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    Hnrnpm heterogeneous nuclear ribonucleoprotein M [ Mus musculus (house mouse) ]

    Gene ID: 76936, updated on 12-May-2024

    Summary

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    Official Symbol
    Hnrnpmprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Mprovided by MGI
    Primary source
    MGI:MGI:1926465
    See related
    Ensembl:ENSMUSG00000059208 AllianceGenome:MGI:1926465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpm; mKIAA4193; 2610023M21Rik
    Summary
    Predicted to enable several functions, including calcium-dependent protein binding activity; mRNA binding activity; and protein antigen binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; positive regulation of protein localization; and regulation of mRNA stability involved in response to oxidative stress. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in collagen-containing extracellular matrix. Is expressed in several structures, including early conceptus; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 154.1), liver E14 (RPKM 82.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33865207..33904432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33646233..33685458, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene zinc finger protein 414 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity. Akinyemi AR, et al. Neurosci Lett, 2021 Apr 23. PMID 33727124
    2. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. West KO, et al. Cell Rep, 2019 Nov 5. PMID 31693898, Free PMC Article
    3. Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. Chen WY, et al. Sci Rep, 2017 Jan 20. PMID 28106162, Free PMC Article
    4. Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. Park E, et al. J Biol Chem, 2011 Jul 15. PMID 21622564, Free PMC Article
    5. Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development. Mahé D, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004512

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
      Title: hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
    2. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.
      Title: The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.
    3. Results have identified a novel Rictor associated protein, hnRNPM which was found to be able to affect the phosphorylation of SGK1 S422, a direct phosphorylation site of mTORC2. hnRNP M seem to mediate the SGK1 signaling that regulates muscle differentiation.
      Title: Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation.
    4. identify Nova-1 and hnRNP M as D2R pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R pre-mRNA.
      Title: Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein M
    Names
    hnRNP M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109913.1 → NP_001103383.1  heterogeneous nuclear ribonucleoprotein M isoform b

      See identical proteins and their annotated locations for NP_001103383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1, which results in shorter protein (isoform b) when compared to isoform a.
      Source sequence(s)
      AK220299, BC054785
      Consensus CDS
      CCDS50068.1
      UniProtKB/TrEMBL
      Q3THB3, Q3TW40
      Related
      ENSMUSP00000084864.6, ENSMUST00000087582.13
      Conserved Domains (5) summary
      COG0724
      Location:615 → 690
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:166 → 239
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:614 → 690
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:40 → 69
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:71 → 146
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_029804.3 → NP_084080.1  heterogeneous nuclear ribonucleoprotein M isoform a

      See identical proteins and their annotated locations for NP_084080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK220299, BC054785
      Consensus CDS
      CCDS37570.1
      UniProtKB/Swiss-Prot
      Q6P1B2, Q99JQ0, Q9D0E1
      UniProtKB/TrEMBL
      Q3TW40
      Related
      ENSMUSP00000120115.2, ENSMUST00000148178.8
      Conserved Domains (5) summary
      COG0724
      Location:654 → 729
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:205 → 278
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:71 → 146
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:653 → 729
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:40 → 69
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33865207..33904432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0E1.3 GenPept UniProtKB/Swiss-Prot:Q9D0E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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