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    Uqcc6 ubiquinol-cytochrome c reductase complex assembly factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 544717, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Uqcc6provided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase complex assembly factor 6provided by MGI
    Primary source
    MGI:MGI:3698433
    See related
    Ensembl:ENSMUSG00000063320 AllianceGenome:MGI:3698433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brawnin; 1190007I07Rik
    Summary
    Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Orthologous to human C12orf73 (chromosome 12 open reading frame 73). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.0), duodenum adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82455685..82459062, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82619851..82623228, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27364 Neighboring gene required for meiotic nuclear division 5 homolog A pseudogene Neighboring gene adaptor-related protein complex 3, mu 1 subunit, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10632 Neighboring gene STARR-positive B cell enhancer ABC_E6890 Neighboring gene STARR-positive B cell enhancer ABC_E578 Neighboring gene STARR-seq mESC enhancer starr_27366 Neighboring gene thymine DNA glycosylase Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:82129373-82129482 Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8353 Neighboring gene STARR-seq mESC enhancer starr_27367 Neighboring gene STARR-seq mESC enhancer starr_27368 Neighboring gene host cell factor C2 Neighboring gene STARR-positive B cell enhancer ABC_E6891 Neighboring gene nuclear transcription factor-Y beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Liang C, et al. Cell Rep, 2022 Aug 16. PMID 35977508
    2. Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Zhang S, et al. Nat Commun, 2020 Mar 11. PMID 32161263, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol-cytochrome c reductase complex assembly factor 6
    Names
    protein BRAWNIN
    uncharacterized protein C12orf73 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135567.1 → NP_001129039.1  ubiquinol-cytochrome c reductase complex assembly factor 6

      See identical proteins and their annotated locations for NP_001129039.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC152980, AK004515
      Consensus CDS
      CCDS48653.1
      UniProtKB/Swiss-Prot
      Q8BTC1
      Related
      ENSMUSP00000078593.5, ENSMUST00000079648.12
      Conserved Domains (1) summary
      pfam14990
      Location:2 → 44
      DUF4516; Domain of unknown function (DUF4516)

    2. NM_001135568.1 → NP_001129040.1  ubiquinol-cytochrome c reductase complex assembly factor 6

      See identical proteins and their annotated locations for NP_001129040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC152980, DV649038
      Consensus CDS
      CCDS48653.1
      UniProtKB/Swiss-Prot
      Q8BTC1
      Related
      ENSMUSP00000139234.2, ENSMUST00000183363.2
      Conserved Domains (1) summary
      pfam14990
      Location:2 → 44
      DUF4516; Domain of unknown function (DUF4516)

    3. NM_001135569.1 → NP_001129041.1  ubiquinol-cytochrome c reductase complex assembly factor 6

      See identical proteins and their annotated locations for NP_001129041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 5' UTR, compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC152980
      Consensus CDS
      CCDS48653.1
      UniProtKB/Swiss-Prot
      Q8BTC1
      Related
      ENSMUSP00000139244.2, ENSMUST00000185168.8
      Conserved Domains (1) summary
      pfam14990
      Location:2 → 44
      DUF4516; Domain of unknown function (DUF4516)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      82455685..82459062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTC1.1 GenPept UniProtKB/Swiss-Prot:Q8BTC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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    Tools
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