Mir30c-2 microRNA 30c-2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir30c-2provided by MGI
Official Full Name: microRNA 30c-2provided by MGI
Primary source: MGI:MGI:3619048
See related: Ensembl:ENSMUSG00000065567 miRBase:MI0000548; AllianceGenome:MGI:3619048
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn30c-2; mir-30c-2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 1 A5; 1 9.54 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (23330782..23330865)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (23291701..23291784)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer.
Title: The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer.
MicroRNA-30c-2-3p represses malignant progression of gastric adenocarcinoma cells via targeting ARHGAP11A.
Title: MicroRNA-30c-2-3p represses malignant progression of gastric adenocarcinoma cells via targeting ARHGAP11A.
miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
Title: miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via PPARalpha signaling pathway.
Title: MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα.
Overexpression of lncRNA AK017368 promoted proliferation and restrained differentiation of myoblasts, whereas inhibition of AK017368 had completely opposite effects in vitro. Knockdown of AK017368 promoted muscle hypertrophy in vivo. RNA molecules of AK017368 acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c.
Title: lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.
Study demonstrated increased levels of miR-30b and miR-30c in mouse serum after 5-9 Gy WBI, and this increase was radiation dose-dependent. Furthermore, putative miR-30 binding sites was found in the 3'UTR of Mcl-1 mRNA and showed that miR-30 directly inhibits the expression of Mcl-1 by binding to its target sequences.
Title: MicroRNA-30 inhibits antiapoptotic factor Mcl-1 in mouse and human hematopoietic cells after radiation exposure.
Identify miR-30c as a potential candidate for 5-HT2A receptor regulation to control serotonin-induced pulmonary artery constriction.
Title: MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction.
Our findings reveal a new role of miR-30c-5p in counterbalancing fatty acid biosynthesis, which is sufficient to attenuate triglyceride accumulation and hepatic steatosis in db/db mice
Title: MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN.
These results suggest a protective role of miR-30c against diabetic nephropathy by suppressing Epithelial-to-mesenchymal transition via inhibiting Snail1-TGF-beta1 pathway.
Title: MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice.
Data indicate the role for miRNA-30c in cardiac physiology, particularly in mitochondrial function.
Title: Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy.

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General gene information

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Markers

05.MMHAP59FLB2.seq (e-PCR)
- UniSTS:122822

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to forskolin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to inorganic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.