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    Cnnm1 cyclin M1 [ Mus musculus (house mouse) ]

    Gene ID: 83674, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cnnm1provided by MGI
    Official Full Name
    cyclin M1provided by MGI
    Primary source
    MGI:MGI:1891366
    See related
    Ensembl:ENSMUSG00000025189 AllianceGenome:MGI:1891366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acdp1; CLP-1
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to act upstream of or within ion transport. Located in dendrite; neuronal cell body; and plasma membrane. Orthologous to human CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 15.2), cortex adult (RPKM 9.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 36.67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43427508..43485649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43439069..43497210)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heparanase 2 Neighboring gene leucine zipper transcription factor-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46194 Neighboring gene predicted gene, 38568 Neighboring gene STARR-seq mESC enhancer starr_46196 Neighboring gene STARR-positive B cell enhancer mm9_chr19:43592413-43592714 Neighboring gene STARR-positive B cell enhancer ABC_E1525 Neighboring gene STARR-positive B cell enhancer ABC_E1213 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene glutamic-oxaloacetic transaminase 1, soluble

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis. Chandran U, et al. Biol Reprod, 2016 Jul. PMID 27251091
    2. Ancient conserved domain protein-1 binds copper and modifies its retention in cells. Alderton A, et al. J Neurochem, 2007 Oct. PMID 17608643
    3. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. Guo D, et al. Mol Pain, 2005 Apr 19. PMID 15840172, Free PMC Article
    4. Molecular cloning and characterization of the mouse Acdp gene family. Wang CY, et al. BMC Genomics, 2004 Jan 15. PMID 14723793, Free PMC Article
    5. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. Kasowitz SD, et al. PLoS Genet, 2018 May. PMID 29799838, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNNM1 expression was restricted to c-KIT- and OCT3/4-positive cells in the testis, indicating that they are early spermatogonial cells. Spermatogonial stem cells in primary culture expressed Cnnm1, and their differentiation into embryoid body-like clusters in vitro resulted in the loss of Cnnm1 expression. Silencing of Cnnm1 in GC1-spg cells reduced number of cells in G1 phase with increased cells in S and G2/M phases.
      Title: Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis.
    2. We determined that ACDP-1 is a high affinity copper binding protein able to bind copper at nanomolar concentrations. In addition the promoter of ACDP-1 contains metal response elements and cellular expression of ACDP-1 alters cellular retention of copper.
      Title: Ancient conserved domain protein-1 binds copper and modifies its retention in cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metal transporter CNNM1
    Names
    ancient conserved domain protein 1
    ancient conserved domain-containing protein 1
    cyclin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373992.1 → NP_001360921.1  metal transporter CNNM1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140375
      Consensus CDS
      CCDS89394.1
      UniProtKB/TrEMBL
      A0A286YDL2
      Related
      ENSMUSP00000153472.2, ENSMUST00000223787.2
      Conserved Domains (1) summary
      COG1253
      Location:251 → 553
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    2. NM_001424972.1 → NP_001411901.1  metal transporter CNNM1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140375

    3. NM_031396.3 → NP_113573.2  metal transporter CNNM1 isoform 2

      See identical proteins and their annotated locations for NP_113573.2

      Status: VALIDATED

      Source sequence(s)
      AC140375, AF202994, EF041508
      Consensus CDS
      CCDS50442.1
      UniProtKB/Swiss-Prot
      Q0GA42, Q9JIQ6
      Related
      ENSMUSP00000131830.2, ENSMUST00000165311.3
      Conserved Domains (1) summary
      COG1253
      Location:251 → 553
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43427508..43485649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527480.5 → XP_006527543.1  metal transporter CNNM1 isoform X1

      Conserved Domains (1) summary
      COG1253
      Location:251 → 553
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    2. XM_006527482.5 → XP_006527545.1  metal transporter CNNM1 isoform X2

      Conserved Domains (1) summary
      COG1253
      Location:251 → 553
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    3. XM_036161732.1 → XP_036017625.1  metal transporter CNNM1 isoform X3

      Conserved Domains (1) summary
      COG1253
      Location:251 → 553
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    RNA

    1. XR_004940187.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0GA42.5 GenPept UniProtKB/Swiss-Prot:Q0GA42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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