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    ZNF225 zinc finger protein 225 [ Homo sapiens (human) ]

    Gene ID: 7768, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF225provided by HGNC
    Official Full Name
    zinc finger protein 225provided by HGNC
    Primary source
    HGNC:HGNC:13018
    See related
    Ensembl:ENSG00000256294 AllianceGenome:HGNC:13018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 1.5), testis (RPKM 1.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44111425..44134822)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46934319..46957717)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44617552..44638975)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene zinc finger protein 234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    2. USP45 and Spindly are part of the same complex implicated in cell migration. Conte C, et al. Sci Rep, 2018 Sep 26. PMID 30258100, Free PMC Article
    3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
    5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC119735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 225

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321685.2 → NP_001308614.1  zinc finger protein 225

      Status: VALIDATED

      Source sequence(s)
      AC021092, BU633034, EG328378
      Consensus CDS
      CCDS46100.1
      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
      Conserved Domains (3) summary
      COG5048
      Location:202 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    2. NM_013362.4 → NP_037494.2  zinc finger protein 225

      See identical proteins and their annotated locations for NP_037494.2

      Status: VALIDATED

      Source sequence(s)
      AC021092, AK223477, BQ373092, BU633034, EG328378
      Consensus CDS
      CCDS46100.1
      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
      Related
      ENSP00000262894.5, ENST00000262894.11
      Conserved Domains (3) summary
      COG5048
      Location:202 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44111425..44134822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527286.3 → XP_011525588.1  zinc finger protein 225 isoform X1

      See identical proteins and their annotated locations for XP_011525588.1

      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
      Conserved Domains (3) summary
      COG5048
      Location:202 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    2. XM_011527285.3 → XP_011525587.1  zinc finger protein 225 isoform X1

      See identical proteins and their annotated locations for XP_011525587.1

      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
      Conserved Domains (3) summary
      COG5048
      Location:202 → 634
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:458 → 478
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    3. XM_005259223.4 → XP_005259280.1  zinc finger protein 225 isoform X2

      See identical proteins and their annotated locations for XP_005259280.1

      Conserved Domains (3) summary
      COG5048
      Location:119 → 551
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:135 → 160
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46934319..46957717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322028.1 → XP_054178003.1  zinc finger protein 225 isoform X1

      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10

    2. XM_054322027.1 → XP_054178002.1  zinc finger protein 225 isoform X1

      UniProtKB/Swiss-Prot
      A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10

    3. XM_054322029.1 → XP_054178004.1  zinc finger protein 225 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK10.2 GenPept UniProtKB/Swiss-Prot:Q9UK10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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