Conserved Protein Domain Family
Sema_4F
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cd11261: Sema_4F 
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F)
Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200522
Aligned: 4 rows
Threshold Bit Score: 857.262
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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plexin bindingputative
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of semaphorin 4A to its receptor Plexin B1
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                      ###               
XP_003229876   3 RAAQRFSAEGASNFSVFQVDAH--TLYVGARDAIYALTLGSISQRPKKISWMVLKDHRDSCTQKGKKEAECQNFIRILQF 80  green anole
O95754        52 SCLTRFAVPHTYNYSVLLVDPAshTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAI 131 human
NP_035480     58 SYLTRFAAPHTYNYSALLVDPAshTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAI 137 house mouse
XP_001376627  76 PFLTRFSAPQTQNYSILLVDPVsnTLYVGARDAIFALPLPLTEGRAQRIDWPVPEAHRQICKKKGKKEADCHNYIRILAM 155 gray short-tail...

Feature 1                                                #                    # ## #             
XP_003229876  81 VNQSHLLVCGTFAFDPRCGYIKLSDFRSVEHMESGRGRCPFEPLQPSTAIMADGALYVATVGNFLGTEPLISRDTRNPAE 160 green anole
O95754       132 ANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAED 211 human
NP_035480    138 ANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAED 217 house mouse
XP_001376627 156 ANATHLLTCGTFAFDPQCGIIDVSSFHQVERLESGRGKCPFEPTQRSAAIMTGGVLYAASMNNFLGTEPIISRAIGPTEE 235 gray short-tail...

Feature 1          #  # #    #                               #                       ##### #     
XP_003229876 161 VIRTVISMTWLNDPEFVASAFVR---EGKDGEDDKIYFFFTETAREYDFYEKVKVARVARVCKGDLGGQKTLQKRWTTFL 237 green anole
O95754       212 WIRTDTLPSWLNAPAFVAAVALSpaeWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFL 291 human
NP_035480    218 WIRTETLSSWLNAPAFVAAMVLSpaeWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFL 297 house mouse
XP_001376627 236 RIRTEVTPAWLNAPKFVAAVSLSptdLGEEDGDTEIYFFFTETARDSDMYQPIKVPRVARVCAGDLGGLKTLQRRWTTFL 315 gray short-tail...

Feature 1                                                                                  ##    
XP_003229876 238 KAQLYCSDPKSGTVFNILRDVVTLPALDGAwNATIFYGVFAAQGREESGSAVCTYSMEAVRRAMEGHFKEFRRECDKWTR 317 green anole
O95754       292 KADLLCPGPEHGRASSVLQDVAVLRPELGA-GTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLP 370 human
NP_035480    298 KADLLCPGPEHGRASGVLQDMTELRPQPGA-GTPLFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLP 376 house mouse
XP_001376627 316 KAELLCPGPTHGRTSSILKDMTTLQLKPGT-GVPLFYGIFSSQWDGVSISAICAFHPRDIQSSMSGPFREFKHDCNRGMP 394 gray short-tail...

Feature 1                                       #   #  #                                         
XP_003229876 318 LTPSDVPHPRPGACVTSSTEg--IGSSLALPDRVLTFVRDHPLMDELVLPLDNAPVLVVPGARYLRLAIHRVASLSGQEH 395 green anole
O95754       371 VVDNDVPQPRPGECITNNMKlrhFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEY 450 human
NP_035480    377 VMDNEVPQPRPGECITNNMKfqqFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTSLSGKEY 456 house mouse
XP_001376627 395 VMDSEVPQPRPGMCITNQMKllgFGSSLSLPDRVLTFVRDHPLMDQPVSPADGHPLLIASNTIYHRVAAHRVTGLLGEEY 474 gray short-tail...

Feature 1                                                                     
XP_003229876 396 HVLYLGTEDGRVHKAVRIGPRLSLLEDLHLFAEPQPVRNLQLHQNWLYVASDTEVTQIPTS 456 green anole
O95754       451 DVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTT 511 human
NP_035480    457 DVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSHTEVTQVNTS 517 house mouse
XP_001376627 475 DVLYLGTGDGHLHRAVRIGSQLSILEDLTLFLEPQPVETLQLHDGWLLIGSGSEVTQINIT 535 gray short-tailed opossum

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