3HHR


Conserved Protein Domain Family
somatotropin_like
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cd10285: somatotropin_like 
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Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.
Links
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Statistics
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PSSM-Id: 198435
Aligned: 11 rows
Threshold Bit Score: 191.122
Created: 16-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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receptor
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding interface [polypeptide binding site]
Evidence:
  • Structure:3HHR: Human growth hormone binds to the extracellular domain of its receptor, contacts at 4 A
    - View structure with Cn3D
  • Citation:PMID 1549776
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #  ## #  ##  #               ##  ## #            ### #  ##                   
3HHR_A         9 LFDNAMLRAHRLHQLAFDTYQEFEEAYIpKEQKYSFLQNPqtSLCFSESIPTPSN-REETQQKSNLELLRISLLLIQSWL 87  human
Q01282        26 LFSIAVSRVQHLHLLAQRLFSDFESSLQtEEQRQLNKIFLq-DFCNSDYIISPID-KHETQRSSVLKLLSISYRLVESWE 103 southern black ...
P22077        35 LFTNAVLRAQHLHLLAAETYKEFERTYIpEDQRYTNKNSQa-AFCYSETIPAPTG-KDDAQQKSDMELLRFSLVLIQSWL 112 turkey
P26773         9 LFTNAVLRAQYLHQLAADIYKDFERTYMpNEQRHSSKNSPs-AFCYSETIPAPTG-KDEAQQRSDVELLQFSLALIQSWI 86  Russian sturgeon
P08899        28 LFTSAVNRAQHLHTLAAEIYKEFERSIPpEAHRQLSKTSPl-AGCYSDSIPTPTG-KDETQEKSDGYLLRISSALIQSWV 105 Japanese eel
ACN29925      35 LYDYAMIRAYRLNQLAFDIYQKFEEARSpKEQKDFLQHKArtSLCFSASVPTPTN-RKETLQQSNVELLRNSLLLIQLWF 113 brown-headed sp...
ACM43287      25 RFSIAVSKVQHLHLLAQKYFSDFENSLQtEDQRQFNKFHQ--DFCNPDNIIIPDN-KHETQRSSVLNLLLISKRLVDSWE 101 tongue sole
XP_002748160   1 MGLHVPVDIGGRMVGDTESYMELRDPPPfPPGSSSLVVLEgaGACLENSPQPSALpADDESGVLNLELLRISLLLSQLWL 80  white-tufted-ea...
P10813        34 LFTNAVIRAQHLHQMVADTYRDYERTYIpEDQRFSNKHSYs-VYCYSETIPAPTD-KDNTHQKSDIDLLRFSLTLLQSWM 111 bullfrog
O73848        32 LLSNAVQRANYLHNLAGDRYRDFEQNYIsDEQRHSIKNSPa-AYCYSESSPAPTG-KEDARQKSDMDLLRFSLSLIQAWI 109 Protopterus ann...
P01248        35 LFANAVLRAQHLHQLAADTYKEFERAYIpEGQRYSIQNAQa-AFCFSETIPAPTG-KDEAQQRSDVELLRFSLLLIQSWL 112 pig

Feature 1                                    #  ##  #                                            
3HHR_A        88 EPVQFLRsvfanslvygASDSNVYDLLKDLEEGIQTLMGRLEDg------------------------------------ 131 human
Q01282       104 FPSRSLAgg-------sAPRNQISPKLSELKTGIHLLIRANEDgae---------------------------------- 142 southern black ...
P22077       113 TPMQYLSkvftn-nlvfGTSDRVFEKLKDLEEGIQALMRELEDr------------------------------------ 155 turkey
P26773        87 SPLQSLSrvftn-slvfLTSDRVFEKLKDLEEGIVALMRDLGEg------------------------------------ 129 Russian sturgeon
P08899       106 YPLKTLSdafsn-slmfGTSDGIFDKLEDLNKGINELMKVVGDg------------------------------------ 148 Japanese eel
ACN29925     114 KPVQVFSsvfansqlhgVSHSFIYEYLKDLEEVIQTLIGVRVApevpnpgaplasragrkkhccslfssqaliqetsays 193 brown-headed sp...
ACM43287     102 FSIHFITwn-------lFPRNQVLHRLSDLKKGIQMLIEASDGae----------------------------------- 139 tongue sole
XP_002748160  81 KPVKFLNsvftnsqlhsISNTDIYEYLKDLEEGIQTLTGRLEDg------------------------------------ 124 white-tufted-ea...
P10813       112 TPIQIVNrvfgn-nqvfGNIDRVYDRLRDLDEGLHILIRELDDg------------------------------------ 154 bullfrog
O73848       110 SPLQILGr--------pFGSPDAYDKLLDLEKGLQVLMRELEDg------------------------------------ 145 Protopterus ann...
P01248       113 GPVQFLSrvftn-slvfGTSDRVYEKLKDLEEGIQALMRELEDg------------------------------------ 155 pig

Feature 1                                                                 #  ##  ## ##  ##  #    
3HHR_A       132 -------------------------sPRTGQIFKQTYSKFDtnshndDALLKNYGLLYCFRKDMDKVETFLRIVQCRSv- 185 human
Q01282       143 ------------------------lfPDSSALQLAPYGDYYhspgtdESLRRTYELLACFKKDMHKVETYLTVAKCRLsp 198 southern black ...
P22077       156 -------------------------sPRGPQLLRPTYDRFDihlrseDALLKNYGLLSCFKKDLHKVETYLKVMKCRRfg 210 turkey
P26773       130 -------------------------gFGSSTLLKLTYDKFDvnlrndDALFKNYGLLSCFKKDMHKVETYLKVMKCRRfv 184 Russian sturgeon
P08899       149 -------------------------gIYIEDVRNLRYENFDvhlrndAGLMKNYGLLACFKKDMHKVETYLKVTKCRRfv 203 Japanese eel
ACN29925     194 sfplvnppglslhhgalekreekervREGGNSVQALASPSLpslcrgWKMAAPGLGTSSGRPTASLTQTCTRMTHCSRtt 273 brown-headed sp...
ACM43287     140 -------------------------mSDSITLPVTPFGNFYenlggnESQKRNYELLACFKKDMHKVETYLTVAKCRLsp 194 tongue sole
XP_002748160 125 -------------------------sPRTGEIFRQTYSKFD------RNSHNDDTLLHCFRKDIDKVEKFLCIVQCHSv- 172 white-tufted-ea...
P10813       155 -------------------------nVRNYGVLTFTYDKFDvnlrseEGRAKNYGLLSCFKKDMHKVETYLKVMKCRRfv 209 bullfrog
O73848       146 -------------------------sSRGLSLLKHTYDKFSanqfseEATLKNYSLLACFKKDMHKVETYLRVMKCRRfp 200 Protopterus ann...
P01248       156 -------------------------sPRAGQILKQTYDKFDtnlrsdDALLKNYGLLSCFKKDLHKAETYLRVMKCRRfv 210 pig

Feature 1                        #
3HHR_A       186 -------------eGSC 189 human
Q01282       199 -------------eANC 202 southern black bream
P22077       211 -------------eSNC 214 turkey
P26773       185 -------------eSNC 188 Russian sturgeon
P08899       204 -------------eSNC 207 Japanese eel
ACN29925     274 rcciasgetwtrsrHSC 290 brown-headed spider monkey
ACM43287     195 -------------eANC 198 tongue sole
XP_002748160 173 -------------eGSC 176 white-tufted-ear marmoset
P10813       210 -------------eSNC 213 bullfrog
O73848       201 -------------eSNC 204 Protopterus annectens
P01248       211 -------------eSSC 214 pig

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