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    Sapcd2 suppressor APC domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 72080, updated on 8-May-2024

    Summary

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    Official Symbol
    Sapcd2provided by MGI
    Official Full Name
    suppressor APC domain containing 2provided by MGI
    Primary source
    MGI:MGI:1919330
    See related
    Ensembl:ENSMUSG00000026955 AllianceGenome:MGI:1919330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ang; 2010317E24Rik; 6030458L21Rik
    Summary
    Involved in establishment of mitotic spindle orientation; regulation of establishment of planar polarity; and symmetric cell division. Located in apical cortex. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and neural ectoderm. Orthologous to human SAPCD2 (suppressor APC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.1), limb E14.5 (RPKM 5.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 17.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25261974..25268225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25372035..25378213)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46732 Neighboring gene UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9505 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene neural proliferation, differentiation and control 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Murata T, et al. Gene Expr Patterns, 2004 Dec. PMID 15567712
    2. Ripply2 is essential for precise somite formation during mouse early development. Chan T, et al. FEBS Lett, 2007 Jun 12. PMID 17531978
    3. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Chiu CWN, et al. Dev Cell, 2016 Jan 11. PMID 26766442
    4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in symmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor APC domain-containing protein 2
    Names
    protein Ang
    protein C9orf140 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081085.2 → NP_001074554.1  suppressor APC domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK163973, AK166625, AL732557, CK331200
      Consensus CDS
      CCDS38073.1
      UniProtKB/Swiss-Prot
      Q9D818
      Related
      ENSMUSP00000028329.7, ENSMUST00000028329.13
      Conserved Domains (1) summary
      pfam11414
      Location:258 → 339
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

    2. NM_001290407.1 → NP_001277336.1  suppressor APC domain-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001277336.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK008577, AK166625, AL732557, CK331200
      Consensus CDS
      CCDS70999.1
      UniProtKB/Swiss-Prot
      A2AJ17, Q3TL89, Q3TP90, Q3TQ24, Q6NS42, Q9D818
      Related
      ENSMUSP00000109932.3, ENSMUST00000114293.9
      Conserved Domains (1) summary
      pfam11414
      Location:224 → 305
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25261974..25268225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498360.5 → XP_006498423.1  suppressor APC domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9D818
      Related
      ENSMUSP00000097898.3, ENSMUST00000100323.3
      Conserved Domains (1) summary
      pfam11414
      Location:224 → 305
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

    RNA

    1. XR_004940736.1 RNA Sequence

    2. XR_004940737.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D818.1 GenPept UniProtKB/Swiss-Prot:Q9D818

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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