1TCF,1SMG,1AJ4,1AJ4,1OZO,1CB1,1KSM,1XK4,1A03,1LA3,1DJG,2L2E,3I5G,3I5G,3I5G,3JTD,3FWB,3FWB,3FWB,2AMI,1ZMZ,1LKJ,1GGZ,2NXQ,3LI6


Conserved Protein Domain Family
EFh
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smart00054: EFh 
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EF-hand, calcium binding motif
EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.
Links
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Statistics
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PSSM-Id: 197492
Aligned: 375 rows
Threshold Bit Score: 26.9577
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TCF_A       130 EIESLMKDGDKNNDGRIDFDEFLKMMEGV 158 rabbit
XP_002598456 146 EVEEAMKEADEDGNGVIDIPEFMDLIKks 174 Florida lancelet
NP_593340    122 EVADMIREADTDGDGVINYEEFSRVISSK 150 Schizosaccharomyces pombe 972h-
XP_002622905 155 EVDEMIREADQDGDGRIDYNEFVQLMMQK 183 Ajellomyces dermatitidis SLH14081
XP_641695    123 EVDEMIREADLDGDGQVNYDEFVKMMIVR 151 Dictyostelium discoideum AX4
ABA01113     124 EVDEMIREADVDGDGQVNYEEFVRMMTSG 152 Chlamydomonas incerta
XP_001118652 460 EVDEMIRAADTDGDGQVNYEEFVRVLVSK 488 rhesus monkey
XP_003114118 170 EVDEMIKEVDVDGDGEIDYEEFVKMMSNQ 198 Caenorhabditis remanei
AAB03218     121 EISEMIREADIDGDGMVNYEEFVKMMTPK 149 Doryteuthis pealeii
XP_002041300 120 EIDEMIREADFDGDGMINYEEFVWMISQK 148 Drosophila sechellia
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