U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Alpk1 alpha-kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 71481, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Alpk1provided by MGI
    Official Full Name
    alpha-kinase 1provided by MGI
    Primary source
    MGI:MGI:1918731
    See related
    Ensembl:ENSMUSG00000028028 AllianceGenome:MGI:1918731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAK; 8430410J10Rik
    Summary
    Predicted to enable monosaccharide binding activity and protein serine/threonine kinase activity. Involved in cytoplasmic pattern recognition receptor signaling pathway and innate immune response. Acts upstream of or within response to bacterium. Located in photoreceptor connecting cilium. Orthologous to human ALPK1 (alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 6.6), large intestine adult (RPKM 3.3) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    3 G2; 3 56.54 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127460367..127574195, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127666718..127780547, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40147 Neighboring gene neurogenin 2 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene STARR-positive B cell enhancer ABC_E6122 Neighboring gene adaptor-related protein complex 1 associated regulatory protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127540571-127540758 Neighboring gene predicted gene 43653

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway. Cui X, et al. Biol Res, 2023 Feb 2. PMID 36732854, Free PMC Article
    2. Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation. Li JY, et al. Int Immunopharmacol, 2022 Dec. PMID 36274483
    3. ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling. Liu X, et al. J Bone Miner Res, 2022 Oct. PMID 36053817
    4. Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome. Kozycki CT, et al. Ann Rheum Dis, 2022 Oct. PMID 35868845, Free PMC Article
    5. ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production. Kuo TM, et al. J Steroid Biochem Mol Biol, 2015 Nov. PMID 26275947

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
      Title: The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.
    2. Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
      Title: Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
    3. Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-kappaB pathway and neuroinflammation.
      Title: Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.
    4. ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
      Title: ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
    5. Gain-of-function mutations in ALPK1 cause an NF-kappaB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
      Title: Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
    6. Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-alpha Signaling Pathway.
      Title: Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway.
    7. findings identify ALPK1 and ADP-beta-D-manno-heptose as a pattern recognition receptor and an effective immunomodulator, respectively
      Title: Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
    8. Study demonstrates that Alpk1 promotes intestinal homoeostasis by regulating the balance of type 1/type 17 immunity following microbial challenge.
      Title: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
    9. data suggests that the balance between ALPK1 and testosterone plays a critical role in the testosterone-mediated inhibition of proinflammatory cytokines
      Title: ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-protein kinase 1
    Names
    lymphocyte alpha-kinase
    lymphocyte alpha-protein kinase
    NP_082084.1
    XP_006502164.1
    XP_006502165.1
    XP_006502166.1
    XP_006502167.1
    XP_006502171.1
    XP_036019220.1
    XP_036019221.1
    XP_036019222.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027808.1 → NP_082084.1  alpha-protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      AC158308, AC163391
      Consensus CDS
      CCDS51067.1
      UniProtKB/Swiss-Prot
      Q69ZH5, Q8BLT9, Q9CXB8
      UniProtKB/TrEMBL
      E9QNX4
      Related
      ENSMUSP00000029662.6, ENSMUST00000029662.12
      Conserved Domains (1) summary
      smart00811
      Location:1007 → 1215
      Alpha_kinase; Alpha-kinase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127460367..127574195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502102.4 → XP_006502165.1  alpha-protein kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q69ZH5, Q8BLT9, Q9CXB8
      Conserved Domains (1) summary
      cd16969
      Location:934 → 1160
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    2. XM_006502101.5 → XP_006502164.1  alpha-protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZH5, Q8BLT9, Q9CXB8
      Conserved Domains (1) summary
      cd16969
      Location:990 → 1216
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    3. XM_036163328.1 → XP_036019221.1  alpha-protein kinase 1 isoform X6

      Conserved Domains (1) summary
      cd16969
      Location:742 → 968
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    4. XM_006502103.3 → XP_006502166.1  alpha-protein kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q69ZH5, Q8BLT9, Q9CXB8
      Conserved Domains (1) summary
      cd16969
      Location:934 → 1160
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    5. XM_036163327.1 → XP_036019220.1  alpha-protein kinase 1 isoform X5

      Conserved Domains (1) summary
      cd16969
      Location:742 → 968
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    6. XM_006502108.3 → XP_006502171.1  alpha-protein kinase 1 isoform X5

      See identical proteins and their annotated locations for XP_006502171.1

      Conserved Domains (1) summary
      cd16969
      Location:742 → 968
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    7. XM_036163329.1 → XP_036019222.1  alpha-protein kinase 1 isoform X7

      Conserved Domains (1) summary
      cd16969
      Location:671 → 897
      Alpha_kinase_ALPK1; Alpha-kinase domain of alpha-protein kinase 1

    8. XM_006502104.4 → XP_006502167.1  alpha-protein kinase 1 isoform X4

      UniProtKB/Swiss-Prot
      Q69ZH5, Q8BLT9, Q9CXB8
      Conserved Domains (1) summary
      cl28917
      Location:990 → 1103
      Alpha_kinase; Alpha kinase family

    RNA

    1. XR_003954388.2 RNA Sequence

    2. XR_375582.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXB8.2 GenPept UniProtKB/Swiss-Prot:Q9CXB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous