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    Tbkbp1 TBK1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 73174, updated on 8-May-2024

    Summary

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    Official Symbol
    Tbkbp1provided by MGI
    Official Full Name
    TBK1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1920424
    See related
    Ensembl:ENSMUSG00000038517 AllianceGenome:MGI:1920424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SINTBAD; ProSAPiP2; 3110043L15Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within innate immune response. Predicted to be active in cytoplasm. Is expressed in brown fat; genitourinary system; and nervous system. Orthologous to human TBKBP1 (TBK1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 13.5), limb E14.5 (RPKM 11.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 60.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97026997..97042332, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97136171..97151506, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 7 Neighboring gene microRNA 8103 Neighboring gene STARR-seq mESC enhancer starr_30581 Neighboring gene T-box 21 Neighboring gene STARR-positive B cell enhancer ABC_E8446 Neighboring gene STARR-positive B cell enhancer ABC_E8447 Neighboring gene microRNA 7235 Neighboring gene karyopherin subunit beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1842 Neighboring gene STARR-positive B cell enhancer ABC_E910 Neighboring gene aminopeptidase puromycin sensitive

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Zhu L, et al. Nat Commun, 2018 Jul 18. PMID 30022064, Free PMC Article
    2. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Zhu L, et al. Nat Cell Biol, 2019 Dec. PMID 31792381, Free PMC Article
    3. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. Soulat D, et al. EMBO J, 2008 Aug 6. PMID 18583960, Free PMC Article
    4. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. Ryzhakov G, et al. EMBO J, 2007 Jul 11. PMID 17568778, Free PMC Article
    5. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. Fukasaka M, et al. J Immunol, 2013 Jun 1. PMID 23610142

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SINTBAD regulates IL-15-induced autophagy and NKT cell survival.
      Title: TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
    2. results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades
      Title: SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TANK-binding kinase 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372527.1 → NP_001359456.1  TANK-binding kinase 1-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS48895.1
      UniProtKB/TrEMBL
      Z4YKN2
      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 332
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:289 → 341
      TBD; TBD domain

    2. NM_001372528.1 → NP_001359457.1  TANK-binding kinase 1-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS48895.1
      UniProtKB/TrEMBL
      Z4YKN2
      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 332
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:289 → 341
      TBD; TBD domain

    3. NM_001372529.1 → NP_001359458.1  TANK-binding kinase 1-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS88239.1
      UniProtKB/Swiss-Prot
      A2A9S9, A2A9T0, Q6PFF1
      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 341
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:290 → 342
      TBD; TBD domain

    4. NM_001372530.1 → NP_001359459.1  TANK-binding kinase 1-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS88239.1
      UniProtKB/Swiss-Prot
      A2A9S9, A2A9T0, Q6PFF1
      Related
      ENSMUSP00000103239.2, ENSMUST00000107614.8
      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 341
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:290 → 342
      TBD; TBD domain

    5. NM_001372531.1 → NP_001359460.1  TANK-binding kinase 1-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS88239.1
      UniProtKB/Swiss-Prot
      A2A9S9, A2A9T0, Q6PFF1
      Related
      ENSMUSP00000065461.6, ENSMUST00000066078.12
      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 341
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:290 → 342
      TBD; TBD domain

    6. NM_198100.3 → NP_932768.2  TANK-binding kinase 1-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627445
      Consensus CDS
      CCDS48895.1
      UniProtKB/TrEMBL
      Z4YKN2
      Related
      ENSMUSP00000112396.2, ENSMUST00000118375.8
      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 332
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:289 → 341
      TBD; TBD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97026997..97042332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534338.4 → XP_006534401.1  TANK-binding kinase 1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam12845
      Location:16 → 65
      TBD; TBD domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A9T0.1 GenPept UniProtKB/Swiss-Prot:A2A9T0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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