CCDS Report for Consensus CDS

Collaborators
EBI
HGNC
MGI
NCBI

Genome Displays

Interpretation	Date	Source	Comment	Data
CCDS: Made public	04/30/2008	NCBI		CCDS Release: 5
CCDS: Public note	03/03/2009	NCBI	This CCDS ID was withdrawn because the genome contains a 1 nt insertion and cannot represent the updated protein. The genome contains an extra 'C' at codon 424, which results in a frameshift and a protein with a different C-terminus compared to that encoded by AF193807.1, AY139092.1 and AY139093.1. Experimental evidence in PMID:18635543 indicates that residues downstream of aa 424 are important for phosphorylation of the 458 aa protein represented by the update, and this phosphorylation regulates both C-terminal anchorage to the membrane skeleton and the ammonium transport activity of the protein. The updated protein is supported by homologs in several mammalian species, including mouse NP_067350.2 (CCDS17466.1), rat NP_898877.1, dog NP_001003017.2, and pig NP_999161.1. It is possible that the additional 'C' in the reference genome sequence represents a valid polymorphism, but currently the representative SNPs (rs11303415 and rs60769529) have not been validated and no population diversity data exist for them.	CCDS version: 41414.1
CCDS: Withdrawn	09/02/2009	NCBI
CCDS: Reinstated	08/11/2016	NCBI		CCDS Release: 20
CCDS: Updated	08/11/2016	NCBI		CCDS Release: 20
CCDS: Review status	10/03/2016	NCBI		by RefSeq, Havana and CCDS collaboration
CCDS: Retained	05/16/2018	NCBI		CCDS Release: 22
CCDS: Retained	08/10/2022	NCBI		CCDS Release: 24

	Links Key
	Links to:	History report BLAST report Entrez Gene Nucleotide report Protein report
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