6S7O: Cryo-EM structure of human oligosaccharyltransferase complex OST-A

PDB ID: 6S7ODownload
MMDB ID: 182410
PDB Deposition Date: 2019/7/5
Updated in MMDB: 2019/12
Experimental Method:
electron microscopy
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6S7O: octameric; determined by author and by software (PISA)
Molecular Components in 6S7O
Label Count Molecule
Proteins (8 molecules)
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit Stt3a
(Gene symbol: STT3A)
Molecule annotation
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit 4
(Gene symbol: OST4)
Molecule annotation
1
Transmembrane Protein 258
(Gene symbol: TMEM258)
Molecule annotation
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit Dad1
(Gene symbol: DAD1)
Molecule annotation
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit 1
(Gene symbol: RPN1)
Molecule annotation
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Subunit 2
(Gene symbol: RPN2)
Molecule annotation
1
Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase 48 KDA Subunit
Molecule annotation
1
Oligosaccharyltransferase Complex Subunit Ostc
(Gene symbol: OSTC)
Molecule annotation
Chemicals and Non-standard biopolymers (38 molecules)
1
6
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
3
BETA-D-MANNOSEBETA-D-MANNOSE
3
10
ALPHA-D-MANNOSEALPHA-D-MANNOSE
4
9
(2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol(2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol
5
7
(4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium(4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium
6
2
MAGNESIUM IONMAGNESIUM ION
7
1
[(3~{R},6~{Z},10~{Z},14~{Z},18~{Z})-3,7,11,15,19,23-hexamethyltetracosa-6,10,14,18,22-pentaenyl] dihydrogen phosphate[(3~{R},6~{Z},10~{Z},14~{Z},18~{Z})-3,7,11,15,19,23-hexamethyltetracosa-6,10,14,18,22-pentaenyl] dihydrogen phosphate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303