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    Csta2 cystatin A family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 76770, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Csta2provided by MGI
    Official Full Name
    cystatin A family member 2provided by MGI
    Primary source
    MGI:MGI:1924020
    See related
    Ensembl:ENSMUSG00000095620 AllianceGenome:MGI:1924020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010005H15Rik
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular components, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver E18 (RPKM 59.3) See more
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    Genomic context

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    Location:
    16 B3; 16 25.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36041932..36077813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36221562..36257447)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10913 Neighboring gene cystatin A family member 3 Neighboring gene STARR-seq mESC enhancer starr_40762 Neighboring gene predicted gene, 24569 Neighboring gene stefin A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of peptidase inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Cystatin-A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384090.1 → NP_001371019.1  Cystatin-A-like

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT033776
      UniProtKB/TrEMBL
      Q9D8D6
      Related
      ENSMUSP00000067712.7, ENSMUST00000063539.7
      Conserved Domains (1) summary
      pfam00031
      Location:4 → 90
      Cystatin; Cystatin domain

    2. NM_029733.3 → NP_084009.1  Cystatin-A-like

      See identical proteins and their annotated locations for NP_084009.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC125422
      Consensus CDS
      CCDS37330.1
      UniProtKB/TrEMBL
      Q9D8D6
      Related
      ENSMUSP00000140745.2, ENSMUST00000187183.7
      Conserved Domains (1) summary
      pfam00031
      Location:4 → 90
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36041932..36077813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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