1CX8,1DE4


Conserved Protein Domain Family
M28_TfR
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cd09848: M28_TfR (this model, PSSM-Id:193572 is obsolete and has been replaced by 349946)
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M28 Zn-peptidase Transferrin Receptor family
Peptidase M28 family; Transferrin Receptor (TfR) subfamily. TfRs are homodimeric type II transmembrane proteins containing three distinct domains: protease-like, apical or protease-associated (PA), and helical domains. The protease-like domain is a large extracellular portion (ectodomain). In TfR, it contains a binding site for the transferrin molecule and has 28% identity to membrane glutamate carboxypeptidase II (mGCP-II or PSMA). The PA domain is inserted between the first and second strands of the central beta sheet in the protease-like domain. TfR1 is widely expressed, and is a key player in the uptake of iron-loaded transferrin (Tf) into cells. The TfR1 homodimer binds two molecules of Tf and the complex is then internalized. TfR1 may also participate in cell growth and proliferation. TfR2 binds Tf but with a significantly lower affinity than TfR1. It is expressed chiefly in hepatocytes, hematopoietic cells, and duodenal crypt cells; its expression overlaps with that of hereditary hemochromatosis protein (HFE). TfR2 is involved in iron homeostasis; in humans, mutations in TfR2 are associated with a form of hemochromatosis (HFE3). While related in sequence to peptidase M28 glutamate carboxypeptidase II (also called prostate-specific membrane antigen or PSMA), TfR lacks the metal ion coordination centers and protease activity of that group.
Links
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Statistics
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PSSM-Id: 193572
Aligned: 9 rows
Threshold Bit Score: 388.687
Created: 11-Feb-2011
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:TfR is a homodimeric type II transmembrane protein.
  • Structure:1DE4_C; Human transferrin receptor (TfR) forms a homodimer; contacts at 4A.
    - View structure with Cn3D
  • Structure:1CX8_A; Human transferrin receptor ectodomain forms a homodimer; contacts at 4A.
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          # ## #                     
1CX8_A      6 LKRKLSEKldstDFTSTIKLLNensyvPREAGsqkDENLALYVENEFREFklsKVWRDQHFvkiqvkdsaqnsviivdkn 85  human
1DE4_C      7 LKRKLSEKldstDFTSTIKLLNensyvPREAGsqkDENLALYVENQFREFklsKVWRDQHFvkiqvkdsaqnsviivdkn 86  human
Q90997    139 LKAMLSKKlsakNLVDNLRWRVgv--dSFEAGeaeDTNMATYIHEEFRNFl-dKVWNDEHYiklqvrgstknqvsising 215 chicken
Q9UP52    144 FLQFLGEG----RLEDTIRQTSl---rERVAGsagMAALTQDIRAALSRQkldHVWTDTHYvglqfpdpahpntlhwvde 216 human
CAF97624  124 LNAKVSKD----NFEMLFADLSs---sSHQAGspgDETLANKVLSKFKDYg-mKTWSDEHFvkvqdpprsgfnsivfkdg 195 Tetraodon nigrovir...
AAV66588  134 LKRKLTTE----NINSNFKEFSs---lSHQAGssgDEMLANKIMGKFKTLg-mNPWTDEHYvkvhdpgasnnrvlfrnnv 205 zebrafish
AAV66589  144 LNDKLSSK----SIEEQLSVYSq---iGRSAGssvDNKLGDTIHDAFTKLn-mEPWVDEHYvklqnpdssnpnkvwfgne 215 zebrafish
AAV66590  131 LKKYLKEE----RIENTLRRVSr---eSHPPGsseGNAIAREILQNLQNLgmdHTWTDSHYatlqfpsrthrntlwlvds 203 zebrafish
CBN82172  139 LTQKLTSQ----AFDQTLRDFDl---pKRSAGseeDMKLANLMFDEFKTLe-mDPWTDIHYiqlqtpdserpnrilfgsd 210 European seabass

Feature 1                                                                                     
1CX8_A     86 grlvylvenpggyvayskaatvtgklvhanfgtkkdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqt 165 human
1DE4_C     87 grlvylvenpggyvayskaatvtgklvhanfgtkkdfedlytpvngsivivragkitfaekvanaeslnaigvliymdqt 166 human
Q90997    216 keeiletpdaivaysesgsvsgkpvyvnyglkkdfeiiqkvvaslngtivivragkitlaekvanakeagaagvlmyvds 295 chicken
Q9UP52    217 agkvgeqlpledpdvycpysaignvtgelvyahygrpedlqdlrargvdpvgrlllvrvgvisfaqkvtnaqdfgaqgvl 296 human
CAF97624  196 neerpsgflsysacgrvmgavlyghygqesdlmmlqnknldlsgrvlllragrnsfaekvanaaklnasavliypdp--- 272 Tetraodon nigrovir...
AAV66588  206 vgttegylaysaiktvqgaalyahygraedfrrlqevsadvsekvvlvragllsyaekvanaaslnasavliypdpvnyq 285 zebrafish
AAV66589  216 eigspkgflaysetgrregrvvyanygepadlqavqanevslngtvvlmragrismaqkvmnvaklgavaaliypdpa-- 293 zebrafish
AAV66590  204 egaeleeirldsegycaysatgtatgglvyvnygrredfdqlrvmgvslngsiamvrvgggvsfaekvwlaqeaghvgvl 283 zebrafish
CBN82172  211 dfkptgylaysatgevqgklvygnygrqedldvlqknsielkgsvlllragsisfaeqvdnvatkgasavliypdvkdy- 289 European seabass

Feature 1                                                                                     
1CX8_A    166 --------------------kfpivnaelsffghahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklf 225 human
1DE4_C    167 --------------------kfpivnaelsffghahlgtgdpytpgfpsfnhtqfppsrssglpnipvqtisraaaeklf 226 human
Q90997    296 lm----------------ygitdtlipfghahlgtgdpytpgfpsfnhtqfppvessglphiavqtisssaaarlfskmd 359 chicken
Q9UP52    297 iypepad------fsqdppkpslssqqavyghvhlgtgdpytpgfpsfnqtqfppvassglpsipaqpisadiasrllrk 370 human
CAF97624  273 ----------------------adyalqdttelfghvhlgsgdpytpgfpsfnhtqfppvvssglpkipaqtitagmask 330 Tetraodon nigrovir...
AAV66588  286 --------------------ikentalfghvhlgtgdpytpgfpsfnhtqfppaqssglpsipaqtittkqaseimsklg 345 zebrafish
AAV66589  294 ---------------------dydgmdtelyghvhlgsgdpytpgfpsfnhtqfapakssglpeilaqtipasmarkils 352 zebrafish
AAV66590  284 iypdpadvpqdprrlglhsnavisehvhlgsgdpftpgfpsfnhtqfpstqssglpiipaqpisanvaakllsqlsgavc 363 zebrafish
CBN82172  290 ---------------------dyvadtalyghvhlgsgdpytpgfpsfnhtqfpptrssglpkipaqtitakmatallqk 348 European seabass

Feature 1                                                  # #  # ## #                        
1CX8_A    226 gnmegdcpsdwktdstcrmvtsesknvkltvsnvlkeiKILNIFGVIKGfVEPDHYVVVGAQRDAWgpGAAKSGVGTALL 305 human
1DE4_C    227 gnmegdcpsdwktdstcrmvtsesknvkltvsnvlkeiKILNIFGVIKGfVEPDHYVVVGAQRDAWgpGAAKSGVGTALL 306 human
Q90997    360 gdtcsegwkgaihsckvttkqesqimvkldvnnsmkdrKILNIFGAIQGfEEPDRYVVIGAQRDSWgpGVAKAGTGTAIL 439 chicken
Q9UP52    371 lkgpvapqewqgsllgspyhlgpgprlrlvvnnhrtstPINNIFGCIEGrSEPDHYVVIGAQRDAWgpGAAKSAVGTAIL 450 human
CAF97624  331 ilrqlggpvvpagwtgalrlgdekdiitmevsnvltekKISNVFGVIKGiVDSDRYLVIGAQRDAWgsGFAKSTVGTSVL 410 Tetraodon nigrovir...
AAV66588  346 grssprewsdgmladtqyllgdkddiitvevnnvlvqkKIHNVFGVIKGyLDADRYLVIGVQRDAWgpGFARSTVGTSLL 425 zebrafish
AAV66589  353 kmggsevpskfkggftsykfgdesnkvalsinnklvdtKIHNVFGVIKGyVDPDRYVVIGAQRDSMtsGYAKSAVGTTLL 432 zebrafish
AAV66590  364 prgwqgrlpyvqcvlgpgfsgvgvrqlkmavynsmkpvLLNNIFASIEGkVEPDHYIIIGAQRDAWgpGAVKSGVGTALL 443 zebrafish
CBN82172  349 iggpeasggflgglksvtyrlggsenitvevnnvlvnrEIHNVFGVIKGfTDPDRYVVLGAQRDAWdrGYAKAAVGTSVL 428 European seabass

Feature 1                         # #                #  #########                             
1CX8_A    306 LKLAQMFSDMVLKdGFQPsRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGtSNFKVSASPLLYTLI 385 human
1DE4_C    307 LKLAQMFSDMVLKdGFQPsRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGtSNFKVSASPLLYTLI 386 human
Q90997    440 LELARVISDIVKNeGYKPrRSIIFASWSAGDYGAVGATEWLEGYSAMLHAKAFTYISLDAPVLGaSHVKISASPLLYMLL 519 chicken
Q9UP52    451 LELVRTFSSMVSN-GFRPrRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGdDKFHAKTSPLLTSLI 529 human
CAF97624  411 LELARSISEMMKE-GFKPrRSILFASWSAGEYGSVGATEWLEAYLSSLSMKAFSYINLDSVIAGqSGFKVAASPLMHSVV 489 Tetraodon nigrovir...
AAV66588  426 VELARTITDMIKNdGFKPkRSIVFASWSAGEFGGVGATEWLEGYLNSLNLKMFSYISLDDLISGsDSFKAAASPLLYDLL 505 zebrafish
AAV66589  433 MELARVFNELKKE-GFKPkRSIVFASWTAGDFGKVGATEWLEGYWASLDRKAFTYISLDGVVSGkDSLRASASPLLHTLL 511 zebrafish
AAV66590  444 MELARTFSNMVEN-GFSPrRSLLFVSWDGGEFGNVGATEWLEGYLTMLHLKAVAYFSLDQAILGdDVLSVYSSPLLSHLI 522 zebrafish
CBN82172  429 VQLARAVHEMVENdGFRPrRSLVFASWSAGEYGSVGATEWLEGYMSSIDKRVITYISLDGMVMGhGSFMASASPLLHRLL 508 European seabass

Feature 1                                                                                     
1CX8_A    386 EKTMQNVKHPvtgqfly-------qdsnwasKVEKLTlDNAAFPFLAYSGIPAVSFCFCEdt---dYPYLGTTMDTYKEL 455 human
1DE4_C    387 EKTMQNVKHPvtgqfly-------qdsnwasKVEKLTlDNAAFPFLAYSGIPAVSFCFCEdt---dYPYLGTTMDTYKEL 456 human
Q90997    520 GSIMKGVKNPaavseslyn----rlgpdwvkAVVPLGlDNAAFPFLAYSGIPVLSFGFYNkd--eeYRFLDTKGDTLENL 593 chicken
Q9UP52    530 ESVLKQVDSPnhsgqtlyeqvvftnpswdaeVIRPLPmDSSAYSFTAFVGVPAVEFSFMEdd--qaYPFLHTKEDTYENL 607 human
CAF97624  490 VGALKEVHYSnpdrtlydr---ftrsnwesdILEPLKlDNAAYPFLAFSGIPSVSFGFTSgy--keYPYFGTLLDTKDSL 564 Tetraodon nigrovir...
AAV66588  506 ESTMKQVSSPtdstkslheq--fagsnweksVIEPMGlSHPSYAFQTFSGIPSLSFRFFTns---rFYPFGTFEDTNQNL 580 zebrafish
AAV66589  512 QKTLEKVKAPmlsyg-----------sdfssILTNMQmDDGAYPFLTFSGIPSVSFSFISsrttpdYKYFGTEMDTKERL 580 zebrafish
AAV66590  523 EGAIKQVEHPkhtgqsilsl--vqrqggwrnIVKPLYlNSGAYSFTAFGGVPAMQLHFTEdx--rsYPFVNTQLDSVGRL 598 zebrafish
CBN82172  509 ERTMKAVKSPvgsdtiynm---mgksnweanTLRPMSmDDPAYPFLAFSGIPSISFHFISpns-etYAYYGTSLDNKDHL 584 European seabass

Feature 1                                        
1CX8_A    456 IERIp-eLNKVARAAAEVAGQFVIKLTHDVELNLD 489 human
1DE4_C    457 IERIp-eLNKVARAAAEVAGQFVIKLTHDVELNLD 490 human
Q90997    594 RKIDn--LDALLAAAAEVAGQAALRLTHDHELFLD 626 chicken
Q9UP52    608 HKVLqgrLPAVAQAVAQLAGQLLIRLSHDRLLPLD 642 human
CAF97624  565 EKATnnqVHHLAQTVTRFAGHMALRLVHDHLLRVD 599 Tetraodon nigroviridis
AAV66588  581 DLFTsrkTLVLAKAAGEVAGLVTLRLVHDHLLKLN 615 zebrafish
AAV66589  581 DSVTgqqVVELSMLAAQVAGQMALRLVHDQILRLD 615 zebrafish
AAV66590  599 QELLqgrLGSVGRAVGELVGLMVLKLAHDHILPLD 633 zebrafish
CBN82172  585 NYQTnhrTSEVTAVAAQFAGQMALRLIHDHVLNLD 619 European seabass

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