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    Snap47 synaptosomal-associated protein, 47 [ Mus musculus (house mouse) ]

    Gene ID: 67826, updated on 7-May-2024

    Summary

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    Official Symbol
    Snap47provided by MGI
    Official Full Name
    synaptosomal-associated protein, 47provided by MGI
    Primary source
    MGI:MGI:1915076
    See related
    Ensembl:ENSMUSG00000009894 AllianceGenome:MGI:1915076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNAP-47; 1110031B06Rik
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within long-term synaptic potentiation. Located in several cellular components, including glutamatergic synapse; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human SNAP47 (synaptosome associated protein 47). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 109.4), cortex adult (RPKM 96.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 37.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59297967..59340868, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59407141..59450041, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 9A Neighboring gene predicted gene, 51865 Neighboring gene STARR-seq mESC enhancer starr_29623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:59198075-59198323 Neighboring gene serine protease 38 Neighboring gene predicted gene 15755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:59263537-59263646 Neighboring gene STARR-seq mESC enhancer starr_29624 Neighboring gene jumonji domain containing 4 Neighboring gene zinc finger protein 867 Neighboring gene ariadne homolog 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47. Urbina FL, et al. Cell Rep, 2021 Feb 9. PMID 33567284, Free PMC Article
    2. Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. Holt M, et al. J Biol Chem, 2006 Jun 23. PMID 16621800
    3. Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs. Corradini I, et al. Cereb Cortex, 2014 Feb. PMID 23064108
    4. LTP requires a unique postsynaptic SNARE fusion machinery. Jurado S, et al. Neuron, 2013 Feb 6. PMID 23395379, Free PMC Article
    5. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47.
      Title: TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47.
    2. SNAP-47 is a novel Qbc-SNARE with ubiquitous expression
      Title: Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptosomal-associated protein 47
    Names
    synaptosomal-associated 47 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356452.1 → NP_001343381.1  synaptosomal-associated protein 47 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoforn (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AI842642, AK049330, BY104758, CD363532
      Consensus CDS
      CCDS24767.1
      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    2. NM_001356454.1 → NP_001343383.1  synaptosomal-associated protein 47 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, leading to a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI842642, AK028053, BY104758
      UniProtKB/TrEMBL
      B2FDF6
      Conserved Domains (2) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain

    3. NM_144521.3 → NP_653104.1  synaptosomal-associated protein 47 isoform 1

      See identical proteins and their annotated locations for NP_653104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AI842642, AK028053, BY104758
      Consensus CDS
      CCDS24767.1
      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Related
      ENSMUSP00000010038.4, ENSMUST00000010038.10
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59297967..59340868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534022.5 → XP_006534085.1  synaptosomal-associated protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006534085.1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    2. XM_036156921.1 → XP_036012814.1  synaptosomal-associated protein 47 isoform X2

      UniProtKB/TrEMBL
      B2FDF6
      Conserved Domains (2) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain

    3. XM_036156920.1 → XP_036012813.1  synaptosomal-associated protein 47 isoform X2

      UniProtKB/TrEMBL
      B2FDF6
      Conserved Domains (2) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain

    4. XM_006534024.5 → XP_006534087.1  synaptosomal-associated protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006534087.1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    5. XM_006534023.2 → XP_006534086.1  synaptosomal-associated protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006534086.1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    6. XM_036156922.1 → XP_036012815.1  synaptosomal-associated protein 47 isoform X2

      UniProtKB/TrEMBL
      B2FDF6
      Conserved Domains (2) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain

    7. XM_030246254.2 → XP_030102114.1  synaptosomal-associated protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    8. XM_030246252.2 → XP_030102112.1  synaptosomal-associated protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    9. XM_030246251.2 → XP_030102111.1  synaptosomal-associated protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    10. XM_030246253.2 → XP_030102113.1  synaptosomal-associated protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif

    11. XM_036156919.1 → XP_036012812.1  synaptosomal-associated protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNK4, Q8BK87, Q8R570
      Conserved Domains (3) summary
      cd15888
      Location:106 → 170
      SNARE_SNAP47N; N-terminal SNARE motif of SNAP47
      cl17171
      Location:2 → 98
      PH-like; Pleckstrin homology-like domain
      cl22856
      Location:353 → 411
      SNARE; SNARE motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R570.1 GenPept UniProtKB/Swiss-Prot:Q8R570

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