U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ninl ninein-like [ Mus musculus (house mouse) ]

    Gene ID: 78177, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ninlprovided by MGI
    Official Full Name
    ninein-likeprovided by MGI
    Primary source
    MGI:MGI:1925427
    See related
    Ensembl:ENSMUSG00000068115 AllianceGenome:MGI:1925427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1004; Gm1634; mKIAA0980; 4930519N13Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Predicted to be located in cytosol; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in centrosome. Is expressed in liver left lobe and liver right lobe. Orthologous to human NINL (ninein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 7.2), CNS E11.5 (RPKM 6.5) and 20 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2 G3; 2 74.76 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150776439..150851330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150934519..151009411, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 1 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3410 Neighboring gene N-acetylneuraminic acid phosphatase Neighboring gene STARR-seq mESC enhancer starr_06026 Neighboring gene predicted gene, 22187

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. Shao S, et al. J Clin Invest, 2010 Feb. PMID 20093778, Free PMC Article
    2. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ninein-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207204.2 → NP_997087.2  ninein-like protein

      See identical proteins and their annotated locations for NP_997087.2

      Status: VALIDATED

      Source sequence(s)
      BC067071, BU058995, BY302641, BY715392, CO427181
      Consensus CDS
      CCDS50744.1
      UniProtKB/Swiss-Prot
      A2ANB8, Q6NXH6, Q6ZQ12
      Related
      ENSMUSP00000105522.2, ENSMUST00000109896.8
      Conserved Domains (3) summary
      cd00051
      Location:213 → 260
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam10221
      Location:622 → 707
      DUF2151; Cell cycle and development regulator
      pfam13499
      Location:202 → 260
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150776439..150851330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500406.4 → XP_006500469.1  ninein-like protein isoform X1

      Conserved Domains (4) summary
      PRK13589
      Location:305 → 363
      PRK13589; flagellin A
      COG1196
      Location:622 → 1392
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1085 → 1395
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205 → 266
      EF-hand_7; EF-hand domain pair

    2. XM_030252241.1 → XP_030108101.1  ninein-like protein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:85 → 448
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:765 → 1075
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_030252240.1 → XP_030108100.1  ninein-like protein isoform X6

      Conserved Domains (4) summary
      PRK13589
      Location:248 → 306
      PRK13589; flagellin A
      COG1196
      Location:338 → 1336
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1028 → 1338
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:11 → 71
      EF-hand_7; EF-hand domain pair

    4. XM_030252239.2 → XP_030108099.1  ninein-like protein isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:584 → 1354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1047 → 1357
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199 → 260
      EF-hand_7; EF-hand domain pair

    5. XM_030252242.2 → XP_030108102.1  ninein-like protein isoform X8

      Conserved Domains (2) summary
      COG1196
      Location:38 → 401
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:718 → 1028
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_030252243.2 → XP_030108103.1  ninein-like protein isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:12 → 343
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:660 → 970
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_006500407.4 → XP_006500470.1  ninein-like protein isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:590 → 1360
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1053 → 1363
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205 → 266
      EF-hand_7; EF-hand domain pair

    8. XM_006500409.4 → XP_006500472.1  ninein-like protein isoform X5

      Conserved Domains (4) summary
      PRK13589
      Location:254 → 312
      PRK13589; flagellin A
      COG1196
      Location:571 → 1341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1034 → 1344
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:17 → 77
      EF-hand_7; EF-hand domain pair

    9. XM_006500408.4 → XP_006500471.1  ninein-like protein isoform X3

      Conserved Domains (3) summary
      PRK13589
      Location:305 → 363
      PRK13589; flagellin A
      TIGR02168
      Location:437 → 1358
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:205 → 266
      EF-hand_7; EF-hand domain pair

    10. XM_011239847.3 → XP_011238149.1  ninein-like protein isoform X10

      See identical proteins and their annotated locations for XP_011238149.1

      Conserved Domains (1) summary
      TIGR02168
      Location:460 → 770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ12.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous