3H1Z


Conserved Protein Domain Family
B2-adapt-app_C
?
smart01020: B2-adapt-app_C 
Click on image for an interactive view with Cn3D
Beta2-adaptin appendage, C-terminal sub-domain
Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
Links
?
Statistics
?
PSSM-Id: 198088
Aligned: 20 rows
Threshold Bit Score: 85.438
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3H1Z_A       149 FVEdgKME--RQVFLATW-KDIPNENELQFQIKE----C---HL----NADTVSSKLQNNNVYTIAKRNVEGQ--DMLYQ 212  Norway rat
XP_002715802 592 LVPdcQLT--AEYFEKTW-LSLQVAHQQVLPWQG----A----V----HPDTFQMALQVVNIQTIAMSRAGAQp-WKAYL 655  rabbit
NP_001190701 804 FGEdgRME--RGTFLETW-RSLPDSNEVLKEFPG----I---TIt---SVESTIELLTAFNMFFIAKRKNGNQ--DVIYL 868  thale cress
NP_001101179 620 LVPnlQLT--AECFEKTW-LSLTVSYHQVLPWQG----E----V----QPDTLQMALKVVNIQTIAMSKPGAQp-WKAYL 683  Norway rat
XP_641846    827 LTEtgRLD--RESYLSMW-KSIPESNERSVEIQV----Rl-pHV----DVDSILRRLNSKNIFEIVRKKAPNQ--EISFL 892  Dictyostelium ...
NP_196710    721 lnaraaLD--PGAFQQKW-RQLPISLTQECSVNPqgiaA---LT----VPQSLIKHMQSHSIHCIASGGQSPNf-KFFFF 789  thale cress
XP_001349197 741 iidvdSIN--PEVYQTQW-NALPEQNNEKIFLRK----Ny-yNL----QLDTIDQLISKYNLITLASGEIDQC--LKFYM 806  Plasmodium fal...
XP_823147    654 LSVdaSME--LHEFEHRW-ISLGDSVVTTANMQL----RlrsVP----DMEMFEDALDVCGVVMLTAGPHNDG--DRCFL 720  Trypanosoma br...
XP_764870    776 FKHeaKVS--RSDFESLWvRLQPKDFNHNYYYKY----S---NPrntdANRGIVKALQSYGLYHVGVGLCGDRgsDSDFF 846  Theileria parv...
XP_639163    703 FILdqQPElsPELFQSLW-LSLEDGHKIDIQL-D----S---PI----DNSEIESVMSKQGIICLAFGSVDQQ--TKLYY 767  Dictyostelium ...

3H1Z_A       213 SLKLTNGI---------------WILAELrIQPGNPNYTLSLKCRA--PEVSQYIYQVYDSILK 259  Norway rat
XP_002715802 656 SAQDDTGC---------------LFLTELlLEPKTSEMQVSVKQSEarTETLNSFMSVLETVIG 704  rabbit
NP_001190701 869 SAKDPRDV---------------PFLIELtAMVGQPGLKCAVKTPT--PEIAPLFFEALELLFK 915  thale cress
NP_001101179 684 SAQDGTGG---------------LFLTELlLKPENSEVQISVKQSEarTEALRGFVSVLETVIG 732  Norway rat
XP_641846    893 SCKTESSV---------------YILIELaFNISTNTCRCSSKTTS--PDIMALFEHNLNLLIN 939  Dictyostelium discoideum AX4
NP_196710    790 AQKESEPS---------------NYLTECiINTSSAKAQIKVKADE--QSTCQAFTTVFETALS 836  thale cress
XP_001349197 807 YSQLYTKH---------------YIFIELiFNKRDNSINWIFKSECndENLIEQFTDCFRDIFl 855  Plasmodium falciparum 3D7
XP_823147    721 YAQEEGAMg-------------aYFLLEVcLSRNGM-VNVKVKSDS---AHMQQFLQHFHKIMD 767  Trypanosoma brucei TREU927
XP_764870    847 YALTTNSL---------------AILTKFtRD------TFTVKCES--STVLMLFAKAVEKMLS 887  Theileria parva strain Muguga
XP_639163    768 YARQNLSFdidfnseqnqqqpqpIFIIEIlIDENTLLMSILFK--S--PILKTLHNKFIPKFLS 827  Dictyostelium discoideum AX4
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap