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    Defa28 defensin, alpha, 28 [ Mus musculus (house mouse) ]

    Gene ID: 626682, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Defa28provided by MGI
    Official Full Name
    defensin, alpha, 28provided by MGI
    Primary source
    MGI:MGI:3646688
    See related
    Ensembl:ENSMUSG00000074434 AllianceGenome:MGI:3646688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm6696; EG626682
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of membrane permeability. Predicted to be located in intracellular membrane-bounded organelle and midbody. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA3 (defensin alpha 3) and DEFA6 (defensin alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 179.2), duodenum adult (RPKM 131.3) and 1 other tissue See more
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    Genomic context

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    Location:
    8 A2; 8 10.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22072976..22073883)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21582960..21583867)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24423 Neighboring gene defensin, alpha, 37 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene predicted gene, 24829 Neighboring gene defensin, alpha, 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pore-forming activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in disruption of plasma membrane integrity in another organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    defensin-6
    Names
    novel defensin-related cryptidin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177523.1 → NP_001170994.1  defensin-6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC133094
      Consensus CDS
      CCDS52511.1
      UniProtKB/TrEMBL
      D3Z1V9
      Related
      ENSMUSP00000096486.4, ENSMUST00000098887.4
      Conserved Domains (2) summary
      pfam00323
      Location:66 → 93
      Defensin_1; Mammalian defensin
      pfam00879
      Location:15 → 51
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22072976..22073883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312929.1 → XP_017168418.1  defensin-6 isoform X1

      UniProtKB/TrEMBL
      V9GZ96
      Conserved Domains (1) summary
      pfam00879
      Location:15 → 51
      Defensin_propep; Defensin propeptide
    Nucleotide Protein
    Heading Accession and Version

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