGVYSQPGGYELYCKDRDV 441 zebrafish
Q6YLY1       355 QATKAFMKRSFKDDNGEFLKALAEAIVNHSDDLFKQNKDASEKKCKALLENLSALMDQGMKEGTYATPGGYGLYCNHHDN 434 rainbow trout
Q66J21       355 QAVDIFMTRSFRDKDHRFQKELMGSIQKKKNELLKKNEEASVAYCDDLLSKLTNDLDKAITDGSYIVPGGYQKFKEEMDK 434 African clawed ...
NP_001091339 361 EATKVFMGLSFKDENGEYLTQLIHDLAAKKSKYSLYNEEESAKKCKAILQNLSGSLESDISDGKFSKPGGFKQFLAEKNS 440 African clawed ...

1DG3_A       443 LKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLHEMQRKNEQMMEQKER 522 human
Q0IID3       443 LKAKYNQEPRKGIQAEEALQKYLESKESMSVTILQTDLALTAMEKEM--EGITEEFIKAEAQRLMESLMQHQQMMESRKI 520 cattle
Q8CFB4       442 LKANYRQQPGKGTQAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAIRIQEEQRKAEMER 521 house mouse
Q8N4Q4       336 LKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETKKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER 415 human
Q0IJ14       442 IMEEYNTTPHKGLKSLEVLQEFISNKKATEAAILQADESLTAKEKEIAESQAETAEAERQRQILEEKEKYLQESMENQKK 521 western clawed ...
Q7T0S6       443 IMAKYDTAPQKGLKSLEVLQEFMNNLKAIEATILQADESLTAKEKQIAESQAEAEAAKRQMQILEEHARSLQESLENQKK 522 African clawed ...
Q6DHP7       442 IVEKYRREPNKGVLAEAVLHEFLNERGAEANSILYTDTKLTENDKKIQEEKERNALMQQKCEEEQEKRIESERMMAAEKV 521 zebrafish
Q6YLY1       435 IVAQYRAEPNKGVRAEEVLEQFLKDKSAESYSILQADKQLTKKEKQIQAEKKKTAELEQEKAAFREQQAEMERTIENNRI 514 rainbow trout
Q66J21       435 IVGQYNENATKGIKGDEVLQRFLKSKEGTGNTILISDKALDEKEKLKEAEKAKAESLMMERKVSNVKASQDEQKDDGQMN 514 African clawed ...
NP_001091339 441 LVDEYKSSKGKGVKALEILQEFLTEKETVEAAILQADQSLTIKEKEIEDQRVRTEAAEREKQILEEHNRRLEVDMENQKK 520 African clawed ...

1DG3_A       523 SYQEHLKQLTEKMENDRV-QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQ 580 human
Q0IID3       521 FHQEQVRL----METNRV-YQEALQQRAMERQLQEEVKKLKEKLQAENRKLHDELQNLL 574 cattle
Q8CFB4       522 QHQEQLRQ----IALEKA-RVAQEQQWILKQRAQEEADRIKAEQEAQLRALQQQLQHMR 575 house mouse
Q8N4Q4       416 LHQEQVRQ----MEIAKQ-NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQ 469 human
Q0IJ14       522 SFEQHEKMLIEKMEADRQ-KLIAENGRVIAQKLQEQNAMLTAGFQSKVNDLQREIADLN 579 western clawed frog
Q7T0S6       523 SYEQHEKMLIEKMESDRR-NLIAENELVINQKLQEQNAMRIAGLKSNVDALQREINELK 580 African clawed frog
Q6DHP7       522 RQDDQIKQMQEKFEKERE-QMQQETEKAIDSKLKEQEEMLNKGFKERADLLSEEINDLK 579 zebrafish
Q6YLY1       515 SQEKYLKKMKEMMEEEREsHQQQEFNRTLERRMQEQKDLLENGHKEKAELMRQEILEIK 573 rainbow trout
Q66J21       515 SFQINIQRLVEKLEDEKR-MMRDQIERLVSEKRREEELLIRQGSAQQAKLYAAQIQDLE 572 African clawed frog
NP_001091339 521 SLEDHKRLMEEKMVEERK-KIIEQNEWMIKEKLKEQEEVLKKGFSQESEMLKDQIKDLK 578 African clawed frog
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