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    Jade2 jade family PHD finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 76901, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Jade2provided by MGI
    Official Full Name
    jade family PHD finger 2provided by MGI
    Primary source
    MGI:MGI:1924151
    See related
    Ensembl:ENSMUSG00000020387 AllianceGenome:MGI:1924151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phf15; mKIAA0239; 1200017K05Rik
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within SMAD protein signal transduction; generation of neurons; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of histone acetyltransferase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 14.2), lung adult (RPKM 11.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 31.5 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51704278..51749835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51813448..51859011, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B Neighboring gene STARR-positive B cell enhancer ABC_E10673 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51671514-51671815 Neighboring gene predicted gene, 30110 Neighboring gene predicted gene, 39820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51697260-51697496 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51697614-51697723 Neighboring gene predicted gene, 39821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Tzouanacou E, et al. Mol Cell Biol, 2003 Dec. PMID 14612400, Free PMC Article
    2. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Han X, et al. Mol Cell, 2014 Aug 7. PMID 25018020
    3. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice. Fan M, et al. Biol Psychiatry, 2022 Nov 15. PMID 36008159
    4. USP10 deubiquitinates Tau, mediating its aggregation. Wei Z, et al. Cell Death Dis, 2022 Aug 20. PMID 35987808, Free PMC Article
    5. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.
      Title: JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.
    2. Results show that Jade-2 is a major LSD1 negative regulator during neurogenesis in vitro and in vivo in both mouse developing cerebral cortices and zebra fish embryos.
      Title: Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Jade-2
    Names
    PHD finger protein 15
    jade family PHD finger protein 2
    protein Jade-2
    NP_001344517.1
    NP_955003.2
    XP_006534531.1
    XP_006534532.1
    XP_006534533.1
    XP_011247611.1
    XP_036012980.1
    XP_036012981.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357588.3 → NP_001344517.1  E3 ubiquitin-protein ligase Jade-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645602, AL669920
      Conserved Domains (3) summary
      cd15705
      Location:326 → 436
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
      cl26464
      Location:676 → 852
      Atrophin-1; Atrophin-1 family
      cl26518
      Location:209 → 578
      EPL1; Enhancer of polycomb-like

    2. NM_199299.5 → NP_955003.2  E3 ubiquitin-protein ligase Jade-2 isoform 2

      See identical proteins and their annotated locations for NP_955003.2

      Status: VALIDATED

      Source sequence(s)
      AL645602, AL669920
      Consensus CDS
      CCDS24662.1
      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Related
      ENSMUSP00000020655.8, ENSMUST00000020655.14
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51704278..51749835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534470.5 → XP_006534533.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_006534533.1

      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    2. XM_011249309.3 → XP_011247611.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_011247611.1

      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    3. XM_036157088.1 → XP_036012981.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    4. XM_006534469.5 → XP_006534532.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      See identical proteins and their annotated locations for XP_006534532.1

      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    5. XM_006534468.5 → XP_006534531.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:640 → 816
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:173 → 542
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:290 → 400
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins

    6. XM_036157087.1 → XP_036012980.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UHD5, Q6IE83, Q6ZQF7
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 780
      PHA03247; large tegument protein UL36; Provisional
      COG5141
      Location:137 → 506
      COG5141; PHD zinc finger-containing protein [General function prediction only]
      cd15705
      Location:254 → 364
      ePHD_JADE2; Extended PHD finger found in protein Jade-2 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQF7.2 GenPept UniProtKB/Swiss-Prot:Q6ZQF7

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