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    ZNF329 zinc finger protein 329 [ Homo sapiens (human) ]

    Gene ID: 79673, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF329provided by HGNC
    Official Full Name
    zinc finger protein 329provided by HGNC
    Primary source
    HGNC:HGNC:14209
    See related
    Ensembl:ENSG00000181894 AllianceGenome:HGNC:14209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), thyroid (RPKM 3.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58126248..58155104, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61222728..61251579, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58637615..58662156, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15178 Neighboring gene uncharacterized LOC124904784 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694039-58694752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694753-58695464 Neighboring gene zinc finger protein 274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reconstructing directed gene regulatory network by only gene expression data. Zhang L, et al. BMC Genomics, 2016 Aug 18. PMID 27556418, Free PMC Article
    2. USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer. Ren Y, et al. Cancer Res, 2023 Apr 4. PMID 36607699
    3. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
    4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    5. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Lee SH, et al. Mol Cell, 2019 May 16. PMID 30948266, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12586

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 329

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024620.4 → NP_078896.3  zinc finger protein 329

      See identical proteins and their annotated locations for NP_078896.3

      Status: VALIDATED

      Source sequence(s)
      AC008751, AK095349, BC047501
      Consensus CDS
      CCDS12972.1
      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Related
      ENSP00000470008.1, ENST00000598312.6
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58126248..58155104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723384.4 → XP_006723447.1  zinc finger protein 329 isoform X2

      See identical proteins and their annotated locations for XP_006723447.1

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    2. XM_011527313.3 → XP_011525615.1  zinc finger protein 329 isoform X1

      See identical proteins and their annotated locations for XP_011525615.1

      Conserved Domains (5) summary
      COG5048
      Location:200 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:480 → 547
      DUF45; Protein of unknown function DUF45

    3. XM_011527310.3 → XP_011525612.1  zinc finger protein 329 isoform X1

      See identical proteins and their annotated locations for XP_011525612.1

      Conserved Domains (5) summary
      COG5048
      Location:200 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:480 → 547
      DUF45; Protein of unknown function DUF45

    4. XM_006723383.4 → XP_006723446.1  zinc finger protein 329 isoform X2

      See identical proteins and their annotated locations for XP_006723446.1

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    5. XM_011527311.3 → XP_011525613.1  zinc finger protein 329 isoform X1

      See identical proteins and their annotated locations for XP_011525613.1

      Conserved Domains (5) summary
      COG5048
      Location:200 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:480 → 547
      DUF45; Protein of unknown function DUF45

    6. XM_047439443.1 → XP_047295399.1  zinc finger protein 329 isoform X1

    7. XM_011527314.3 → XP_011525616.1  zinc finger protein 329 isoform X1

      See identical proteins and their annotated locations for XP_011525616.1

      Conserved Domains (5) summary
      COG5048
      Location:200 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:480 → 547
      DUF45; Protein of unknown function DUF45

    8. XM_011527316.3 → XP_011525618.1  zinc finger protein 329 isoform X2

      See identical proteins and their annotated locations for XP_011525618.1

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    9. XM_006723381.3 → XP_006723444.1  zinc finger protein 329 isoform X2

      See identical proteins and their annotated locations for XP_006723444.1

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Related
      ENSP00000350773.4, ENST00000358067.5
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    10. XM_011527312.3 → XP_011525614.1  zinc finger protein 329 isoform X1

      See identical proteins and their annotated locations for XP_011525614.1

      Conserved Domains (5) summary
      COG5048
      Location:200 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:380 → 405
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:480 → 547
      DUF45; Protein of unknown function DUF45

    11. XM_006723382.4 → XP_006723445.1  zinc finger protein 329 isoform X2

      See identical proteins and their annotated locations for XP_006723445.1

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
      Conserved Domains (5) summary
      COG5048
      Location:177 → 539
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:203 → 225
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:457 → 524
      DUF45; Protein of unknown function DUF45

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61222728..61251579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322161.1 → XP_054178136.1  zinc finger protein 329 isoform X1

    2. XM_054322168.1 → XP_054178143.1  zinc finger protein 329 isoform X2

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7

    3. XM_054322162.1 → XP_054178137.1  zinc finger protein 329 isoform X1

    4. XM_054322167.1 → XP_054178142.1  zinc finger protein 329 isoform X2

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7

    5. XM_054322160.1 → XP_054178135.1  zinc finger protein 329 isoform X1

    6. XM_054322158.1 → XP_054178133.1  zinc finger protein 329 isoform X1

    7. XM_054322163.1 → XP_054178138.1  zinc finger protein 329 isoform X1

    8. XM_054322159.1 → XP_054178134.1  zinc finger protein 329 isoform X1

    9. XM_054322164.1 → XP_054178139.1  zinc finger protein 329 isoform X2

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7

    10. XM_054322165.1 → XP_054178140.1  zinc finger protein 329 isoform X2

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7

    11. XM_054322166.1 → XP_054178141.1  zinc finger protein 329 isoform X2

      UniProtKB/Swiss-Prot
      B3KR32, Q86UD4, Q9H9R7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UD4.2 GenPept UniProtKB/Swiss-Prot:Q86UD4

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